KEGG   PATHWAY: morg00980
Entry
morg00980                   Pathway                                
Name
Metabolism of xenobiotics by cytochrome P450 - Microtus oregoni (creeping vole)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
morg00980  Metabolism of xenobiotics by cytochrome P450
morg00980

Organism
Microtus oregoni (creeping vole) [GN:morg]
Gene
121445349  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
121432953  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
121454117  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
121454276  Gsto1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
121454595  glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
121455456  Mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
121452882  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
121452929  Mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
121466001  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
121466002  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
121466003  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
121466058  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
121466059  glutathione S-transferase A2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
121466100  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
121466106  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
121466110  glutathione S-transferase A2 isoform X1 [KO:K00799] [EC:2.5.1.18]
121466123  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
121466126  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
121450740  glutathione S-transferase alpha-3 [KO:K00799] [EC:2.5.1.18]
121450779  glutathione S-transferase alpha-3-like [KO:K00799] [EC:2.5.1.18]
121450871  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
121437837  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
121437838  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
121437849  glutathione S-transferase Mu 2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
121437851  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
121437862  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
121437864  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
121437865  glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
121437869  glutathione S-transferase Mu 5 [KO:K00799] [EC:2.5.1.18]
121437892  glutathione S-transferase Mu 6 [KO:K00799] [EC:2.5.1.18]
121445615  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
121445621  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
121445622  glutathione S-transferase theta-3 [KO:K00799] [EC:2.5.1.18]
121451054  glutathione S-transferase A6 isoform X1 [KO:K00799] [EC:2.5.1.18]
121437991  glutathione S-transferase Mu 7 [KO:K00799] [EC:2.5.1.18]
121437992  glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
121438021  Mgst1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
121446269  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
121446276  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
121446284  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
121446286  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
121446771  glutathione S-transferase Mu 5 [KO:K00799] [EC:2.5.1.18]
121440061  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
121448764  glutathione S-transferase Mu 2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
121448897  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
121449022  glutathione S-transferase Mu 7 [KO:K00799] [EC:2.5.1.18]
121449108  glutathione S-transferase Mu 6 [KO:K00799] [EC:2.5.1.18]
121449179  glutathione S-transferase Mu 2-like [KO:K00799] [EC:2.5.1.18]
121449253  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
121449564  glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
121454159  glutathione S-transferase P isoform X1 [KO:K23790] [EC:2.5.1.18]
121454468  glutathione S-transferase P-like isoform X1 [KO:K23790] [EC:2.5.1.18]
121455227  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121463946  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121458543  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121464850  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121452712  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121459291  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
121465360  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121465383  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121453635  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121436401  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
121444537  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121450805  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
121441244  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121441256  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121441261  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121441267  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121441288  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121441302  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121441304  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121441538  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121441597  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121449222  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
121449559  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
121435493  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
121435506  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
121435511  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
121443234  Hpgds; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
121435840  epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
121435939  epoxide hydrolase 1-like [KO:K01253] [EC:3.3.2.9]
121449068  sulfotransferase 2A1-like isoform X1 [KO:K11822] [EC:2.8.2.14]
121449462  sulfotransferase 2A1-like [KO:K11822] [EC:2.8.2.14]
121449475  sulfotransferase 2A1-like [KO:K11822] [EC:2.8.2.14]
121449499  sulfotransferase 2A1-like [KO:K11822] [EC:2.8.2.14]
121449521  sulfotransferase 2A1-like [KO:K11822] [EC:2.8.2.14]
121449541  sulfotransferase 2A1-like [KO:K11822] [EC:2.8.2.14]
121445350  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
121445351  cytochrome P450 1A2-like [KO:K07409] [EC:1.14.14.1]
121445352  cytochrome P450 1A2-like [KO:K07409] [EC:1.14.14.1]
121457665  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
121449580  cytochrome P450 2F2 [KO:K07416] [EC:1.14.14.1]
121450219  cytochrome P450 2S1 [KO:K07420] [EC:1.14.14.1]
121449119  Dhdh; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase [KO:K00078] [EC:1.3.1.20 1.1.1.179]
121435825  Hsd11b1; corticosteroid 11-beta-dehydrogenase isozyme 1 [KO:K15680] [EC:1.1.1.146]
121461792  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
121461815  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
121461961  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
121444134  carbonyl reductase [NADPH] 2 isoform X1 [KO:K00081] [EC:1.1.1.184]
121444140  carbonyl reductase [NADPH] 2-like isoform X1 [KO:K00081] [EC:1.1.1.184]
121444651  carbonyl reductase [NADPH] 2 isoform X1 [KO:K00081] [EC:1.1.1.184]
121444652  carbonyl reductase [NADPH] 2-like isoform X1 [KO:K00081] [EC:1.1.1.184]
121461827  Cbr3; carbonyl reductase [NADPH] 3 [KO:K00084] [EC:1.1.1.184]
121460674  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
121460703  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
121460704  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
121460705  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
121460706  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
121460707  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
121460722  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
121460723  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
121460730  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
121460734  UDP-glucuronosyltransferase 2B17-like isoform X1 [KO:K00699] [EC:2.4.1.17]
121460735  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
121460758  UDP-glucuronosyltransferase 2B1 [KO:K00699] [EC:2.4.1.17]
121460764  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
121460803  UDP-glucuronosyltransferase 2A2 isoform X1 [KO:K00699] [EC:2.4.1.17]
121460818  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
121460879  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
121460913  UDP-glucuronosyltransferase 2B17-like isoform X1 [KO:K00699] [EC:2.4.1.17]
121446879  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
121446881  UDP-glucuronosyltransferase 1A7-like [KO:K00699] [EC:2.4.1.17]
121447020  UDP-glucuronosyltransferase 1A7-like [KO:K00699] [EC:2.4.1.17]
121447314  UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
121447552  UDP-glucuronosyltransferase 1A1 isoform X1 [KO:K00699] [EC:2.4.1.17]
121447554  UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
121447555  UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
121447909  aflatoxin B1 aldehyde reductase member 2 [KO:K15303]
121447910  aflatoxin B1 aldehyde reductase member 3 isoform X1 [KO:K15303]
121448319  aflatoxin B1 aldehyde reductase member 3-like [KO:K15303]
121454242  Aldh3b1; aldehyde dehydrogenase family 3 member B1 isoform X1 [KO:K00129] [EC:1.2.1.5]
121454501  aldehyde dehydrogenase family 3 member B3 isoform X1 [KO:K00129] [EC:1.2.1.5]
121456346  Aldh3a1; aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00129] [EC:1.2.1.5]
121453982  aldehyde dehydrogenase family 3 member B2 [KO:K00129] [EC:1.2.1.5]
121445963  alcohol dehydrogenase 1-like [KO:K13951] [EC:1.1.1.1]
121446657  alcohol dehydrogenase 1-like [KO:K13951] [EC:1.1.1.1]
121446978  alcohol dehydrogenase 1 [KO:K13951] [EC:1.1.1.1]
121446988  alcohol dehydrogenase 1-like [KO:K13951] [EC:1.1.1.1]
121450079  LOW QUALITY PROTEIN: all-trans-retinol dehydrogenase [NAD(+)] ADH7-like [KO:K13951] [EC:1.1.1.1]
121450014  all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
121446608  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
121450022  alcohol dehydrogenase 6 [KO:K13952] [EC:1.1.1.1]
Compound
C00745  Nicotine
C00829  Naphthalene
C02617  1,4-Naphthoquinone
C03012  Naphthalene-1,2-diol
C06205  1,2-Dihydronaphthalene-1,2-diol
C06755  Chloroacetic acid
C06790  Trichloroethene
C06800  Aflatoxin B1
C06899  Chloral hydrate
C07490  Trichloroethanol
C07535  Benzo[a]pyrene
C11036  Bromobenzene
C11088  1,2-Dibromoethane
C11148  TCE epoxide
C11149  Dichloroacetate
C11150  Trichloroacetate
C11278  Aflatoxin B1exo-8,9-epoxide-GSH
C11713  2-Naphthol
C11714  1-Naphthol
C14039  1,1-Dichloroethylene
C14040  1-Nitronaphthalene
C14453  4-Bromophenol
C14556  9-Hydroxybenzo[a]pyrene
C14783  1,2-Naphthoquinone
C14784  1,2-Dihydroxy-3,4-epoxy-1,2,3,4-tetrahydronaphthalene
C14785  1,4-Dihydroxynaphthalene
C14786  (1R,2S)-Naphthalene 1,2-oxide
C14787  (1S,2R)-Naphthalene 1,2-oxide
C14788  1-Nitrosonaphthalene
C14789  N-Hydroxy-1-aminonaphthalene
C14790  1-Naphthylamine
C14791  (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
C14792  (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
C14793  (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
C14796  (1R)-Hydroxy-(2R)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
C14797  (1R)-N-Acetyl-L-cysteinyl-(2R)-hydroxy-1,2-dihydronaphthalene
C14798  (1S)-Hydroxy-(2S)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
C14799  (1R,2R)-3-[(1,2-Dihydro-2-hydroxy-1-naphthalenyl)thio]-2-oxopropanoic acid
C14800  1-Nitronaphthalene-5,6-oxide
C14801  1-Nitro-5,6-dihydroxy-dihydronaphthalene
C14802  1-Nitronaphthalene-7,8-oxide
C14803  1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene
C14804  1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene
C14805  1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene
C14806  1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene
C14839  Bromobenzene-3,4-oxide
C14840  Bromobenzene-2,3-oxide
C14841  2-Bromophenol
C14842  Bromobenzene-2,3-dihydrodiol
C14843  4-Bromocatechol
C14844  Bromobenzene-3,4-dihydrodiol
C14845  4-Bromophenol-2,3-epoxide
C14846  4-Bromo-3,5-cyclohexadiene-1,2-dione
C14847  3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene
C14848  2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene
C14849  Benzo[a]pyrene-9,10-oxide
C14850  Benzo[a]pyrene-7,8-oxide
C14851  Benzo[a]pyrene-4,5-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C14853  Benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide
C14854  9-Hydroxybenzo[a]pyrene-4,5-oxide
C14855  4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene
C14856  7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene
C14857  1,1-Dichloroethylene epoxide
C14858  2,2-Dichloroacetaldehyde
C14859  Chloroacetyl chloride
C14860  2,2-Dichloro-1,1-ethanediol
C14861  S-(2,2-Dichloro-1-hydroxy)ethyl glutathione
C14862  2-S-Glutathionyl acetate
C14863  2-(S-Glutathionyl)acetyl glutathione
C14864  S-(2-Chloroacetyl)glutathione
C14865  2-(S-Glutathionyl)acetyl chloride
C14866  Chloral
C14867  Dichloroacetyl chloride
C14868  S-(1,2-Dichlorovinyl)glutathione
C14869  Trichloroethanol glucuronide
C14870  2-Bromoacetaldehyde
C14871  S-(Formylmethyl)glutathione
C14872  Thiodiacetic acid
C14873  Thiodiacetic acid sulfoxide
C14874  Glutathione episulfonium ion
C14875  S-(2-Hydroxyethyl)glutathione
C14876  S-(2-Hydroxyethyl)-N-acetyl-L-cysteine
C14877  S-[2-(N7-Guanyl)ethyl]-N-acetyl-L-cysteine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16756  Aflatoxin M1
C19488  7,12-Dimethylbenz[a]anthracene
C19489  1a,11b-Dihydro-4,9-dimethylbenz[a]anthra[3,4-b]oxirene
C19490  trans-3,4-Dihydro-3,4-dihydroxy-7,12-dimethylbenz[a]anthracene
C19559  (1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-Tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol
C19561  7-Hydroxymethyl-12-methylbenz[a]anthracene
C19562  7-Hydroxymethyl-12-methylbenz[a]anthracene sulfate
C19563  4-[(Hydroxymethyl)nitrosoamino]-1-(3-pyridinyl)-1-butanone
C19564  4-(Nitrosoamino)-1-(3-pyridinyl)-1-butanone
C19565  4-Hydroxy-1-(3-pyridinyl)-1-butanone
C19566  4-Hydroxy-4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone
C19567  4-Oxo-1-(3-pyridyl)-1-butanone
C19568  N-Nitrosomethanamine
C19569  3-Succinoylpyridine
C19574  4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
C19577  1-(Methylnitrosoamino)-4-(3-pyridinyl)-1,4-butanediol
C19578  5-(3-Pyridyl)-2-hydroxytetrahydrofuran
C19579  gamma-Hydroxy-3-pyridinebutanoate
C19580  alpha-[3-[(Hydroxymethyl)nitrosoamino]propyl]-3-pyridinemethanol
C19581  alpha-[3-(Nitrosoamino)propyl]-3-pyridinemethanol
C19582  1-(3-Pyridinyl)-1,4-butanediol
C19585  Aflatoxin Q1
C19586  Aflatoxin B1-exo-8,9-epoxide
C19588  Aflatoxin B1 diol
C19589  Aflatoxin B1 dialdehyde
C19590  6-[2,3-Dihydroxy-1-(hydroxymethyl)propyl]-1,2-dihydro-7-hydroxy-9-methoxy-cyclopenta[c][1]benzopyran-3,4-dione
C19591  1,2,3,4-Tetrahydro-alpha,7-dihydroxy-beta-(hydroxymethyl)-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-propanal
C19592  alpha-(1,2-Dihydroxyethyl)-1,2,3,4-tetrahydro-7-hydroxy-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-acetaldehyde
C19594  Aflatoxin-M1-8,9-epoxide
C19595  Aflatoxin B1-endo-8,9-epoxide
C19602  4-(Methylnitrosamino)-1-(1-oxido-3-pyridinyl)-1-butanone
C19603  4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol
C19604  7,12-Dimethylbenz[a]anthracene 5,6-oxide
C19605  4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronide
C19606  NNAL-N-glucuronide
C19607  trans-5,6-Dihydro-5,6-dihydroxy-7,12-dimethylbenz[a]anthracene
Reference
PMID:12487150
  Authors
Buckpitt A, Boland B, Isbell M, Morin D, Shultz M, Baldwin R, Chan K, Karlsson A, Lin C, Taff A, West J, Fanucchi M, Van Winkle L, Plopper C.
  Title
Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity.
  Journal
Drug Metab Rev 34:791-820 (2002)
DOI:10.1081/DMR-120015694
Reference
PMID:10725110
  Authors
Bolton JL, Trush MA, Penning TM, Dryhurst G, Monks TJ.
  Title
Role of quinones in toxicology.
  Journal
Chem Res Toxicol 13:135-60 (2000)
DOI:10.1021/tx9902082
Reference
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