KEGG   PATHWAY: mtq00230
Entry
mtq00230                    Pathway                                
Name
Purine metabolism - Mycobacterium tuberculosis HKBS1
Class
Metabolism; Nucleotide metabolism
Pathway map
mtq00230  Purine metabolism
mtq00230

Module
mtq_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:mtq00230]
mtq_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:mtq00230]
mtq_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:mtq00230]
mtq_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:mtq00230]
mtq_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:mtq00230]
Other DBs
GO: 0006163 0042278
Organism
Mycobacterium tuberculosis HKBS1 [GN:mtq]
Gene
HKBS1_3234  pgmA; phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
HKBS1_1071  prsA; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
HKBS1_0849  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
HKBS1_0811  purD; phosphoribosylamine-glycine ligase [KO:K01945] [EC:6.3.4.13]
HKBS1_1006  purN; 5-phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
HKBS1_0404  purT; phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
HKBS1_0844  purL; phosphoribosylformylglycinamidine synthase II [KO:K23269] [EC:6.3.5.3]
HKBS1_0828  hypothetical protein [KO:K23264] [EC:6.3.5.3]
HKBS1_0829  purG; phosphoribosylformylglycinamidine synthase I [KO:K23265] [EC:6.3.5.3 3.5.1.2]
HKBS1_0850  purM; phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
HKBS1_3465  purK; phosphoribosylaminoimidazole carboxylase ATPase subunit [KO:K01589] [EC:6.3.4.18]
HKBS1_3463  purE; phosphoribosylaminoimidazole carboxylase catalytic subunit [KO:K01588] [EC:5.4.99.18]
HKBS1_0819  purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
HKBS1_0816  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
HKBS1_1007  purH; bifunctional purine biosynthesis protein [KO:K00602] [EC:2.1.2.3 3.5.4.10]
HKBS1_2733  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
HKBS1_3495  deoD; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
HKBS1_2275  yfiH; yfiH [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
HKBS1_3593  iunH; inosine-uridine preferring nucleoside hydrolase [KO:K01239] [EC:3.2.2.1]
HKBS1_3837  hpt; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
HKBS1_3611  guaB3; inosine 5-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
HKBS1_3612  guaB2; inosine 5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
HKBS1_2591  ndk; nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
HKBS1_1429  putative deoxyribonucleotide triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
HKBS1_3597  guaA; GMP synthase [KO:K01951] [EC:6.3.5.2]
HKBS1_1936  guaB1; inosine 5-monophosphate dehydrogenase [KO:K26110] [EC:1.7.1.7]
HKBS1_1483  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
HKBS1_3217  nrdE; ribonucleotide-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
HKBS1_0594  putative ribonucleoside-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
HKBS1_3214  nrdF2; ribonucleotide-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
HKBS1_0249  nrdB; ribonucleoside-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
HKBS1_2087  nrdF1; ribonucleotide-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
HKBS1_2479  dgt; deoxyguanosinetriphosphate triphosphohydrolase-like protein [KO:K01129] [EC:3.1.5.1]
HKBS1_2732  relA; GTP pyrophosphokinase RelA [KO:K01139] [EC:2.7.6.5 3.1.7.2]
HKBS1_1080  hypothetical protein [KO:K01524] [EC:3.6.1.11 3.6.1.40]
HKBS1_0517  hypothetical protein [KO:K01524] [EC:3.6.1.11 3.6.1.40]
HKBS1_1347  putative adenylate cyclase [KO:K01768] [EC:4.6.1.1]
HKBS1_1718  cya; membrane-anchored adenylyl cyclase Cya [KO:K01768] [EC:4.6.1.1]
HKBS1_3859  putative adenylate cyclase [KO:K01768] [EC:4.6.1.1]
HKBS1_0373  purA; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
HKBS1_2328  cbhK; carbohydrate kinase CbhK [KO:K00856] [EC:2.7.1.20]
HKBS1_3503  add; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
HKBS1_0769  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
HKBS1_1075  mazG; nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
HKBS1_0846  hypothetical protein [KO:K03651] [EC:3.1.4.53]
HKBS1_2763  hypothetical protein [KO:K19710] [EC:2.7.7.53]
HKBS1_1370  cysN; bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein [KO:K00955] [EC:2.7.7.4 2.7.1.25]
HKBS1_1369  cysD; sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
HKBS1_1943  ureC; urease subunit alpha [KO:K01428] [EC:3.5.1.5]
HKBS1_1942  ureB; urease subunit beta [KO:K01429] [EC:3.5.1.5]
HKBS1_1941  ureA; urease subunit gamma [KO:K01430] [EC:3.5.1.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mtq00030  Pentose phosphate pathway
mtq00220  Arginine biosynthesis
mtq00250  Alanine, aspartate and glutamate metabolism
mtq00260  Glycine, serine and threonine metabolism
mtq00340  Histidine metabolism
mtq00630  Glyoxylate and dicarboxylate metabolism
mtq00730  Thiamine metabolism
mtq00740  Riboflavin metabolism
mtq00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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