KEGG   PATHWAY: mtur00230
Entry
mtur00230                   Pathway                                
Name
Purine metabolism - Mycobacterium tuberculosis CCDC5079
Class
Metabolism; Nucleotide metabolism
Pathway map
mtur00230  Purine metabolism
mtur00230

Module
mtur_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:mtur00230]
mtur_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:mtur00230]
mtur_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:mtur00230]
mtur_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:mtur00230]
mtur_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:mtur00230]
Other DBs
GO: 0006163 0042278
Organism
Mycobacterium tuberculosis CCDC5079 [GN:mtur]
Gene
CFBS_3236  pgmA; phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
CFBS_1071  prsA; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
CFBS_0849  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
CFBS_0811  purD; phosphoribosylamine-glycine ligase [KO:K01945] [EC:6.3.4.13]
CFBS_1006  purN; 5-phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
CFBS_0404  purT; phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
CFBS_0844  purL; phosphoribosylformylglycinamidine synthase II [KO:K23269] [EC:6.3.5.3]
CFBS_0828  hypothetical protein [KO:K23264] [EC:6.3.5.3]
CFBS_0829  purG; phosphoribosylformylglycinamidine synthase I [KO:K23265] [EC:6.3.5.3 3.5.1.2]
CFBS_0850  purM; phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
CFBS_3468  purK; phosphoribosylaminoimidazole carboxylase ATPase subunit [KO:K01589] [EC:6.3.4.18]
CFBS_3466  purE; phosphoribosylaminoimidazole carboxylase catalytic subunit [KO:K01588] [EC:5.4.99.18]
CFBS_0819  purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
CFBS_0816  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
CFBS_1007  purH; bifunctional purine biosynthesis protein [KO:K00602] [EC:2.1.2.3 3.5.4.10]
CFBS_2735  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
CFBS_3498  deoD; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
CFBS_2278  yfiH; hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
CFBS_3596  iunH; inosine-uridine preferring nucleoside hydrolase [KO:K01239] [EC:3.2.2.1]
CFBS_3840  hpt; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
CFBS_3614  guaB3; inosine 5-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
CFBS_3615  guaB2; inosine 5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
CFBS_2592  ndk; nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
CFBS_1426  putative deoxyribonucleotide triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
CFBS_3600  guaA; GMP synthase [KO:K01951] [EC:6.3.5.2]
CFBS_1935  guaB1; inosine 5-monophosphate dehydrogenase [KO:K26110] [EC:1.7.1.7]
CFBS_1480  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
CFBS_3219  nrdE; ribonucleotide-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
CFBS_0594  putative ribonucleoside-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
CFBS_3216  nrdF2; ribonucleotide-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
CFBS_0249  nrdB; ribonucleoside-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
CFBS_2086  nrdF1; ribonucleotide-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
CFBS_2482  dgt; deoxyguanosinetriphosphate triphosphohydrolase-like protein [KO:K01129] [EC:3.1.5.1]
CFBS_2734  relA; GTP pyrophosphokinase RelA [KO:K01139] [EC:2.7.6.5 3.1.7.2]
CFBS_0517  hypothetical protein [KO:K01524] [EC:3.6.1.11 3.6.1.40]
CFBS_1080  hypothetical protein [KO:K01524] [EC:3.6.1.11 3.6.1.40]
CFBS_1345  putative adenylate cyclase [KO:K01768] [EC:4.6.1.1]
CFBS_1714  cya; membrane-anchored adenylyl cyclase Cya [KO:K01768] [EC:4.6.1.1]
CFBS_3862  putative adenylate cyclase [KO:K01768] [EC:4.6.1.1]
CFBS_0373  purA; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
CFBS_2331  cbhK; carbohydrate kinase CbhK [KO:K00856] [EC:2.7.1.20]
CFBS_3506  add; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
CFBS_0769  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
CFBS_1075  mazG; nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
CFBS_0846  hypothetical protein [KO:K03651] [EC:3.1.4.53]
CFBS_2765  hypothetical protein [KO:K19710] [EC:2.7.7.53]
CFBS_1367  cysN; bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein [KO:K00955] [EC:2.7.7.4 2.7.1.25]
CFBS_1366  cysD; sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
CFBS_1942  ureC; urease subunit alpha [KO:K01428] [EC:3.5.1.5]
CFBS_1941  ureB; urease subunit beta [KO:K01429] [EC:3.5.1.5]
CFBS_1940  ureA; urease subunit gamma [KO:K01430] [EC:3.5.1.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mtur00030  Pentose phosphate pathway
mtur00220  Arginine biosynthesis
mtur00250  Alanine, aspartate and glutamate metabolism
mtur00260  Glycine, serine and threonine metabolism
mtur00340  Histidine metabolism
mtur00630  Glyoxylate and dicarboxylate metabolism
mtur00730  Thiamine metabolism
mtur00740  Riboflavin metabolism
mtur00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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