KEGG   PATHWAY: mtuu00230
Entry
mtuu00230                   Pathway                                
Name
Purine metabolism - Mycobacterium tuberculosis BT2
Class
Metabolism; Nucleotide metabolism
Pathway map
mtuu00230  Purine metabolism
mtuu00230

Module
mtuu_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:mtuu00230]
mtuu_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:mtuu00230]
mtuu_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:mtuu00230]
mtuu_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:mtuu00230]
mtuu_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:mtuu00230]
Other DBs
GO: 0006163 0042278
Organism
Mycobacterium tuberculosis BT2 [GN:mtuu]
Gene
HKBT2_3228  pgmA; phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
HKBT2_1074  prsA; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
HKBT2_0850  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
HKBT2_0812  purD; phosphoribosylamine-glycine ligase [KO:K01945] [EC:6.3.4.13]
HKBT2_1007  purN; 5-phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
HKBT2_0404  purT; phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
HKBT2_0845  purL; phosphoribosylformylglycinamidine synthase II [KO:K23269] [EC:6.3.5.3]
HKBT2_0829  hypothetical protein [KO:K23264] [EC:6.3.5.3]
HKBT2_0830  purG; phosphoribosylformylglycinamidine synthase I [KO:K23265] [EC:6.3.5.3 3.5.1.2]
HKBT2_0851  purM; phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
HKBT2_3462  purK; phosphoribosylaminoimidazole carboxylase ATPase subunit [KO:K01589] [EC:6.3.4.18]
HKBT2_3460  purE; phosphoribosylaminoimidazole carboxylase catalytic subunit [KO:K01588] [EC:5.4.99.18]
HKBT2_0820  purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
HKBT2_0817  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
HKBT2_1008  purH; bifunctional purine biosynthesis protein [KO:K00602] [EC:2.1.2.3 3.5.4.10]
HKBT2_2729  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
HKBT2_3492  deoD; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
HKBT2_2271  yfiH; yfiH [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
HKBT2_3590  iunH; inosine-uridine preferring nucleoside hydrolase [KO:K01239] [EC:3.2.2.1]
HKBT2_3833  hpt; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
HKBT2_3608  guaB3; inosine 5-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
HKBT2_3609  guaB2; inosine 5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
HKBT2_2587  ndk; nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
HKBT2_1431  putative deoxyribonucleotide triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
HKBT2_3594  guaA; GMP synthase [KO:K01951] [EC:6.3.5.2]
HKBT2_1940  guaB1; inosine 5-monophosphate dehydrogenase [KO:K26110] [EC:1.7.1.7]
HKBT2_1486  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
HKBT2_3211  nrdE; ribonucleotide-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
HKBT2_0594  putative ribonucleoside-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
HKBT2_3208  nrdF2; ribonucleotide-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
HKBT2_0249  nrdB; ribonucleoside-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
HKBT2_2084  nrdF1; ribonucleotide-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
HKBT2_2475  dgt; deoxyguanosinetriphosphate triphosphohydrolase-like protein [KO:K01129] [EC:3.1.5.1]
HKBT2_2728  relA; GTP pyrophosphokinase RelA [KO:K01139] [EC:2.7.6.5 3.1.7.2]
HKBT2_1083  hypothetical protein [KO:K01524] [EC:3.6.1.11 3.6.1.40]
HKBT2_0517  hypothetical protein [KO:K01524] [EC:3.6.1.11 3.6.1.40]
HKBT2_1349  putative adenylate cyclase [KO:K01768] [EC:4.6.1.1]
HKBT2_1721  cya; membrane-anchored adenylyl cyclase Cya [KO:K01768] [EC:4.6.1.1]
HKBT2_3855  putative adenylate cyclase [KO:K01768] [EC:4.6.1.1]
HKBT2_0373  purA; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
HKBT2_2324  cbhK; carbohydrate kinase CbhK [KO:K00856] [EC:2.7.1.20]
HKBT2_3500  add; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
HKBT2_0770  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
HKBT2_1078  mazG; nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
HKBT2_0847  hypothetical protein [KO:K03651] [EC:3.1.4.53]
HKBT2_2759  hypothetical protein [KO:K19710] [EC:2.7.7.53]
HKBT2_1372  cysN; bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein [KO:K00955] [EC:2.7.7.4 2.7.1.25]
HKBT2_1371  cysD; sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
HKBT2_1947  ureC; urease subunit alpha [KO:K01428] [EC:3.5.1.5]
HKBT2_1946  ureB; urease subunit beta [KO:K01429] [EC:3.5.1.5]
HKBT2_1945  ureA; urease subunit gamma [KO:K01430] [EC:3.5.1.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mtuu00030  Pentose phosphate pathway
mtuu00220  Arginine biosynthesis
mtuu00250  Alanine, aspartate and glutamate metabolism
mtuu00260  Glycine, serine and threonine metabolism
mtuu00340  Histidine metabolism
mtuu00630  Glyoxylate and dicarboxylate metabolism
mtuu00730  Thiamine metabolism
mtuu00740  Riboflavin metabolism
mtuu00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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