KEGG   PATHWAY: nasi03013
Entry
nasi03013                   Pathway                                
Name
Nucleocytoplasmic transport - Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
nasi03013  Nucleocytoplasmic transport
nasi03013

Other DBs
GO: 0050658
Organism
Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise) [GN:nasi]
Gene
112394255  AAAS; aladin [KO:K14320]
112395346  NUPL2; nucleoporin-like protein 2 [KO:K14321]
112411424  GLE1; nucleoporin GLE1 [KO:K18723]
112393354  DDX19A; ATP-dependent RNA helicase DDX19A [KO:K18655] [EC:5.6.2.7]
112393355  ATP-dependent RNA helicase DDX19B-like isoform X1 [KO:K18655] [EC:5.6.2.7]
112403029  RAE1; mRNA export factor [KO:K14298]
112390735  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
112411206  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
112392527  NUP88; nuclear pore complex protein Nup88 [KO:K14318]
112408377  E3 SUMO-protein ligase RanBP2-like isoform X1 [KO:K12172] [EC:2.3.2.-]
112394694  RANGAP1; ran GTPase-activating protein 1 [KO:K14319]
112409379  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
112396080  small ubiquitin-related modifier 2-like [KO:K12160]
112402711  small ubiquitin-related modifier 2-like isoform X1 [KO:K12160]
112410175  SUMO2; small ubiquitin-related modifier 2 [KO:K12160]
112397112  small ubiquitin-related modifier 1 [KO:K12160]
112405514  small ubiquitin-related modifier 2-like [KO:K12160]
112407882  SUMO1; small ubiquitin-related modifier 1 [KO:K12160]
112394878  small ubiquitin-related modifier 1-like [KO:K12160]
112408648  SUMO3; LOW QUALITY PROTEIN: small ubiquitin-related modifier 3 [KO:K12160]
112408663  small ubiquitin-related modifier 2-like [KO:K12160]
112391341  small ubiquitin-related modifier 2 [KO:K12160]
112402424  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
112410434  NUP85; nuclear pore complex protein Nup85 [KO:K14304]
112396449  SEC13; protein SEC13 homolog [KO:K14004]
112394333  NUP107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
112413600  NUP133; nuclear pore complex protein Nup133 isoform X1 [KO:K14300]
112412181  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
112401571  NUP43; nucleoporin Nup43 isoform X1 [KO:K14305]
112391079  NUP37; nucleoporin Nup37 isoform X1 [KO:K14302]
112395693  AHCTF1; protein ELYS isoform X1 [KO:K25129]
112395080  NUP62CL; nucleoporin-62 C-terminal-like protein [KO:K14306]
112415582  NUP62; nuclear pore glycoprotein p62 isoform X1 [KO:K14306]
112403474  NUP58; nucleoporin p58/p45 [KO:K14307]
112405688  NUP54; nucleoporin p54 [KO:K14308]
112394977  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
112411436  NUP188; nucleoporin NUP188 homolog isoform X1 [KO:K14311]
112406015  NUP155; nuclear pore complex protein Nup155 [KO:K14312]
112401283  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
112414325  NUP35; nucleoporin NUP35 isoform X1 [KO:K14313]
112395905  NDC1; nucleoporin NDC1 [KO:K14315]
112411997  NUP210; nuclear pore membrane glycoprotein 210 [KO:K14314]
112401746  NUP210L; nuclear pore membrane glycoprotein 210-like [KO:K14314]
112404121  POM121L2; LOW QUALITY PROTEIN: POM121-like protein 2 [KO:K14316]
112401111  POM121; nuclear envelope pore membrane protein POM 121 [KO:K14316]
112390660  TMEM33; transmembrane protein 33 [KO:K20724]
112403492  TPR; nucleoprotein TPR isoform X1 [KO:K09291]
112394649  NUP50; nuclear pore complex protein Nup50 isoform X1 [KO:K14295]
112412525  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
112415284  SENP2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
112416035  KPNA1; importin subunit alpha-5 [KO:K23940]
112410538  KPNA2; importin subunit alpha-1 [KO:K15043]
112399938  KPNA7; importin subunit alpha-8 [KO:K15043]
112406242  KPNA4; importin subunit alpha-3 [KO:K23583]
112406569  KPNA3; importin subunit alpha-4 [KO:K23583]
112407403  KPNA5; importin subunit alpha-6 [KO:K15042]
112414299  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
112398166  KPNB1; importin subunit beta-1 [KO:K14293]
112391412  TNPO1; transportin-1 isoform X1 [KO:K18752]
112414761  TNPO2; transportin-2 isoform X1 [KO:K18727]
112411528  TNPO3; transportin-3 isoform X1 [KO:K15436]
112404989  IPO4; importin-4 isoform X1 [KO:K20221]
112396281  IPO5; importin-5 [KO:K20222]
112414186  LOW QUALITY PROTEIN: importin-7-like [KO:K20223]
112407649  IPO7; importin-7 [KO:K20223]
112401059  IPO8; importin-8 [KO:K18755]
112402635  IPO9; importin-9 [KO:K20224]
112413402  IPO11; importin-11 isoform X1 [KO:K25201]
112410001  IPO13; importin-13 [KO:K25202]
112410964  SNUPN; snurportin-1 [KO:K13151]
112404883  XPO1; exportin-1 [KO:K14290]
112403018  CSE1L; exportin-2 isoform X1 [KO:K18423]
112394170  XPOT; exportin-T isoform X1 [KO:K14288]
112403706  XPO4; exportin-4 isoform X1 [KO:K25203]
112413851  XPO5; exportin-5 isoform X1 [KO:K14289]
112399198  XPO6; exportin-6 isoform X1 [KO:K25204]
112401431  XPO7; exportin-7 isoform X1 [KO:K18460]
112405141  RANBP17; ran-binding protein 17 isoform X1 [KO:K24115]
112407951  LOW QUALITY PROTEIN: GTP-binding nuclear protein Ran-like [KO:K07936]
112408839  RAN; LOW QUALITY PROTEIN: GTP-binding nuclear protein Ran [KO:K07936]
112391136  GTP-binding nuclear protein Ran-like [KO:K07936]
112402944  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
112403334  LOW QUALITY PROTEIN: elongation factor 1-alpha 1-like [KO:K03231]
112413879  LOW QUALITY PROTEIN: putative elongation factor 1-alpha-like 3 [KO:K03231]
112390794  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
112407779  PHAX; phosphorylated adapter RNA export protein [KO:K14291]
112392610  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
112404251  NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
112412131  NMD3; 60S ribosomal export protein NMD3 isoform X1 [KO:K07562]
112391358  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
112395870  MAGOH; protein mago nashi homolog [KO:K12877]
112391814  MAGOHB; protein mago nashi homolog 2 isoform X1 [KO:K12877]
112399226  CASC3; protein CASC3 [KO:K14323]
112410468  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
112397490  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
112405133  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
112409403  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
112397693  RNA-binding protein with serine-rich domain 1-like [KO:K14325]
112411127  PNN; pinin [KO:K13114]
112410196  ALYREF; THO complex subunit 4 [KO:K12881]
112414816  UPF1; regulator of nonsense transcripts 1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
112392438  UPF2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
112404042  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
112404602  UPF3A; regulator of nonsense transcripts 3A [KO:K14328]
112402107  NXF1; nuclear RNA export factor 1 [KO:K14284]
112404600  nuclear RNA export factor 2-like [KO:K14284]
112411694  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
112400918  NXF3; nuclear RNA export factor 3 [KO:K14284]
112402105  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
112403371  NXT1; NTF2-related export protein 1 isoform X1 [KO:K14285]
112395394  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
112414260  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
112393943  PYM1; partner of Y14 and mago [KO:K14294]
112408299  THOC1; THO complex subunit 1 [KO:K12878]
112401042  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
112415127  THOC5; THO complex subunit 5 homolog [KO:K13174]
112409549  THOC6; THO complex subunit 6 homolog isoform X1 [KO:K13175]
112400620  THOC7; THO complex subunit 7 homolog [KO:K13176]
112397875  THOC3; THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
nasi03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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