KEGG   PATHWAY: lsin00983
Entry
lsin00983                   Pathway                                
Name
Drug metabolism - other enzymes - Leptidea sinapis (Wood White)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
lsin00983  Drug metabolism - other enzymes
lsin00983

Organism
Leptidea sinapis (Wood White) [GN:lsin]
Gene
126970414  inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
126965232  GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
126964485  uncharacterized protein LOC126964485 isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
126964729  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
126974254  uncharacterized protein LOC126974254 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
126974257  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
126965358  xanthine dehydrogenase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
126965359  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
126980172  uncharacterized protein LOC126980172 isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
126979988  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
126972539  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
126973320  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126973390  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126973391  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126973408  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
126973565  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126973881  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
126974090  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126974091  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
126974092  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126974093  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126974094  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126975449  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
126975612  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126975618  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126966267  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126976366  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126976367  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126967447  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
126977393  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126977394  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
126967982  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
126967986  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126967988  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126968127  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
126977837  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126978685  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
126978692  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126978699  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126978705  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126978711  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126978725  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126978739  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126978749  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126978782  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126978791  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
126978799  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126978830  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
126978916  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
126979013  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
126979349  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126979350  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126975938  beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
126973789  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
126978606  dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
126970086  dihydropyrimidinase isoform X1 [KO:K01464] [EC:3.5.2.2]
126967442  beta-ureidopropionase-like [KO:K01431] [EC:3.5.1.6]
126968814  beta-ureidopropionase-like [KO:K01431] [EC:3.5.1.6]
126968819  uncharacterized protein LOC126968819 [KO:K01431] [EC:3.5.1.6]
126971633  uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
126967829  uridine phosphorylase 1-like isoform X1 [KO:K00757] [EC:2.4.2.3]
126964679  uridine-cytidine kinase isoform X1 [KO:K00876] [EC:2.7.1.48]
126965960  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
126969381  uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
126978016  UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
126971571  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
126976379  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
126965335  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
126965755  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
126976813  nucleoside diphosphate kinase 7-like [KO:K00940] [EC:2.7.4.6]
126976814  nucleoside diphosphate kinase 7-like isoform X1 [KO:K00940] [EC:2.7.4.6]
126976685  deoxyuridine 5'-triphosphate nucleotidohydrolase [KO:K01520] [EC:3.6.1.23]
126972193  glutathione S-transferase D7-like [KO:K00799] [EC:2.5.1.18]
126973146  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
126973274  pyrimidodiazepine synthase-like [KO:K00799] [EC:2.5.1.18]
126965808  glutathione S-transferase 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
126975471  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
126975472  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
126975473  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
126966751  glutathione S-transferase 1-1 [KO:K00799] [EC:2.5.1.18]
126976024  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
126979648  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
126971186  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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