KEGG   PATHWAY: mju00983
Entry
mju00983                    Pathway                                
Name
Drug metabolism - other enzymes - Maniola jurtina (meadow brown)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
mju00983  Drug metabolism - other enzymes
mju00983

Organism
Maniola jurtina (meadow brown) [GN:mju]
Gene
123865995  inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
123874066  GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
123869419  xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123869421  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123872921  indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123872923  indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123873115  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123873116  xanthine dehydrogenase 1-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123873117  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123873118  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123873119  indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123873120  xanthine dehydrogenase 1-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123873121  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123873139  probable aldehyde oxidase gad-3 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123873140  LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123873263  indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123873299  xanthine dehydrogenase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123873431  indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123868244  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
123865041  UDP-glycosyltransferase UGT4-like [KO:K00699] [EC:2.4.1.17]
123865042  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
123875030  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
123865278  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
123865703  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
123875324  UDP-glucosyltransferase 2 isoform X1 [KO:K00699] [EC:2.4.1.17]
123865704  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
123865705  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
123865706  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
123865709  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
123876964  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
123876965  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
123876967  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
123877105  uncharacterized protein LOC123877105 [KO:K00699] [EC:2.4.1.17]
123878794  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
123869371  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
123880111  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
123869702  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
123870807  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
123872589  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
123872590  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
123873276  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
123873277  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
123873278  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
123872822  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
123873872  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
123872109  dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
123877386  dihydropyrimidinase isoform X1 [KO:K01464] [EC:3.5.2.2]
123874239  beta-ureidopropionase-like [KO:K01431] [EC:3.5.1.6]
123874491  beta-ureidopropionase-like [KO:K01431] [EC:3.5.1.6]
123874492  beta-ureidopropionase-like [KO:K01431] [EC:3.5.1.6]
123865476  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
123869814  uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
123864960  uridine-cytidine kinase isoform X1 [KO:K00876] [EC:2.7.1.48]
123868074  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
123871893  uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
123876001  UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
123869539  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
123874593  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
123874103  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
123864969  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
123876022  nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
123876053  nucleoside diphosphate kinase 7-like [KO:K00940] [EC:2.7.4.6]
123876754  deoxyuridine 5'-triphosphate nucleotidohydrolase [KO:K01520] [EC:3.6.1.23]
123864444  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
123864446  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
123864447  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
123874573  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
123875759  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
123875931  glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
123875932  glutathione S-transferase E14-like isoform X1 [KO:K00799] [EC:2.5.1.18]
123866749  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
123868937  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
123868956  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
123868958  glutathione S-transferase 1-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
123869145  glutathione S-transferase 1-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
123879827  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
123870012  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
123872726  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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