KEGG   PATHWAY: ldc00983
Entry
ldc00983                    Pathway                                
Name
Drug metabolism - other enzymes - Leptinotarsa decemlineata (Colorado potato beetle)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
ldc00983  Drug metabolism - other enzymes
ldc00983

Organism
Leptinotarsa decemlineata (Colorado potato beetle) [GN:ldc]
Gene
111511552  inosine-5'-monophosphate dehydrogenase-like isoform X1 [KO:K00088] [EC:1.1.1.205]
111515635  LOW QUALITY PROTEIN: GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
111507449  LOW QUALITY PROTEIN: uncharacterized protein LOC111507449 [KO:K01951] [EC:6.3.5.2]
111502823  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
111514068  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
111508569  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
111509937  indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
111509938  indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
111505196  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
111505753  venom carboxylesterase-6-like [KO:K01044] [EC:3.1.1.1]
111510977  UDP-glucuronosyltransferase 1-10-like isoform X1 [KO:K00699] [EC:2.4.1.17]
111511174  UDP-glucuronosyltransferase 2B10-like [KO:K00699] [EC:2.4.1.17]
111512940  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
111513316  UDP-glucuronosyltransferase 2B30-like [KO:K00699] [EC:2.4.1.17]
111504789  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
111514251  UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
111515672  UDP-glucuronosyltransferase 2B2-like [KO:K00699] [EC:2.4.1.17]
111506694  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
111506695  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
111516487  UDP-glucuronosyltransferase 2B13-like [KO:K00699] [EC:2.4.1.17]
111516529  UDP-glucuronosyltransferase 2B9-like [KO:K00699] [EC:2.4.1.17]
111516574  putative UDP-glucuronosyltransferase ugt-47 [KO:K00699] [EC:2.4.1.17]
111506945  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
111506946  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
111507891  UDP-glucuronosyltransferase 2B20-like [KO:K00699] [EC:2.4.1.17]
111507895  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
111517685  UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
111517690  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
111508063  UDP-glucuronosyltransferase 2A3-like isoform X1 [KO:K00699] [EC:2.4.1.17]
111508065  UDP-glucuronosyltransferase 2B2-like [KO:K00699] [EC:2.4.1.17]
111508810  UDP-glucuronosyltransferase 1-3-like [KO:K00699] [EC:2.4.1.17]
111508948  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
111508953  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
111517418  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
111508839  dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
111517664  dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
111503463  beta-ureidopropionase-like [KO:K01431] [EC:3.5.1.6]
111503483  beta-ureidopropionase-like [KO:K01431] [EC:3.5.1.6]
111504745  beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
111512876  uridine phosphorylase 1 [KO:K00757] [EC:2.4.2.3]
111515593  LOW QUALITY PROTEIN: uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
111516624  probable uridine-cytidine kinase [KO:K00876] [EC:2.7.1.48]
111508596  probable uridine-cytidine kinase [KO:K00876] [EC:2.7.1.48]
111506125  uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
111507269  UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
111510796  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
111510799  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
111509986  ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
111512038  nucleoside diphosphate kinase 7-like [KO:K00940] [EC:2.7.4.6]
111503881  nucleoside diphosphate kinase 7-like [KO:K00940] [EC:2.7.4.6]
111504781  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
111509540  nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
111502916  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
111504311  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
111514056  glutathione S-transferase D1-like [KO:K00799] [EC:2.5.1.18]
111506313  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
111515104  uncharacterized protein LOC111515104 [KO:K00799] [EC:2.5.1.18]
111515116  uncharacterized protein LOC111515116 [KO:K00799] [EC:2.5.1.18]
111515122  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
111515176  glutathione S-transferase D7-like isoform X1 [KO:K00799] [EC:2.5.1.18]
111515202  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111515214  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111515223  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111515375  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111515376  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111515377  glutathione S-transferase D5-like [KO:K00799] [EC:2.5.1.18]
111506563  prostaglandin E synthase-like [KO:K00799] [EC:2.5.1.18]
111516160  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111507461  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
111517560  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
111508100  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111509100  microsomal glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
111509471  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111509532  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111509814  glutathione S-transferase D2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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