KEGG   PATHWAY: mbx00630
Entry
mbx00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Mycobacterium tuberculosis variant bovis BCG ATCC 35743
Class
Metabolism; Carbohydrate metabolism
Pathway map
mbx00630  Glyoxylate and dicarboxylate metabolism
mbx00630

Module
mbx_M00012  Glyoxylate cycle [PATH:mbx00630]
mbx_M00621  Glycine cleavage system [PATH:mbx00630]
mbx_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:mbx00630]
Other DBs
GO: 0046487 0043648
Organism
Mycobacterium tuberculosis variant bovis BCG ATCC 35743 [GN:mbx]
Gene
BCGT_0241  Isocitrate lyase / Methylisocitrate lyase [KO:K01637] [EC:4.1.3.1 4.1.3.30]
BCGT_1746  Isocitrate lyase [KO:K01637] [EC:4.1.3.1 4.1.3.30]
BCGT_3527  Acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1]
BCGT_1668  Malate synthase G [KO:K01638] [EC:2.3.3.9]
BCGT_1072  Malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
BCGT_0697  Citrate synthase (si) [KO:K01647] [EC:2.3.3.1]
BCGT_0704  Citrate synthase (si) [KO:K01647] [EC:2.3.3.1]
BCGT_0959  2-methylcitrate synthase [KO:K01659] [EC:2.3.3.5]
BCGT_1313  Aconitate hydratase, 2-methylisocitrate dehydratase [KO:K27802] [EC:4.2.1.3 4.2.1.99]
BCGT_0664  3-ketoacyl-CoA thiolase [isoleucine degradation] [KO:K00626] [EC:2.3.1.9]
BCGT_3386  3-ketoacyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
BCGT_0008  3-ketoacyl-CoA thiolase, Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
BCGT_1157  3-ketoacyl-CoA thiolase, Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
BCGT_0724  3-ketoacyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
BCGT_1700  putative acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
BCGT_3412  putative acetyl-CoA acetyltransferase FadA5 [KO:K00626] [EC:2.3.1.9]
BCGT_3422  putative acetyl-CoA acetyltransferase FadA6 [KO:K00626] [EC:2.3.1.9]
BCGT_0894  3-ketoacyl-CoA thiolase, Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
BCGT_1155  Methylmalonyl-CoA epimerase [KO:K05606] [EC:5.1.99.1]
BCGT_3149  Biotin carboxylase of acetyl-CoA carboxylase [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]
BCGT_3145  propionyl-CoA carboxylase, beta subunit [KO:K27094] [EC:6.4.1.3 6.4.1.- 2.1.3.15]
BCGT_3146  hypothetical protein [KO:K27095]
BCGT_2070  Propionyl-CoA carboxylase beta chain [KO:K18472] [EC:6.4.1.2 6.4.1.3 2.1.3.15]
BCGT_1331  methylmalonyl-CoA mutase, [beta] subunit [KO:K01847] [EC:5.4.99.2]
BCGT_1332  Methylmalonyl-CoA mutase [KO:K01847] [EC:5.4.99.2]
BCGT_2102  putative dehydrogenase [KO:K00104] [EC:1.1.99.14]
BCGT_2055  Phosphoglycolate phosphatase [KO:K01091] [EC:3.1.3.18]
BCGT_2693  Glutamine synthetase family protein [KO:K01915] [EC:6.3.1.2]
BCGT_2038  Glutamine synthetase type I [KO:K01915] [EC:6.3.1.2]
BCGT_2041  Glutamine synthetase type I [KO:K01915] [EC:6.3.1.2]
BCGT_1712  Glutamine synthetase [KO:K01915] [EC:6.3.1.2]
BCGT_0922  Serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
BCGT_3863  Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BCGT_1662  Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) [KO:K00281] [EC:1.4.4.2]
BCGT_2028  Aminomethyltransferase (glycine cleavage system T protein) [KO:K00605] [EC:2.1.2.10]
BCGT_0236  Dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BCGT_1657  Glycine cleavage system H protein [KO:K02437]
BCGT_2023  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
BCGT_1081  Dihydrolipoamide succinyltransferase component (E2/E1) of 2-oxoglutarate dehydrogenase complex [KO:K01616] [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
BCGT_2801  Formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
BCGT_3916  putative oxalyl-CoA decarboxylase [KO:K01577] [EC:4.1.1.8]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
mbx00010  Glycolysis / Gluconeogenesis
mbx00020  Citrate cycle (TCA cycle)
mbx00030  Pentose phosphate pathway
mbx00053  Ascorbate and aldarate metabolism
mbx00071  Fatty acid degradation
mbx00230  Purine metabolism
mbx00250  Alanine, aspartate and glutamate metabolism
mbx00260  Glycine, serine and threonine metabolism
mbx00620  Pyruvate metabolism
mbx00710  Carbon fixation by Calvin cycle
mbx00750  Vitamin B6 metabolism
mbx00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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