KEGG   PATHWAY: ncs00260
Entry
ncs00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Naumovozyma castellii
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ncs00260  Glycine, serine and threonine metabolism
ncs00260

Module
ncs_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ncs00260]
ncs_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ncs00260]
ncs_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:ncs00260]
ncs_M00621  Glycine cleavage system [PATH:ncs00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Naumovozyma castellii [GN:ncs]
Gene
NCAS_0E03110  NCAS0E03110; hypothetical protein [KO:K00928] [EC:2.7.2.4]
NCAS_0B03400  NCAS0B03400; hypothetical protein [KO:K00133] [EC:1.2.1.11]
NCAS_0A06370  NCAS0A06370; hypothetical protein [KO:K00003] [EC:1.1.1.3]
NCAS_0A06740  NCAS0A06740; hypothetical protein [KO:K00872] [EC:2.7.1.39]
NCAS_0D04460  NCAS0D04460; hypothetical protein [KO:K01733] [EC:4.2.3.1]
NCAS_0A13030  NCAS0A13030; hypothetical protein [KO:K01620] [EC:4.1.2.48]
NCAS_0C03800  NCAS0C03800; hypothetical protein [KO:K00600] [EC:2.1.2.1]
NCAS_0B07350  NCAS0B07350; hypothetical protein [KO:K00600] [EC:2.1.2.1]
NCAS_0C03790  NCAS0C03790; hypothetical protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
NCAS_0F02370  NCAS0F02370; hypothetical protein [KO:K01834] [EC:5.4.2.11]
NCAS_0C03650  NCAS0C03650; hypothetical protein [KO:K01834] [EC:5.4.2.11]
NCAS_0A07300  NCAS0A07300; hypothetical protein [KO:K15918] [EC:2.7.1.31]
NCAS_0A13680  NCAS0A13680; hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
NCAS_0E03480  NCAS0E03480; hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
NCAS_0F00420  NCAS0F00420; hypothetical protein [KO:K00831] [EC:2.6.1.52]
NCAS_0A07340  NCAS0A07340; hypothetical protein [KO:K01079] [EC:3.1.3.3]
NCAS_0C00980  NCAS0C00980; hypothetical protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
NCAS_0B02680  NCAS0B02680; hypothetical protein [KO:K00643] [EC:2.3.1.37]
NCAS_0D03830  NCAS0D03830; hypothetical protein [KO:K00281] [EC:1.4.4.2]
NCAS_0A10410  NCAS0A10410; hypothetical protein [KO:K00605] [EC:2.1.2.10]
NCAS_0J00500  NCAS0J00500; hypothetical protein [KO:K00382] [EC:1.8.1.4]
NCAS_0A07530  NCAS0A07530; hypothetical protein [KO:K02437]
NCAS_0J00530  NCAS0J00530; hypothetical protein [KO:K00273] [EC:1.4.3.3]
NCAS_0F03670  NCAS0F03670; hypothetical protein [KO:K17103] [EC:2.7.8.8]
NCAS_0E00640  NCAS0E00640; hypothetical protein [KO:K17103] [EC:2.7.8.8]
NCAS_0C05620  NCAS0C05620; hypothetical protein [KO:K01697] [EC:4.2.1.22]
NCAS_0F01520  NCAS0F01520; hypothetical protein [KO:K01758] [EC:4.4.1.1]
NCAS_0A14230  NCAS0A14230; hypothetical protein [KO:K01754] [EC:4.3.1.19]
NCAS_0A15330  NCAS0A15330; hypothetical protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
NCAS_0B09130  NCAS0B09130; hypothetical protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
NCAS_0B05450  NCAS0B05450; hypothetical protein [KO:K20498] [EC:4.3.1.18]
NCAS_0C05520  NCAS0C05520; hypothetical protein [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ncs00010  Glycolysis / Gluconeogenesis
ncs00020  Citrate cycle (TCA cycle)
ncs00230  Purine metabolism
ncs00250  Alanine, aspartate and glutamate metabolism
ncs00270  Cysteine and methionine metabolism
ncs00290  Valine, leucine and isoleucine biosynthesis
ncs00300  Lysine biosynthesis
ncs00330  Arginine and proline metabolism
ncs00460  Cyanoamino acid metabolism
ncs00470  D-Amino acid metabolism
ncs00564  Glycerophospholipid metabolism
ncs00600  Sphingolipid metabolism
ncs00620  Pyruvate metabolism
ncs00630  Glyoxylate and dicarboxylate metabolism
ncs00640  Propanoate metabolism
ncs00680  Methane metabolism
ncs00860  Porphyrin metabolism
ncs00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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