KEGG   PATHWAY: lper00053
Entry
lper00053                   Pathway                                
Name
Ascorbate and aldarate metabolism - Lolium perenne (perennial ryegrass)
Class
Metabolism; Carbohydrate metabolism
Pathway map
lper00053  Ascorbate and aldarate metabolism
lper00053

Module
lper_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:lper00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Lolium perenne (perennial ryegrass) [GN:lper]
Gene
127293869  UDP-glucose 6-dehydrogenase 2 [KO:K00012] [EC:1.1.1.22]
127294292  UDP-glucose 6-dehydrogenase 3-like [KO:K00012] [EC:1.1.1.22]
127292769  UDP-glucose 6-dehydrogenase 4 [KO:K00012] [EC:1.1.1.22]
127293147  UDP-glucose 6-dehydrogenase 4-like [KO:K00012] [EC:1.1.1.22]
127312522  UDP-sugar pyrophosphorylase [KO:K12447] [EC:2.7.7.64]
127324064  UDP-sugar pyrophosphorylase-like [KO:K12447] [EC:2.7.7.64]
127308678  probable glucuronokinase 2 [KO:K16190] [EC:2.7.1.43]
127313163  probable inositol oxygenase [KO:K00469] [EC:1.13.99.1]
127294820  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
127319396  aldose reductase [KO:K00002] [EC:1.1.1.2]
127322075  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
127322083  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
127322087  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
127322111  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
127322117  NADPH-dependent aldo-keto reductase, chloroplastic-like isoform X1 [KO:K00002] [EC:1.1.1.2]
127322148  NADPH-dependent aldo-keto reductase, chloroplastic-like isoform X1 [KO:K00002] [EC:1.1.1.2]
127344459  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
127344460  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
127344461  aldo-keto reductase family 4 member C10-like isoform X1 [KO:K00002] [EC:1.1.1.2]
127314284  probable L-gulonolactone oxidase 4 [KO:K00103] [EC:1.1.3.8]
127314292  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
127315916  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
127300857  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
127301158  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
127301160  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
127326120  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
127331152  L-gulonolactone oxidase 3 [KO:K00103] [EC:1.1.3.8]
127295215  GDP-mannose 3,5-epimerase 2 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
127319608  GDP-mannose 3,5-epimerase 2-like [KO:K10046] [EC:5.1.3.18 5.1.3.-]
127294111  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
127298659  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
127299618  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
127344999  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
127323229  inositol monophosphatase 3 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
127342405  bifunctional phosphatase IMPL2, chloroplastic [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
127300691  L-galactose dehydrogenase [KO:K17744] [EC:1.1.1.316]
127321787  L-galactono-1,4-lactone dehydrogenase 2, mitochondrial [KO:K00225] [EC:1.3.2.3]
127296417  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
127316657  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
127317905  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
127302272  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
127305602  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
127314797  monodehydroascorbate reductase 5, chlorplastic [KO:K08232] [EC:1.6.5.4]
127316089  monodehydroascorbate reductase 4, cytosolic [KO:K08232] [EC:1.6.5.4]
127303050  monodehydroascorbate reductase 3, cytosolic [KO:K08232] [EC:1.6.5.4]
127306490  monodehydroascorbate reductase 1, peroxisomal-like [KO:K08232] [EC:1.6.5.4]
127306491  monodehydroascorbate reductase 2, peroxisomal [KO:K08232] [EC:1.6.5.4]
127295873  L-ascorbate peroxidase 1, cytosolic [KO:K00434] [EC:1.11.1.11]
127316421  probable L-ascorbate peroxidase 4, peroxisomal [KO:K00434] [EC:1.11.1.11]
127299666  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
127331163  probable L-ascorbate peroxidase 3, peroxisomal isoform X1 [KO:K00434] [EC:1.11.1.11]
127331326  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
127334512  probable L-ascorbate peroxidase 8, chloroplastic [KO:K00434] [EC:1.11.1.11]
127334889  probable L-ascorbate peroxidase 7, chloroplastic [KO:K00434] [EC:1.11.1.11]
127317533  probable glutathione S-transferase DHAR2, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
127343142  probable glutathione S-transferase DHAR1, cytosolic isoform X1 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
127313233  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
127313234  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
127318719  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
127344826  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
127294803  aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
127335770  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
127317280  aldehyde dehydrogenase family 2 member B7, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
127299665  aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
127306282  benzaldehyde dehydrogenase, mitochondrial-like isoform X1 [KO:K00128] [EC:1.2.1.3]
127306899  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
127306903  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
127301419  aldehyde dehydrogenase family 7 member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
lper00020  Citrate cycle (TCA cycle)
lper00040  Pentose and glucuronate interconversions
lper00051  Fructose and mannose metabolism
lper00520  Amino sugar and nucleotide sugar metabolism
lper00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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