KEGG   PATHWAY: oct00260
Entry
oct00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Octadecabacter sp. SW4
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
oct00260  Glycine, serine and threonine metabolism
oct00260

Module
oct_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:oct00260]
oct_M00555  Betaine biosynthesis, choline => betaine [PATH:oct00260]
oct_M00621  Glycine cleavage system [PATH:oct00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Octadecabacter sp. SW4 [GN:oct]
Gene
FTO60_11860  aspartate kinase [KO:K00928] [EC:2.7.2.4]
FTO60_00470  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
FTO60_04375  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
FTO60_11940  threonine synthase [KO:K01733] [EC:4.2.3.1]
FTO60_13175  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
FTO60_11895  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
FTO60_03775  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
FTO60_11595  alanine--glyoxylate aminotransferase family protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
FTO60_12285  aminotransferase class V-fold PLP-dependent enzyme [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
FTO60_03270  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
FTO60_05900  DUF4147 domain-containing protein [KO:K11529] [EC:2.7.1.165]
FTO60_00335  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
FTO60_00160  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FTO60_01420  D-2-hydroxyacid dehydrogenase family protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FTO60_03705  C-terminal binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FTO60_00165  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
FTO60_00175  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
FTO60_00120  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
FTO60_00125  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
FTO60_08780  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
FTO60_10275  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
FTO60_04305  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
FTO60_04320  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
FTO60_04310  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
FTO60_08660  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
FTO60_02600  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
FTO60_02930  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
FTO60_04315  gcvH; glycine cleavage system protein GcvH [KO:K02437]
FTO60_02795  M24 family metallopeptidase [KO:K08688] [EC:3.5.3.3]
FTO60_04470  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
FTO60_04465  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
FTO60_13430  FAD-dependent oxidoreductase [KO:K00315] [EC:1.5.8.4]
FTO60_15110  FAD-dependent oxidoreductase [KO:K00315] [EC:1.5.8.4]
FTO60_12415  FAD-dependent oxidoreductase [KO:K00315] [EC:1.5.8.4]
FTO60_03970  FAD-dependent oxidoreductase [KO:K00315] [EC:1.5.8.4]
FTO60_07420  FAD-dependent oxidoreductase [KO:K00315] [EC:1.5.8.4]
FTO60_07425  FAD-dependent oxidoreductase [KO:K00315] [EC:1.5.8.4]
FTO60_06255  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
FTO60_06275  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
FTO60_06265  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
FTO60_04955  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
FTO60_03615  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
FTO60_12550  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
FTO60_12595  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
FTO60_07550  M24 family metallopeptidase [KO:K15783] [EC:3.5.4.44]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
oct00010  Glycolysis / Gluconeogenesis
oct00020  Citrate cycle (TCA cycle)
oct00230  Purine metabolism
oct00250  Alanine, aspartate and glutamate metabolism
oct00270  Cysteine and methionine metabolism
oct00290  Valine, leucine and isoleucine biosynthesis
oct00300  Lysine biosynthesis
oct00330  Arginine and proline metabolism
oct00460  Cyanoamino acid metabolism
oct00470  D-Amino acid metabolism
oct00564  Glycerophospholipid metabolism
oct00600  Sphingolipid metabolism
oct00620  Pyruvate metabolism
oct00630  Glyoxylate and dicarboxylate metabolism
oct00640  Propanoate metabolism
oct00680  Methane metabolism
oct00860  Porphyrin metabolism
oct00920  Sulfur metabolism
KO pathway
ko00260   
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