KEGG   PATHWAY: msin00053
Entry
msin00053                   Pathway                                
Name
Ascorbate and aldarate metabolism - Magnolia sinica
Class
Metabolism; Carbohydrate metabolism
Pathway map
msin00053  Ascorbate and aldarate metabolism
msin00053

Module
msin_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:msin00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Magnolia sinica [GN:msin]
Gene
131219277  UDP-glucose 6-dehydrogenase 3 [KO:K00012] [EC:1.1.1.22]
131229240  UDP-glucose 6-dehydrogenase 3-like [KO:K00012] [EC:1.1.1.22]
131246467  UDP-glucose 6-dehydrogenase 4-like [KO:K00012] [EC:1.1.1.22]
131221063  UDP-sugar pyrophosphorylase-like isoform X1 [KO:K12447] [EC:2.7.7.64]
131226735  UDP-sugar pyrophosphorylase-like [KO:K12447] [EC:2.7.7.64]
131243550  glucuronokinase 1-like [KO:K16190] [EC:2.7.1.43]
131251493  uncharacterized protein LOC131251493 [KO:K00469] [EC:1.13.99.1]
131216988  inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
131217000  probable inositol oxygenase [KO:K00469] [EC:1.13.99.1]
131217005  probable inositol oxygenase [KO:K00469] [EC:1.13.99.1]
131236911  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
131243833  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
131248623  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
131237564  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
131224121  probable truncated L-gulonolactone oxidase 7, mitochondrial [KO:K00103] [EC:1.1.3.8]
131227428  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
131227445  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
131230426  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
131230435  L-gulonolactone oxidase 2-like [KO:K00103] [EC:1.1.3.8]
131230441  probable truncated L-gulonolactone oxidase 7, mitochondrial [KO:K00103] [EC:1.1.3.8]
131233596  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
131248929  GDP-mannose 3,5-epimerase 2 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
131232682  GDP-mannose 3,5-epimerase 2-like [KO:K10046] [EC:5.1.3.18 5.1.3.-]
131251291  GDP-L-galactose phosphorylase 2-like isoform X1 [KO:K14190] [EC:2.7.7.69]
131240707  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
131244363  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
131219545  inositol monophosphatase 3 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
131237920  bifunctional phosphatase IMPL2, chloroplastic isoform X1 [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
131218786  L-galactose dehydrogenase [KO:K17744] [EC:1.1.1.316]
131236723  L-galactono-1,4-lactone dehydrogenase, mitochondrial [KO:K00225] [EC:1.3.2.3]
131248372  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
131239600  UDP-glucuronate 4-epimerase 6 [KO:K08679] [EC:5.1.3.6]
131256876  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
131233093  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
131217095  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
131235712  monodehydroascorbate reductase [KO:K08232] [EC:1.6.5.4]
131237829  monodehydroascorbate reductase 4, peroxisomal [KO:K08232] [EC:1.6.5.4]
131232485  monodehydroascorbate reductase, chloroplastic/mitochondrial [KO:K08232] [EC:1.6.5.4]
131236620  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
131223134  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
131251334  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
131239642  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
131253258  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
131229519  probable L-ascorbate peroxidase 4, peroxisomal [KO:K00434] [EC:1.11.1.11]
131251438  glutathione S-transferase DHAR3, chloroplastic-like isoform X1 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
131253021  probable glutathione S-transferase DHAR1, cytosolic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
131243575  glutathione S-transferase DHAR2-like isoform X1 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
131223728  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
131218380  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
131236621  aldehyde dehydrogenase family 3 member H1 [KO:K00128] [EC:1.2.1.3]
131251183  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
131251188  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
131224303  aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
131253442  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
131255566  aldehyde dehydrogenase family 2 member B7, mitochondrial-like isoform X1 [KO:K00128] [EC:1.2.1.3]
131255571  aldehyde dehydrogenase family 2 member B7, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
131227701  aldehyde dehydrogenase family 3 member F1-like isoform X1 [KO:K00128] [EC:1.2.1.3]
131257948  benzaldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
131251734  aldehyde dehydrogenase family 7 member B4 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
msin00020  Citrate cycle (TCA cycle)
msin00040  Pentose and glucuronate interconversions
msin00051  Fructose and mannose metabolism
msin00520  Amino sugar and nucleotide sugar metabolism
msin00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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