KEGG   PATHWAY: mtz00630
Entry
mtz00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Mycobacterium tuberculosis KZN 605
Class
Metabolism; Carbohydrate metabolism
Pathway map
mtz00630  Glyoxylate and dicarboxylate metabolism
mtz00630

Module
mtz_M00012  Glyoxylate cycle [PATH:mtz00630]
mtz_M00621  Glycine cleavage system [PATH:mtz00630]
mtz_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:mtz00630]
Other DBs
GO: 0046487 0043648
Organism
Mycobacterium tuberculosis KZN 605 [GN:mtz]
Gene
TBXG_004002  isocitrate lyase aceAb [KO:K01637] [EC:4.1.3.1 4.1.3.30]
TBXG_004003  isocitrate lyase aceAa [KO:K01637] [EC:4.1.3.1 4.1.3.30]
TBXG_000467  isocitrate lyase icl [KO:K01637] [EC:4.1.3.1 4.1.3.30]
TBXG_003680  acetyl-CoA synthetase acs [KO:K01895] [EC:6.2.1.1]
TBXG_002139  malate synthase G glcB [KO:K01638] [EC:2.3.3.9]
TBXG_002721  malate dehydrogenase mdh [KO:K00024] [EC:1.1.1.37]
TBXG_003078  citrate synthase II citA [KO:K01647] [EC:2.3.3.1]
TBXG_003071  citrate synthase I gltA2 [KO:K01647] [EC:2.3.3.1]
TBXG_002832  citrate synthase I gltA1 [KO:K01659] [EC:2.3.3.5]
TBXG_002485  iron-regulated aconitate hydratase acn [KO:K27802] [EC:4.2.1.3 4.2.1.99]
TBXG_000246  acetyl-CoA acyltransferase fadA2 [KO:K00626] [EC:2.3.1.9]
TBXG_002109  hypothetical protein [KO:K00626] [EC:2.3.1.9]
TBXG_003110  acyl-CoA thiolase fadA [KO:K00626] [EC:2.3.1.9]
TBXG_003054  lipid carrier protein or keto acyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
TBXG_003561  acetyl-CoA acetyltransferase fadA5 [KO:K00626] [EC:2.3.1.9]
TBXG_003571  acetyl-CoA acetyltransferase fadA6 [KO:K00626] [EC:2.3.1.9]
TBXG_002635  acetyl-CoA acetyltransferase fadA4 [KO:K00626] [EC:2.3.1.9]
TBXG_002893  beta-ketoacyl CoA thiolase fadA3 [KO:K00626] [EC:2.3.1.9]
TBXG_003538  lipid carrier protein or keto acyl-CoA thiolase ltp3 [KO:K00626] [EC:2.3.1.9]
TBXG_002637  hypothetical protein [KO:K05606] [EC:5.1.99.1]
TBXG_003313  bifunctional acetyl-/propionyl-coenzyme A carboxylase subunit alpha accA3 [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]
TBXG_003308  propionyl-CoA carboxylase subunit beta 5 accD5 [KO:K27094] [EC:6.4.1.3 6.4.1.- 2.1.3.15]
TBXG_003309  hypothetical protein [KO:K27095]
TBXG_001715  acetyl/propionyl-CoA carboxylase beta subunit accD6 [KO:K18472] [EC:6.4.1.2 6.4.1.3 2.1.3.15]
TBXG_002466  methylmalonyl-CoA mutase large subunit mutB [KO:K01847] [EC:5.4.99.2]
TBXG_002467  methylmalonyl-CoA mutase small subunit mutA [KO:K01847] [EC:5.4.99.2]
TBXG_001687  dehydrogenase [KO:K00104] [EC:1.1.99.14]
TBXG_002704  oxidoreductase [KO:K00104] [EC:1.1.99.14]
TBXG_001729  hypothetical protein [KO:K01091] [EC:3.1.3.18]
TBXG_002098  glutamine synthetase glnA3 [KO:K01915] [EC:6.3.1.2]
TBXG_001740  glutamine synthetase glnA2 [KO:K01915] [EC:6.3.1.2]
TBXG_001742  glutamine synthetase glnA1 [KO:K01915] [EC:6.3.1.2]
TBXG_001100  glutamine synthetase glnA4 [KO:K01915] [EC:6.3.1.2]
TBXG_000070  serine hydroxymethyltransferase 2 glyA2 [KO:K00600] [EC:2.1.2.1]
TBXG_002871  serine hydroxymethyltransferase 1 glyA1 [KO:K00600] [EC:2.1.2.1]
TBXG_002145  glycine dehydrogenase gcvB [KO:K00281] [EC:1.4.4.2]
TBXG_001752  aminomethyltransferase gcvT [KO:K00605] [EC:2.1.2.10]
TBXG_000462  dihydrolipoamide dehydrogenase lpd [KO:K00382] [EC:1.8.1.4]
TBXG_002150  glycine cleavage system H protein gcvH [KO:K02437]
TBXG_001758  hypothetical protein [KO:K00865] [EC:2.7.1.165]
TBXG_002713  2-oxoglutarate dehydrogenase sucA [KO:K01616] [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
TBXG_000997  formyltetrahydrofolate deformylase purU [KO:K01433] [EC:3.5.1.10]
TBXG_000119  oxalyl-CoA decarboxylase oxcA [KO:K01577] [EC:4.1.1.8]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
mtz00010  Glycolysis / Gluconeogenesis
mtz00020  Citrate cycle (TCA cycle)
mtz00030  Pentose phosphate pathway
mtz00053  Ascorbate and aldarate metabolism
mtz00071  Fatty acid degradation
mtz00230  Purine metabolism
mtz00250  Alanine, aspartate and glutamate metabolism
mtz00260  Glycine, serine and threonine metabolism
mtz00620  Pyruvate metabolism
mtz00710  Carbon fixation by Calvin cycle
mtz00750  Vitamin B6 metabolism
mtz00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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