KEGG   PATHWAY: maua00980
Entry
maua00980                   Pathway                                
Name
Metabolism of xenobiotics by cytochrome P450 - Mesocricetus auratus (golden hamster)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
maua00980  Metabolism of xenobiotics by cytochrome P450
maua00980

Organism
Mesocricetus auratus (golden hamster) [GN:maua]
Gene
101844540  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
101839568  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
101829268  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
101840543  glutathione S-transferase alpha-3-like [KO:K00799] [EC:2.5.1.18]
101843100  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
101843394  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
101843674  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
101843938  glutathione S-transferase theta-3 [KO:K00799] [EC:2.5.1.18]
101838578  Mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
101822455  glutathione S-transferase A6 [KO:K00799] [EC:2.5.1.18]
101840807  glutathione S-transferase A3 [KO:K00799] [EC:2.5.1.18]
110341285  glutathione S-transferase alpha-3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
101843868  glutathione S-transferase alpha-4 [KO:K00799] [EC:2.5.1.18]
101827423  Gstm3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
101827684  glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
110339199  glutathione S-transferase Mu 7 [KO:K00799] [EC:2.5.1.18]
101828115  glutathione S-transferase Mu 6 isoform X2 [KO:K00799] [EC:2.5.1.18]
101829715  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
101830172  Gstm4; glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
101827603  Mgst2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
110342127  LOW QUALITY PROTEIN: glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
110341553  glutathione S-transferase A2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
106021440  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
110341562  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
101842834  Gsto2; glutathione S-transferase omega-2 isoform X1 [KO:K00799] [EC:2.5.1.18]
101827709  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
101830434  Mgst1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
101841030  Gstp1; glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
101840758  glutathione S-transferase P 2-like isoform X2 [KO:K23790] [EC:2.5.1.18]
101833355  Gstk1; glutathione S-transferase kappa 1 [KO:K13299] [EC:2.5.1.18]
101832464  Hpgds; hematopoietic prostaglandin D synthase isoform X1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
101835523  epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
121137159  epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
101826585  alcohol sulfotransferase A-like [KO:K11822] [EC:2.8.2.14]
121132754  sulfotransferase 2A1-like [KO:K11822] [EC:2.8.2.14]
101841850  sulfotransferase 2A1-like [KO:K11822] [EC:2.8.2.14]
101831195  sulfotransferase 2A1 [KO:K11822] [EC:2.8.2.14]
101825565  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
101843716  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
101825629  cytochrome P450 2F2 [KO:K07416] [EC:1.14.14.1]
101828339  cytochrome P450 2S1 isoform X1 [KO:K07420] [EC:1.14.14.1]
101839651  aldo-keto reductase family 1 member C21 [KO:K00212] [EC:1.1.1.149 1.1.1.357 1.3.1.20]
101843587  aldo-keto reductase family 1 member C21 [KO:K00212] [EC:1.1.1.149 1.1.1.357 1.3.1.20]
101825360  Dhdh; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase [KO:K00078] [EC:1.3.1.20 1.1.1.179]
101835279  Hsd11b1; corticosteroid 11-beta-dehydrogenase isozyme 1 [KO:K15680] [EC:1.1.1.146]
121141872  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
121141873  carbonyl reductase [NADPH] 1-like isoform X1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
121141874  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
121141594  carbonyl reductase [NADPH] 2 isoform X1 [KO:K00081] [EC:1.1.1.184]
110340860  carbonyl reductase [NADPH] 2 [KO:K00081] [EC:1.1.1.184]
121141595  carbonyl reductase [NADPH] 2-like [KO:K00081] [EC:1.1.1.184]
106021442  Cbr3; carbonyl reductase [NADPH] 3 [KO:K00084] [EC:1.1.1.184]
101842501  UDP-glucuronosyltransferase 2A3 [KO:K00699] [EC:2.4.1.17]
101843034  UDP-glucuronosyltransferase 2B7-like isoform X1 [KO:K00699] [EC:2.4.1.17]
101843667  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
101843930  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
101844450  UDP-glucuronosyltransferase 2B1 isoform X1 [KO:K00699] [EC:2.4.1.17]
101822554  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
101842056  UDP-glucuronosyltransferase 2A2 isoform X2 [KO:K00699] [EC:2.4.1.17]
101841486  UDP-glucuronosyltransferase 1A1 isoform X2 [KO:K00699] [EC:2.4.1.17]
121142750  UDP-glucuronosyltransferase 1A5-like [KO:K00699] [EC:2.4.1.17]
121142751  UDP-glucuronosyltransferase 1A3-like [KO:K00699] [EC:2.4.1.17]
121142752  UDP-glucuronosyltransferase 1A7-like [KO:K00699] [EC:2.4.1.17]
101844897  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
121140860  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
121140861  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
101822914  UDP-glucuronosyltransferase 2B17-like isoform X1 [KO:K00699] [EC:2.4.1.17]
121140865  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
101843125  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
110340534  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
121140982  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
101835797  aflatoxin B1 aldehyde reductase member 2 isoform X1 [KO:K15303]
101836059  aflatoxin B1 aldehyde reductase member 3 [KO:K15303]
101832760  aldehyde dehydrogenase family 3 member B2 isoform X1 [KO:K00129] [EC:1.2.1.5]
101837223  Aldh3a1; aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00129] [EC:1.2.1.5]
101842109  Aldh3b1; aldehyde dehydrogenase family 3 member B1 isoform X1 [KO:K00129] [EC:1.2.1.5]
101822784  alcohol dehydrogenase 1 [KO:K13951] [EC:1.1.1.1]
121142314  alcohol dehydrogenase 1-like [KO:K13951] [EC:1.1.1.1]
101823051  alcohol dehydrogenase 1 [KO:K13951] [EC:1.1.1.1]
121142315  alcohol dehydrogenase 1-like isoform X1 [KO:K13951] [EC:1.1.1.1]
121142316  Adh7; all-trans-retinol dehydrogenase [NAD(+)] ADH7 isoform X1 [KO:K13951] [EC:1.1.1.1]
101836391  all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
101844855  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
101822511  alcohol dehydrogenase 6 isoform X1 [KO:K13952] [EC:1.1.1.1]
Compound
C00745  Nicotine
C00829  Naphthalene
C02617  1,4-Naphthoquinone
C03012  Naphthalene-1,2-diol
C06205  1,2-Dihydronaphthalene-1,2-diol
C06755  Chloroacetic acid
C06790  Trichloroethene
C06800  Aflatoxin B1
C06899  Chloral hydrate
C07490  Trichloroethanol
C07535  Benzo[a]pyrene
C11036  Bromobenzene
C11088  1,2-Dibromoethane
C11148  TCE epoxide
C11149  Dichloroacetate
C11150  Trichloroacetate
C11278  Aflatoxin B1exo-8,9-epoxide-GSH
C11713  2-Naphthol
C11714  1-Naphthol
C14039  1,1-Dichloroethylene
C14040  1-Nitronaphthalene
C14453  4-Bromophenol
C14556  9-Hydroxybenzo[a]pyrene
C14783  1,2-Naphthoquinone
C14784  1,2-Dihydroxy-3,4-epoxy-1,2,3,4-tetrahydronaphthalene
C14785  1,4-Dihydroxynaphthalene
C14786  (1R,2S)-Naphthalene 1,2-oxide
C14787  (1S,2R)-Naphthalene 1,2-oxide
C14788  1-Nitrosonaphthalene
C14789  N-Hydroxy-1-aminonaphthalene
C14790  1-Naphthylamine
C14791  (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
C14792  (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
C14793  (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
C14796  (1R)-Hydroxy-(2R)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
C14797  (1R)-N-Acetyl-L-cysteinyl-(2R)-hydroxy-1,2-dihydronaphthalene
C14798  (1S)-Hydroxy-(2S)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
C14799  (1R,2R)-3-[(1,2-Dihydro-2-hydroxy-1-naphthalenyl)thio]-2-oxopropanoic acid
C14800  1-Nitronaphthalene-5,6-oxide
C14801  1-Nitro-5,6-dihydroxy-dihydronaphthalene
C14802  1-Nitronaphthalene-7,8-oxide
C14803  1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene
C14804  1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene
C14805  1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene
C14806  1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene
C14839  Bromobenzene-3,4-oxide
C14840  Bromobenzene-2,3-oxide
C14841  2-Bromophenol
C14842  Bromobenzene-2,3-dihydrodiol
C14843  4-Bromocatechol
C14844  Bromobenzene-3,4-dihydrodiol
C14845  4-Bromophenol-2,3-epoxide
C14846  4-Bromo-3,5-cyclohexadiene-1,2-dione
C14847  3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene
C14848  2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene
C14849  Benzo[a]pyrene-9,10-oxide
C14850  Benzo[a]pyrene-7,8-oxide
C14851  Benzo[a]pyrene-4,5-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C14853  Benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide
C14854  9-Hydroxybenzo[a]pyrene-4,5-oxide
C14855  4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene
C14856  7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene
C14857  1,1-Dichloroethylene epoxide
C14858  2,2-Dichloroacetaldehyde
C14859  Chloroacetyl chloride
C14860  2,2-Dichloro-1,1-ethanediol
C14861  S-(2,2-Dichloro-1-hydroxy)ethyl glutathione
C14862  2-S-Glutathionyl acetate
C14863  2-(S-Glutathionyl)acetyl glutathione
C14864  S-(2-Chloroacetyl)glutathione
C14865  2-(S-Glutathionyl)acetyl chloride
C14866  Chloral
C14867  Dichloroacetyl chloride
C14868  S-(1,2-Dichlorovinyl)glutathione
C14869  Trichloroethanol glucuronide
C14870  2-Bromoacetaldehyde
C14871  S-(Formylmethyl)glutathione
C14872  Thiodiacetic acid
C14873  Thiodiacetic acid sulfoxide
C14874  Glutathione episulfonium ion
C14875  S-(2-Hydroxyethyl)glutathione
C14876  S-(2-Hydroxyethyl)-N-acetyl-L-cysteine
C14877  S-[2-(N7-Guanyl)ethyl]-N-acetyl-L-cysteine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16756  Aflatoxin M1
C19488  7,12-Dimethylbenz[a]anthracene
C19489  1a,11b-Dihydro-4,9-dimethylbenz[a]anthra[3,4-b]oxirene
C19490  trans-3,4-Dihydro-3,4-dihydroxy-7,12-dimethylbenz[a]anthracene
C19559  (1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-Tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol
C19561  7-Hydroxymethyl-12-methylbenz[a]anthracene
C19562  7-Hydroxymethyl-12-methylbenz[a]anthracene sulfate
C19563  4-[(Hydroxymethyl)nitrosoamino]-1-(3-pyridinyl)-1-butanone
C19564  4-(Nitrosoamino)-1-(3-pyridinyl)-1-butanone
C19565  4-Hydroxy-1-(3-pyridinyl)-1-butanone
C19566  4-Hydroxy-4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone
C19567  4-Oxo-1-(3-pyridyl)-1-butanone
C19568  N-Nitrosomethanamine
C19569  3-Succinoylpyridine
C19574  4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
C19577  1-(Methylnitrosoamino)-4-(3-pyridinyl)-1,4-butanediol
C19578  5-(3-Pyridyl)-2-hydroxytetrahydrofuran
C19579  gamma-Hydroxy-3-pyridinebutanoate
C19580  alpha-[3-[(Hydroxymethyl)nitrosoamino]propyl]-3-pyridinemethanol
C19581  alpha-[3-(Nitrosoamino)propyl]-3-pyridinemethanol
C19582  1-(3-Pyridinyl)-1,4-butanediol
C19585  Aflatoxin Q1
C19586  Aflatoxin B1-exo-8,9-epoxide
C19588  Aflatoxin B1 diol
C19589  Aflatoxin B1 dialdehyde
C19590  6-[2,3-Dihydroxy-1-(hydroxymethyl)propyl]-1,2-dihydro-7-hydroxy-9-methoxy-cyclopenta[c][1]benzopyran-3,4-dione
C19591  1,2,3,4-Tetrahydro-alpha,7-dihydroxy-beta-(hydroxymethyl)-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-propanal
C19592  alpha-(1,2-Dihydroxyethyl)-1,2,3,4-tetrahydro-7-hydroxy-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-acetaldehyde
C19594  Aflatoxin-M1-8,9-epoxide
C19595  Aflatoxin B1-endo-8,9-epoxide
C19602  4-(Methylnitrosamino)-1-(1-oxido-3-pyridinyl)-1-butanone
C19603  4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol
C19604  7,12-Dimethylbenz[a]anthracene 5,6-oxide
C19605  4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronide
C19606  NNAL-N-glucuronide
C19607  trans-5,6-Dihydro-5,6-dihydroxy-7,12-dimethylbenz[a]anthracene
Reference
  Authors
Buckpitt A, Boland B, Isbell M, Morin D, Shultz M, Baldwin R, Chan K, Karlsson A, Lin C, Taff A, West J, Fanucchi M, Van Winkle L, Plopper C.
  Title
Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity.
  Journal
Drug Metab Rev 34:791-820 (2002)
DOI:10.1081/DMR-120015694
Reference
  Authors
Bolton JL, Trush MA, Penning TM, Dryhurst G, Monks TJ.
  Title
Role of quinones in toxicology.
  Journal
Chem Res Toxicol 13:135-60 (2000)
DOI:10.1021/tx9902082
Reference
  Authors
Halladay JS, Sauer JM, Sipes IG.
  Title
Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats.
  Journal
Drug Metab Dispos 27:1456-65 (1999)
Reference
  Authors
Watt KC, Morin DM, Kurth MJ, Mercer RS, Plopper CG, Buckpitt AR.
  Title
Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy.
  Journal
Chem Res Toxicol 12:831-9 (1999)
DOI:10.1021/tx990023v
Reference
  Authors
Simmonds AC, Reilly CA, Baldwin RM, Ghanayem BI, Lanza DL, Yost GS, Collins KS, Forkert PG.
  Title
Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes.
  Journal
Drug Metab Dispos 32:1032-9 (2004)
Reference
  Authors
Forkert PG, Baldwin RM, Millen B, Lash LH, Putt DA, Shultz MA, Collins KS.
  Title
Pulmonary bioactivation of trichloroethylene to chloral hydrate: relative contributions of CYP2E1, CYP2F, and CYP2B1.
  Journal
Drug Metab Dispos 33:1429-37 (2005)
DOI:10.1124/dmd.105.005074
Reference
PMID:9107551
  Authors
Wormhoudt LW, Commandeur JN, Ploemen JH, Abdoelgafoer RS, Makansi A, Van Bladeren PJ, Vermeulen NP.
  Title
Urinary thiodiacetic acid. A selective biomarker for the cytochrome P450-catalyzed oxidation of 1,2-dibromoethane in the rat.
  Journal
Drug Metab Dispos 25:508-15 (1997)
Reference
PMID:4395686
  Authors
Brodie BB, Reid WD, Cho AK, Sipes G, Krishna G, Gillette JR.
  Title
Possible mechanism of liver necrosis caused by aromatic organic compounds.
  Journal
Proc Natl Acad Sci U S A 68:160-4 (1971)
DOI:10.1073/pnas.68.1.160
Reference
  Authors
Lodovici M, Luceri C, Guglielmi F, Bacci C, Akpan V, Fonnesu ML, Boddi V, Dolara P.
  Title
Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH.
  Journal
Cancer Epidemiol Biomarkers Prev 13:1342-8 (2004)
Reference
  Authors
Omura T, Ishimura Y, Fujii Y (eds).
  Title
[Molecular Biology of P450] (In Japanese)
  Journal
Kodansya (2003)
KO pathway
ko00980   
LinkDB

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