KEGG   PATHWAY: mgr00260
Entry
mgr00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Pyricularia oryzae
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
mgr00260  Glycine, serine and threonine metabolism
mgr00260

Module
mgr_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:mgr00260]
mgr_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:mgr00260]
mgr_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:mgr00260]
mgr_M00621  Glycine cleavage system [PATH:mgr00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pyricularia oryzae [GN:mgr]
Gene
MGG_11805  lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
MGG_03051  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
MGG_11450  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
MGG_09550  homoserine kinase [KO:K00872] [EC:2.7.1.39]
MGG_08923  threonine synthase [KO:K01733] [EC:4.2.3.1]
MGG_03889  threonine synthase [KO:K01733] [EC:4.2.3.1]
MGG_11389  threonine aldolase [KO:K01620] [EC:4.1.2.48]
MGG_13781  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
MGG_00923  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
MGG_02525  alanine-glyoxylate aminotransferase 1 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
MGG_13763  glycerate kinase [KO:K00865] [EC:2.7.1.165]
MGG_00901  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
MGG_06149  hypothetical protein [KO:K15918] [EC:2.7.1.31]
MGG_11794  D-3-phosphoglycerate dehydrogenase 2 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
MGG_07207  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
MGG_04059  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
MGG_03661  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
MGG_07076  oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
MGG_06446  5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
MGG_14815  flavin-containing amine oxidase [KO:K00274] [EC:1.4.3.4]
MGG_16538  hypothetical protein [KO:K00274] [EC:1.4.3.4]
MGG_10751  peroxisomal copper amine oxidase [KO:K00276] [EC:1.4.3.21]
MGG_05808  peroxisomal copper amine oxidase [KO:K00276] [EC:1.4.3.21]
MGG_03332  copper amine oxidase 1 [KO:K00276] [EC:1.4.3.21]
MGG_13291  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
MGG_15019  peroxisomal copper amine oxidase [KO:K00276] [EC:1.4.3.21]
MGG_09602  hypothetical protein [KO:K00276] [EC:1.4.3.21]
MGG_15038  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
MGG_04826  glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
MGG_17072  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MGG_04861  glycine cleavage system H protein [KO:K02437]
MGG_08011  D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
MGG_15667  hypothetical protein [KO:K00273] [EC:1.4.3.3]
MGG_03550  CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
MGG_09456  betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
MGG_12421  aminomethyltransferase [KO:K00309] [EC:1.5.3.10]
MGG_07384  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
MGG_10380  cystathionine-gamma-lyase [KO:K01758] [EC:4.4.1.1]
MGG_07224  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
MGG_09501  serine racemase [KO:K01754] [EC:4.3.1.19]
MGG_17828  hypothetical protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
MGG_06950  L-serine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
MGG_15402  hypothetical protein [KO:K20498] [EC:4.3.1.18]
MGG_12805  tryptophan synthase [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
mgr00010  Glycolysis / Gluconeogenesis
mgr00020  Citrate cycle (TCA cycle)
mgr00230  Purine metabolism
mgr00250  Alanine, aspartate and glutamate metabolism
mgr00270  Cysteine and methionine metabolism
mgr00290  Valine, leucine and isoleucine biosynthesis
mgr00300  Lysine biosynthesis
mgr00330  Arginine and proline metabolism
mgr00460  Cyanoamino acid metabolism
mgr00470  D-Amino acid metabolism
mgr00564  Glycerophospholipid metabolism
mgr00600  Sphingolipid metabolism
mgr00620  Pyruvate metabolism
mgr00630  Glyoxylate and dicarboxylate metabolism
mgr00640  Propanoate metabolism
mgr00680  Methane metabolism
mgr00860  Porphyrin metabolism
mgr00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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