KEGG   PATHWAY: msg00230
Entry
msg00230                    Pathway                                
Name
Purine metabolism - Mycolicibacterium smegmatis MC2 155
Class
Metabolism; Nucleotide metabolism
Pathway map
msg00230  Purine metabolism
msg00230

Module
msg_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:msg00230]
msg_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:msg00230]
msg_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:msg00230]
msg_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:msg00230]
msg_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:msg00230]
msg_M00546  Purine degradation, xanthine => urea [PATH:msg00230]
msg_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:msg00230]
msg_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:msg00230]
Other DBs
GO: 0006163 0042278
Organism
Mycolicibacterium smegmatis MC2 155 [GN:msg]
Gene
MSMEI_2087  pgmA; Phosphoglucomutase PgmA [KO:K01835] [EC:5.4.2.2]
MSMEI_5278  prs; Ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
MSMEI_5646  purF; Amidophosphoribosyltransferase purF [KO:K00764] [EC:2.4.2.14]
MSMEI_5694  purD; Phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
MSMEI_5364  purN; 5'-phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
MSMEI_0750  purT; putative phosphoribosylglycinamide formyltransferase 2 Purt [KO:K08289] [EC:6.3.1.21]
MSMEI_5135  Phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
MSMEI_5666  purL; Phosphoribosylformylglycinamidine synthase II [KO:K23269] [EC:6.3.5.3]
MSMEI_5674  Phosphoribosylformylglycinamidine synthase, purS [KO:K23264] [EC:6.3.5.3]
MSMEI_5673  purQ; Phosphoribosylformylglycinamidine synthase 1 [KO:K23265] [EC:6.3.5.3 3.5.1.2]
MSMEI_5644  purM; Phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
MSMEI_1776  purK; Phosphoribosylaminoimidazole carboxylase ATPase subunit [KO:K01589] [EC:6.3.4.18]
MSMEI_1777  purE; Phosphoribosylaminoimidazole carboxylase catalytic subunit purE [KO:K01588] [EC:5.4.99.18]
MSMEI_5683  Phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
MSMEI_5689  purB; Adenylosuccinate lyase purB [KO:K01756] [EC:4.3.2.2]
MSMEI_5363  purH; Bifunctional purine biosynthesis protein purH : phosphoribosylaminoimidazolecarboxamide formyltransferase + inosinemonophosphate cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
MSMEI_2890  apt; Adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
MSMEI_6639  5'-nucleotidase surE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
MSMEI_2389  HAD-superfamily hydrolase, subfamily IIA [KO:K02566] [EC:3.1.3.5]
MSMEI_1661  punA; Purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
MSMEI_4123  YfiH [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
MSMEI_1584  iunH; Inosine-uridine nucleoside hydrolase, IunH [KO:K01239] [EC:3.2.2.1]
MSMEI_5951  hpt; Hypoxanthine-guanine phosphoribosyltransferase hpt [KO:K00760] [EC:2.4.2.8]
MSMEI_1563  guaB; Inosine-5'-monophosphate (Imp) dehydrogenase, GuaB2 [KO:K00088] [EC:1.1.1.205]
MSMEI_1564  Inosine-5'-monophosphate (Imp) dehydrogenase, GuaB3 [KO:K00088] [EC:1.1.1.205]
MSMEI_4510  Nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
MSMEI_4773  Nucleoside-triphosphatase [KO:K01519] [EC:3.6.1.66]
MSMEI_0667  Aldehyde oxidase and xanthine dehydrogenase molybdopterin binding protein [KO:K11177] [EC:1.17.1.4]
MSMEI_0850  Aldehyde oxidase and xanthine dehydrogenase, a/b [KO:K11177] [EC:1.17.1.4]
MSMEI_0668  Molybdopterin dehydrogenase, FAD-binding protein [KO:K11178] [EC:1.17.1.4]
MSMEI_0851  Molybdopterin dehydrogenase FAD-binding protein [KO:K11178] [EC:1.17.1.4]
MSMEI_0669  (2Fe-2S)-binding protein [KO:K13483]
MSMEI_0852  (2Fe-2S)-binding protein [KO:K13483]
MSMEI_1571  guaA; GMP synthase glutamine-hydrolyzing [KO:K01951] [EC:6.3.5.2]
MSMEI_3548  Inosine-5-monophosphate dehydrogenase guaB1 [KO:K26110] [EC:1.7.1.7]
MSMEI_1260  putative guanine deaminase [KO:K01487] [EC:3.5.4.3]
MSMEI_2976  gmk; Guanylate kinase Gmk [KO:K00942] [EC:2.7.4.8]
MSMEI_2241  nrdE; Ribonucleoside-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
MSMEI_0990  nrdE; Ribonucleoside-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
MSMEI_2253  nrdF2; Ribonucleoside-diphosphate reductase beta chain [KO:K00526] [EC:1.17.4.1]
MSMEI_1002  nrdF2; Ribonucleoside-diphosphate reductase beta chain [KO:K00526] [EC:1.17.4.1]
MSMEI_0351  nrdB; Ribonucleoside-diphosphate reductase subunit beta NrdB [KO:K00526] [EC:1.17.4.1]
MSMEI_4372  dgt; Deoxyguanosinetriphosphate triphosphohydrolase-like protein [KO:K01129] [EC:3.1.5.1]
MSMEI_2891  relA; GTP pyrophosphokinase RelA [KO:K01139] [EC:2.7.6.5 3.1.7.2]
MSMEI_0916  Exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
MSMEI_5265  Ppx/GppA phosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
MSMEI_3160  hypothetical protein [KO:K01768] [EC:4.6.1.1]
MSMEI_4890  Adenylate/guanylate cyclase [KO:K01768] [EC:4.6.1.1]
MSMEI_5997  Adenylate/guanylate cyclase [KO:K01768] [EC:4.6.1.1]
MSMEI_0221  Adenylate/guanylate cyclase [KO:K01768] [EC:4.6.1.1]
MSMEI_0743  purA; Adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
MSMEI_4169  adoK; Carbohydrate kinase CbhK [KO:K00856] [EC:2.7.1.20]
MSMEI_1635  add; Adenosine deaminase [KO:K01488] [EC:3.5.4.4]
MSMEI_1448  adk; Adenylate kinase [KO:K00939] [EC:2.7.4.3]
MSMEI_5273  MazG nucleotide pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
MSMEI_2858  Histidine triad (HIT) protein [KO:K19710] [EC:2.7.7.53]
MSMEI_4851  Adenylylsulfate kinase / sulfate adenylyltransferase subunit 1 [KO:K00955] [EC:2.7.7.4 2.7.1.25]
MSMEI_4852  Sulfate adenylyltransferase subunit 2 CysD [KO:K00957] [EC:2.7.7.4]
MSMEI_1258  Uricase [KO:K00365] [EC:1.7.3.3]
MSMEI_1257  Transthyretin [KO:K07127] [EC:3.5.2.17]
MSMEI_1256  Putative allantoicase (Allantoate amidinohydrolase) [KO:K16840] [EC:4.1.1.97]
MSMEI_5956  hypothetical protein [KO:K16840] [EC:4.1.1.97]
MSMEI_5577  Asp/Glu/hydantoin racemase [KO:K16841] [EC:5.1.99.3]
MSMEI_5576  Urate catabolism protein (Polysaccharide deacetylase family protein) [KO:K16842] [EC:3.5.2.5]
MSMEI_5575  Allantoicase Alc [KO:K01477] [EC:3.5.3.4]
MSMEI_1062  Urease alpha subunit, (Urea amidohydrolase alpha subunit) [KO:K01428] [EC:3.5.1.5]
MSMEI_3540  ureC; Urease subunit alpha [KO:K01428] [EC:3.5.1.5]
MSMEI_3541  ureB; Urease subunit beta [KO:K01429] [EC:3.5.1.5]
MSMEI_3542  ureA; Urease subunit gamma [KO:K01430] [EC:3.5.1.5]
MSMEI_1061  Urease beta/gamma subunit [KO:K14048] [EC:3.5.1.5]
MSMEI_1576  Gamma-glutamyltranspeptidase [KO:K22602] [EC:3.5.1.126]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
msg00030  Pentose phosphate pathway
msg00220  Arginine biosynthesis
msg00250  Alanine, aspartate and glutamate metabolism
msg00260  Glycine, serine and threonine metabolism
msg00340  Histidine metabolism
msg00630  Glyoxylate and dicarboxylate metabolism
msg00730  Thiamine metabolism
msg00740  Riboflavin metabolism
msg00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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