KEGG   PATHWAY: nfi00260
Entry
nfi00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Aspergillus fischeri
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
nfi00260  Glycine, serine and threonine metabolism
nfi00260

Module
nfi_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:nfi00260]
nfi_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:nfi00260]
nfi_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:nfi00260]
nfi_M00621  Glycine cleavage system [PATH:nfi00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Aspergillus fischeri [GN:nfi]
Gene
NFIA_037460  aspartokinase [KO:K00928] [EC:2.7.2.4]
NFIA_070420  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
NFIA_065670  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
NFIA_037310  homoserine kinase [KO:K00872] [EC:2.7.1.39]
NFIA_068150  threonine synthase [KO:K01733] [EC:4.2.3.1]
NFIA_060300  l-allo-threonine aldolase [KO:K01620] [EC:4.1.2.48]
NFIA_090170  l-allo-threonine aldolase [KO:K01620] [EC:4.1.2.48]
NFIA_027830  threonine aldolase, putative [KO:K01620] [EC:4.1.2.48]
NFIA_083520  cytosolic hydroxymethyltransferase, putative [KO:K00600] [EC:2.1.2.1]
NFIA_067820  serine hydroxymethyltransferase, putative [KO:K00600] [EC:2.1.2.1]
NFIA_016140  aminotransferase, class V, putative [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
NFIA_074400  glycerate kinase family protein [KO:K00865] [EC:2.7.1.165]
NFIA_067840  phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [KO:K15633] [EC:5.4.2.12]
NFIA_029510  uridine/cytidine kinase, putative [KO:K15918] [EC:2.7.1.31]
NFIA_037560  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
NFIA_081250  d-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
NFIA_051530  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
NFIA_070710  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
NFIA_076040  oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
NFIA_036860  5-aminolevulinic acid synthase HemA [KO:K00643] [EC:2.3.1.37]
NFIA_001270  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
NFIA_062690  copper amine oxidase, putative [KO:K00276] [EC:1.4.3.21]
NFIA_012060  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
NFIA_025150  amine oxidase [KO:K00276] [EC:1.4.3.21]
NFIA_040640  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
NFIA_079900  peroxisomal copper amine oxidase [KO:K00276] [EC:1.4.3.21]
NFIA_029640  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
NFIA_014860  glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
NFIA_034470  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
NFIA_013440  glycine cleavage system H protein [KO:K02437]
NFIA_075980  D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
NFIA_004660  FAD dependent oxidoreductase, putative [KO:K00273] [EC:1.4.3.3]
NFIA_073030  FAD dependent oxidoreductase superfamily [KO:K00273] [EC:1.4.3.3]
NFIA_102710  phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
NFIA_096790  betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
NFIA_099100  NAD dehydrogenase [KO:K00309] [EC:1.5.3.10]
NFIA_099070  sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
NFIA_067160  fructosyl amino acid oxidasesarcosine oxidase, putative [KO:K00306] [EC:1.5.3.1 1.5.3.7]
NFIA_023580  sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
NFIA_028080  conserved hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
NFIA_034400  fructosyl amine:oxygen oxidoreductase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
NFIA_083350  cystathionine beta-synthase, putative [KO:K01697] [EC:4.2.1.22]
NFIA_097070  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
NFIA_108060  threonine dehydratase, biosynthetic [KO:K01754] [EC:4.3.1.19]
NFIA_062780  Pyridoxal-phosphate dependent enzyme, putative [KO:K01754] [EC:4.3.1.19]
NFIA_018580  L-serine dehydratase, putative [KO:K17989] [EC:4.3.1.17 4.3.1.19]
NFIA_108360  l-serine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
NFIA_029690  conserved hypothetical protein [KO:K20498] [EC:4.3.1.18]
NFIA_102480  conserved hypothetical protein [KO:K20498] [EC:4.3.1.18]
NFIA_088420  bifunctional tryptophan synthase TRPB [KO:K01694] [EC:4.2.1.20]
NFIA_049580  tryptophan synthase beta chain [KO:K01694] [EC:4.2.1.20]
NFIA_059480  tryptophan synthase [KO:K01694] [EC:4.2.1.20]
NFIA_055160  tryptophan synthase beta chain [KO:K06001] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
nfi00010  Glycolysis / Gluconeogenesis
nfi00020  Citrate cycle (TCA cycle)
nfi00230  Purine metabolism
nfi00250  Alanine, aspartate and glutamate metabolism
nfi00270  Cysteine and methionine metabolism
nfi00290  Valine, leucine and isoleucine biosynthesis
nfi00300  Lysine biosynthesis
nfi00330  Arginine and proline metabolism
nfi00460  Cyanoamino acid metabolism
nfi00470  D-Amino acid metabolism
nfi00564  Glycerophospholipid metabolism
nfi00600  Sphingolipid metabolism
nfi00620  Pyruvate metabolism
nfi00630  Glyoxylate and dicarboxylate metabolism
nfi00640  Propanoate metabolism
nfi00680  Methane metabolism
nfi00860  Porphyrin metabolism
nfi00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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