KEGG   PATHWAY: maua00982
Entry
maua00982                   Pathway                                
Name
Drug metabolism - cytochrome P450 - Mesocricetus auratus (golden hamster)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
maua00982  Drug metabolism - cytochrome P450
maua00982

Organism
Mesocricetus auratus (golden hamster) [GN:maua]
Gene
101824162  Fmo4; dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
101824685  Fmo2; dimethylaniline monooxygenase [N-oxide-forming] 2 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
101824953  putative dimethylaniline monooxygenase [N-oxide-forming] 6 isoform X1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
101836443  flavin-containing monooxygenase 5-like [KO:K00485] [EC:1.14.13.8 1.8.1.-]
101833243  dimethylaniline monooxygenase [N-oxide-forming] 3 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
101836707  flavin-containing monooxygenase 5-like [KO:K00485] [EC:1.14.13.8 1.8.1.-]
101824426  Fmo1; dimethylaniline monooxygenase [N-oxide-forming] 1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
101835746  Fmo5; flavin-containing monooxygenase 5 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
101829268  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
101840543  glutathione S-transferase alpha-3-like [KO:K00799] [EC:2.5.1.18]
101843100  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
101843394  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
101843674  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
101843938  glutathione S-transferase theta-3 [KO:K00799] [EC:2.5.1.18]
101838578  Mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
101822455  glutathione S-transferase A6 [KO:K00799] [EC:2.5.1.18]
101840807  glutathione S-transferase A3 [KO:K00799] [EC:2.5.1.18]
110341285  glutathione S-transferase alpha-3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
101843868  glutathione S-transferase alpha-4 [KO:K00799] [EC:2.5.1.18]
101827423  Gstm3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
101827684  glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
110339199  glutathione S-transferase Mu 7 [KO:K00799] [EC:2.5.1.18]
101828115  glutathione S-transferase Mu 6 isoform X2 [KO:K00799] [EC:2.5.1.18]
101829715  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
101830172  Gstm4; glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
101827603  Mgst2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
110342127  LOW QUALITY PROTEIN: glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
110341553  glutathione S-transferase A2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
106021440  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
110341562  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
101842834  Gsto2; glutathione S-transferase omega-2 isoform X1 [KO:K00799] [EC:2.5.1.18]
101827709  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
101830434  Mgst1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
101841030  Gstp1; glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
101840758  glutathione S-transferase P 2-like isoform X2 [KO:K23790] [EC:2.5.1.18]
101833355  Gstk1; glutathione S-transferase kappa 1 [KO:K13299] [EC:2.5.1.18]
101832464  Hpgds; hematopoietic prostaglandin D synthase isoform X1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
101822784  alcohol dehydrogenase 1 [KO:K13951] [EC:1.1.1.1]
121142314  alcohol dehydrogenase 1-like [KO:K13951] [EC:1.1.1.1]
101823051  alcohol dehydrogenase 1 [KO:K13951] [EC:1.1.1.1]
121142315  alcohol dehydrogenase 1-like isoform X1 [KO:K13951] [EC:1.1.1.1]
121142316  Adh7; all-trans-retinol dehydrogenase [NAD(+)] ADH7 isoform X1 [KO:K13951] [EC:1.1.1.1]
101836391  all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
101844855  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
101822511  alcohol dehydrogenase 6 isoform X1 [KO:K13952] [EC:1.1.1.1]
101832760  aldehyde dehydrogenase family 3 member B2 isoform X1 [KO:K00129] [EC:1.2.1.5]
101837223  Aldh3a1; aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00129] [EC:1.2.1.5]
101842109  Aldh3b1; aldehyde dehydrogenase family 3 member B1 isoform X1 [KO:K00129] [EC:1.2.1.5]
101825598  Maob; amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
101825859  Maoa; amine oxidase [flavin-containing] A isoform X1 [KO:K00274] [EC:1.4.3.4]
101823275  aldehyde oxidase 2 isoform X1 [KO:K00157] [EC:1.2.3.1]
101823544  aldehyde oxidase 4 [KO:K00157] [EC:1.2.3.1]
101823809  aldehyde oxidase 3 isoform X1 [KO:K00157] [EC:1.2.3.1]
101842897  aldehyde oxidase 1 isoform X1 [KO:K00157] [EC:1.2.3.1]
101842501  UDP-glucuronosyltransferase 2A3 [KO:K00699] [EC:2.4.1.17]
101843034  UDP-glucuronosyltransferase 2B7-like isoform X1 [KO:K00699] [EC:2.4.1.17]
101843667  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
101843930  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
101844450  UDP-glucuronosyltransferase 2B1 isoform X1 [KO:K00699] [EC:2.4.1.17]
101822554  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
101842056  UDP-glucuronosyltransferase 2A2 isoform X2 [KO:K00699] [EC:2.4.1.17]
101841486  UDP-glucuronosyltransferase 1A1 isoform X2 [KO:K00699] [EC:2.4.1.17]
121142750  UDP-glucuronosyltransferase 1A5-like [KO:K00699] [EC:2.4.1.17]
121142751  UDP-glucuronosyltransferase 1A3-like [KO:K00699] [EC:2.4.1.17]
121142752  UDP-glucuronosyltransferase 1A7-like [KO:K00699] [EC:2.4.1.17]
101844897  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
121140860  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
121140861  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
101822914  UDP-glucuronosyltransferase 2B17-like isoform X1 [KO:K00699] [EC:2.4.1.17]
121140865  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
101843125  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
110340534  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
121140982  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
101825565  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
101843716  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
Compound
C01471  Acrolein
C01516  Morphine
C05011  Hydroxytamoxifen
C06174  Codeine
C06754  Chloroacetaldehyde
C06868  Carbamazepine
C07047  Ifosfamide
C07073  Lidocaine
C07108  Tamoxifen
C07163  Methadone
C07185  Valproic acid
C07492  Oxcarbazepine
C07493  10-Hydroxycarbazepine
C07495  Dihydroxycarbazepine
C07496  Carbamazepine-10,11-epoxide
C07501  Felbamate
C07572  Citalopram
C07643  4-Hydroxycyclophosphamide
C07644  4-Ketocyclophosphamide
C07645  Aldophosphamide
C07646  Carboxyphosphamide
C07647  Phosphoramide mustard
C07888  Cyclophosphamide
C08012  Levomethadyl acetate
C11004  2,6-Dimethylaniline
C11583  4-Glutathionyl cyclophosphamide
C11785  Normorphine
C16544  alpha-Hydroxytamoxifen
C16545  Tamoxifen N-oxide
C16546  N-Desmethyltamoxifen
C16547  Endoxifen
C16548  N,N-Didesmethyltamoxifen
C16549  alpha-Hydroxy-N-desmethyltamoxifen
C16550  Dechloroethylcyclophosphamide
C16551  Alcophosphamide
C16552  Nornitrogen mustard
C16553  4-Hydroxyifosfamide
C16554  4-Ketoifosfamide
C16555  2-Dechloroethylifosfamide
C16556  Aldoifosfamide
C16557  Carboxyifosfamide
C16558  Alcoifosfamide
C16559  Isophosphoramide mustard
C16560  3-Hydroxylidocaine
C16561  Monoethylglycinexylidide
C16569  Glycinexylidide
C16570  4-Hydroxy-2,6-dimethylaniline
C16571  2-Amino-3-methylbenzoate
C16572  3-Hydroxymonoethylglycinexylidide
C16576  Norcodeine
C16577  Codeine-6-glucuronide
C16578  Morphine-6-glucuronide
C16582  2-Hydroxyfelbamate
C16584  p-Hydroxyfelbamate
C16586  2-Phenyl-1,3-propanediol monocarbamate
C16587  3-Carbamoyl-2-phenylpropionaldehyde
C16591  3-Carbamoyl-2-phenylpropionic acid
C16592  Atropaldehyde
C16595  4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one
C16596  5-Phenyl-1,3-oxazinane-2,4-dione
C16601  2-Hydroxycarbamazepine
C16602  3-Hydroxycarbamazepine
C16603  2,3-Dihydroxycarbamazepine
C16604  2-Hydroxyiminostilbene
C16605  2H-Dibenz[b,f]azepin-2-one
C16606  Carbamazepine-o-quinone
C16607  Citalopram N-oxide
C16608  Demethylcitalopram
C16609  Didemethylcitalopram
C16610  Citalopram propionic acid
C16612  Citalopram aldehyde
C16643  Morphine-3-glucuronide
C16648  2-n-Propyl-4-pentenoic acid
C16649  4-Hydroxyvalproic acid
C16650  5-Hydroxyvalproic acid
C16651  3-Hydroxyvalproic acid
C16652  3-Oxovalproic acid
C16653  2-n-Propyl-2-pentenoic acid
C16654  2-n-Propyl-3-pentenoic acid
C16655  2-n-Propyl-4-oxopentanoic acid
C16656  2-Propyl-2,4-pentadienoic acid
C16657  2-Propylsuccinic acid
C16658  2-Propylglutaric acid
C16659  2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
C16660  2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
C16661  L-alpha-Acetyl-N-normethadol
C16662  L-alpha-Acetyl-N,N-dinormethadol
D00195  Codeine (USP)
D00252  Carbamazepine (JP18/USP/INN)
D00343  Ifosfamide (JAN/USP/INN)
D00358  Lidocaine (JP18/USP/INN)
D00399  Valproic acid (USP)
D00533  Oxcarbazepine (JAN/USP/INN)
D00536  Felbamate (USPINN)
D04716  Levomethadyl acetate (USAN)
D07704  Citalopram (USP/INN)
D07760  Cyclophosphamide (INN)
D08195  Methadone (BAN)
D08233  Morphine (BAN)
D08559  Tamoxifen (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Gjerde J, Kisanga ER, Hauglid M, Holm PI, Mellgren G, Lien EA.
  Title
Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry.
  Journal
J Chromatogr A 1082:6-14 (2005)
DOI:10.1016/j.chroma.2005.01.004
Reference
  Authors
Buck MB, Coller JK, Murdter TE, Eichelbaum M, Knabbe C.
  Title
TGFbeta2 and TbetaRII are valid molecular biomarkers for the antiproliferative effects of tamoxifen and tamoxifen metabolites in breast cancer cells.
  Journal
Breast Cancer Res Treat 107:15-24 (2008)
DOI:10.1007/s10549-007-9526-7
Reference
  Authors
Rodriguez-Antona C, Ingelman-Sundberg M.
  Title
Cytochrome P450 pharmacogenetics and cancer.
  Journal
Oncogene 25:1679-91 (2006)
DOI:10.1038/sj.onc.1209377
Reference
  Authors
Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, Duan W, Zhu YZ.
  Title
Metabolism and transport of oxazaphosphorines and the clinical implications.
  Journal
Drug Metab Rev 37:611-703 (2005)
DOI:10.1080/03602530500364023
Reference
  Authors
Kosel M, Amey M, Aubert AC, Baumann P.
  Title
In vitro metabolism of citalopram by monoamine oxidase B in human blood.
  Journal
Eur Neuropsychopharmacol 11:75-8 (2001)
DOI:10.1016/S0924-977X(00)00128-0
Reference
  Authors
Olesen OV, Linnet K.
  Title
Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes.
  Journal
Pharmacology 59:298-309 (1999)
DOI:10.1159/000028333
Reference
PMID:9698084
  Authors
Rochat B, Kosel M, Boss G, Testa B, Gillet M, Baumann P.
  Title
Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver.
  Journal
Biochem Pharmacol 56:15-23 (1998)
DOI:10.1016/S0006-2952(98)00008-2
Reference
  Authors
David AW, Thomas LL, William OF.
  Title
Foye's Principles of Medicinal Chemistry (5th ed)
  Journal
Lippincott Williams & Wilkins (2002)
Reference
  Authors
Oda Y, Kharasch ED.
  Title
Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.
  Journal
J Pharmacol Exp Ther 298:1021-32 (2001)
Reference
  Authors
Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT.
  Title
Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.
  Journal
Drug Metab Dispos 28:959-65 (2000)
Reference
  Authors
Dieckhaus CM, Thompson CD, Roller SG, Macdonald TL.
  Title
Mechanisms of idiosyncratic drug reactions: the case of felbamate.
  Journal
Chem Biol Interact 142:99-117 (2002)
DOI:10.1016/S0009-2797(02)00057-1
Reference
  Authors
Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS
  Title
Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
  Journal
Drug Metab Dispos 36:1637-49 (2008)
DOI:10.1124/dmd.107.019562
Reference
  Authors
Pearce RE, Vakkalagadda GR, Leeder JS.
  Title
Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
  Journal
Drug Metab Dispos 30:1170-9 (2002)
DOI:10.1124/dmd.30.11.1170
Reference
  Authors
Kumar S, Wong H, Yeung SA, Riggs KW, Abbott FS, Rurak DW.
  Title
Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.
  Journal
Drug Metab Dispos 28:857-64 (2000)
Reference
  Authors
Bernad T, Joachim M.
  Title
Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology
  Journal
Wiley-VCH (2003)
KO pathway
ko00982   
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