KEGG   PATHWAY: oda04390
Entry
oda04390                    Pathway                                
Name
Hippo signaling pathway - Oryx dammah (scimitar-horned oryx)
Description
Hippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor Salvador and LATS1 and LATS2. In response to high cell densities, activated LATS1/2 phosphorylates the transcriptional coactivators YAP and TAZ, promoting its cytoplasmic localization, leading to cell apoptosis and restricting organ size overgrowth. When the Hippo pathway is inactivated at low cell density, YAP/TAZ translocates into the nucleus to bind to the transcription enhancer factor (TEAD/TEF) family of transcriptional factors to promote cell growth and proliferation. YAP/TAZ also interacts with other transcriptional factors or signaling molecules, by which Hippo pathway-mediated processes are interconnected with those of other key signaling cascades, such as those mediated by TGF-beta and Wnt growth factors.
Class
Environmental Information Processing; Signal transduction
Pathway map
oda04390  Hippo signaling pathway
oda04390

Other DBs
GO: 0035329
Organism
Oryx dammah (scimitar-horned oryx) [GN:oda]
Gene
120880424  CRB1; protein crumbs homolog 1 [KO:K16681]
120851976  CRB2; protein crumbs homolog 2 [KO:K16681]
120869241  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
120880964  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
120869088  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
120872726  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
120880614  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
120869542  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
120857064  PATJ; inaD-like protein isoform X1 [KO:K06092]
120852799  PALS1; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
120881406  AMOT; angiomotin isoform X1 [KO:K16819]
120876086  YAP1; transcriptional coactivator YAP1 [KO:K16687]
120858517  WWTR1; WW domain-containing transcription regulator protein 1 [KO:K16820]
120872702  CDH1; cadherin-1 [KO:K05689]
120868146  LIMD1; LIM domain-containing protein 1 [KO:K16682]
120853423  AJUBA; LIM domain-containing protein ajuba isoform X1 [KO:K16682]
120872627  Wilms tumor protein 1-interacting protein [KO:K16682]
120871225  NF2; merlin isoform X1 [KO:K16684]
120863314  WWC1; protein KIBRA [KO:K16685]
120862691  FRMD1; FERM domain-containing protein 1 [KO:K16821]
120853108  FRMD6; FERM domain-containing protein 6 isoform X1 [KO:K16822]
120853119  SAV1; protein salvador homolog 1 [KO:K16686]
120878440  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
120861428  RASSF6; ras association domain-containing protein 6 isoform X1 [KO:K09854]
120868307  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
120863659  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
120865628  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
120876226  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
120859757  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
120871966  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
120861553  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
120863494  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
120865981  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
120882961  LATS2; serine/threonine-protein kinase LATS2 isoform X1 [KO:K08791] [EC:2.7.11.1]
120862601  LATS1; serine/threonine-protein kinase LATS1 [KO:K08791] [EC:2.7.11.1]
120861413  MOB1B; MOB kinase activator 1B isoform X1 [KO:K06685]
120851257  MOB1A; MOB kinase activator 1A [KO:K06685]
120851530  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
120874772  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
120871062  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
120880359  TP53BP2; apoptosis-stimulating of p53 protein 2 isoform X1 [KO:K16823]
120867392  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
120866728  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
120878754  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
120870023  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
120874251  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
120882014  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
120866078  DLG4; disks large homolog 4 isoform X1 [KO:K11828]
120865252  DLG5; disks large homolog 5 isoform X1 [KO:K24050]
120866899  CSNK1D; casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
120857637  casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
120879679  FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
120873542  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
120880666  TP73; tumor protein p73 isoform X1 [KO:K10148]
120872234  BBC3; bcl-2-binding component 3 [KO:K10132]
120876441  TEAD1; transcriptional enhancer factor TEF-1 isoform X1 [KO:K09448]
120870221  TEAD3; transcriptional enhancer factor TEF-5 isoform X1 [KO:K09448]
120872144  TEAD2; LOW QUALITY PROTEIN: transcriptional enhancer factor TEF-4 [KO:K09448]
120857865  TEAD4; transcriptional enhancer factor TEF-3 isoform X1 [KO:K09448]
120863025  CCN2; CCN family member 2 [KO:K06827]
120854710  GLI2; zinc finger protein GLI2 [KO:K16798]
120861445  AREG; amphiregulin [KO:K09782]
120866827  BIRC5; baculoviral IAP repeat-containing protein 5 isoform X1 [KO:K08731]
120861426  alpha-fetoprotein [KO:K16144]
120861610  LOW QUALITY PROTEIN: alpha-fetoprotein-like [KO:K16144]
120881345  ITGB2; integrin beta-2 [KO:K06464]
120863516  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
120872413  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
120880130  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
120852691  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
120862774  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
120867879  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
120881001  SMAD7; mothers against decapentaplegic homolog 7 isoform X1 [KO:K19631]
120881010  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
120852520  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
120860896  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
120880976  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
120879013  SERPINE1; plasminogen activator inhibitor 1 [KO:K03982]
120868917  BMP2; bone morphogenetic protein 2 [KO:K21283]
120852924  BMP4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
120869881  BMP5; bone morphogenetic protein 5 [KO:K04663]
120869932  BMP6; bone morphogenetic protein 6 isoform X1 [KO:K16620]
120869359  BMP7; bone morphogenetic protein 7 isoform X1 [KO:K16621]
120861077  bone morphogenetic protein 8A-like [KO:K16622]
120856368  bone morphogenetic protein 8B [KO:K16622]
120868670  GDF5; growth/differentiation factor 5 [KO:K04664]
120878463  GDF6; growth/differentiation factor 6 [KO:K20012]
120851903  GDF7; growth/differentiation factor 7 [KO:K20013]
120864766  AMH; muellerian-inhibiting factor [KO:K04665]
120865160  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
120861921  BMPR1B; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
120854606  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
120870885  SMAD1; mothers against decapentaplegic homolog 1 isoform X1 [KO:K04676]
120868764  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
120851898  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
120861282  proto-oncogene Wnt-1 [KO:K03209]
120858193  proto-oncogene Wnt-1 [KO:K03209]
120878206  WNT2; protein Wnt-2 [KO:K00182]
120856080  WNT2B; protein Wnt-2b [KO:K00182]
120864656  WNT3A; protein Wnt-3a [KO:K00312]
120866987  WNT3; proto-oncogene Wnt-3 [KO:K00312]
120854508  WNT4; protein Wnt-4 [KO:K00408]
120867939  WNT5A; protein Wnt-5a [KO:K00444]
120857844  WNT5B; protein Wnt-5b [KO:K00444]
120854363  WNT6; protein Wnt-6 [KO:K00445]
120868443  WNT7A; protein Wnt-7a [KO:K00572]
120858471  WNT7B; protein Wnt-7b [KO:K00572]
120863617  WNT8A; protein Wnt-8a [KO:K00714]
120873949  WNT8B; protein Wnt-8b [KO:K00714]
120864325  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
120866573  WNT9B; protein Wnt-9b [KO:K01064]
120861284  protein Wnt-10b-like [KO:K01357]
120854362  WNT10A; protein Wnt-10a [KO:K01357]
120858215  protein Wnt-10b [KO:K01357]
120876802  WNT11; protein Wnt-11 [KO:K01384]
120877289  WNT16; protein Wnt-16 [KO:K01558]
120877844  FZD1; frizzled-1 [KO:K02432]
120854611  FZD7; frizzled-7 [KO:K02432]
120867021  FZD2; frizzled-2 [KO:K02235]
120860622  FZD3; frizzled-3 [KO:K02329]
120874234  FZD4; frizzled-4 [KO:K02354]
120860124  frizzled-8 [KO:K02375]
120854561  FZD5; frizzled-5 [KO:K02375]
120878963  FZD6; frizzled-6 isoform X1 [KO:K02376]
120878550  FZD9; frizzled-9 [KO:K02842]
120871557  FZD10; frizzled-10 [KO:K02842]
120880612  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
120871944  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
120866079  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
120878419  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
120851886  YWHAQ; 14-3-3 protein theta [KO:K16197]
120869555  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
120866234  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
120878832  YWHAG; 14-3-3 protein gamma [KO:K16198]
120871275  YWHAH; 14-3-3 protein eta isoform X1 [KO:K16198]
120871233  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
120867709  CTNNB1; catenin beta-1 [KO:K02105]
120852624  adenomatous polyposis coli protein isoform X1 [KO:K02085]
120861004  adenomatous polyposis coli protein isoform X1 [KO:K02085]
120863696  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
120854912  AXIN1; axin-1 isoform X1 [KO:K02157]
120866533  AXIN2; LOW QUALITY PROTEIN: axin-2 [KO:K04385]
120879240  NKD2; protein naked cuticle homolog 2 [KO:K03213]
120872809  NKD1; protein naked cuticle homolog 1 [KO:K03213]
120863661  TCF7; transcription factor 7 isoform X1 [KO:K02620]
120851515  TCF7L1; transcription factor 7-like 1 [KO:K04490]
120873902  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
120861741  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
120878883  MYC; myc proto-oncogene protein [KO:K04377]
120874144  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
120857878  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
120870130  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
120871592  SOX2; transcription factor SOX-2 [KO:K16796]
120878560  SNAI2; zinc finger protein SNAI2 [KO:K05706]
120876161  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
120876162  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
120856263  ACTB; actin, cytoplasmic 1 [KO:K05692]
120873725  actin, cytoplasmic 1-like [KO:K05692]
120866873  ACTG1; actin, cytoplasmic 2 [KO:K05692]
120860803  catenin alpha-2-like isoform X1 [KO:K05691]
120863599  CTNNA1; catenin alpha-1 [KO:K05691]
120865199  CTNNA3; catenin alpha-3 [KO:K05691]
120866501  LOW QUALITY PROTEIN: catenin alpha-1-like [KO:K05691]
120851300  catenin alpha-2 isoform X1 [KO:K05691]
Reference
PMID:22750148
  Authors
Schroeder MC, Halder G
  Title
Regulation of the Hippo pathway by cell architecture and mechanical signals.
  Journal
Semin Cell Dev Biol 23:803-11 (2012)
DOI:10.1016/j.semcdb.2012.06.001
Reference
PMID:21808241
  Authors
Zhao B, Tumaneng K, Guan KL
  Title
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal.
  Journal
Nat Cell Biol 13:877-83 (2011)
DOI:10.1038/ncb2303
Reference
PMID:21874053
  Authors
Mauviel A, Nallet-Staub F, Varelas X
  Title
Integrating developmental signals: a Hippo in the (path)way.
  Journal
Oncogene 31:1743-56 (2012)
DOI:10.1038/onc.2011.363
Reference
PMID:21084559
  Authors
Zhao B, Li L, Guan KL
  Title
Hippo signaling at a glance.
  Journal
J Cell Sci 123:4001-6 (2010)
DOI:10.1242/jcs.069070
Reference
PMID:20439427
  Authors
Zhao B, Li L, Lei Q, Guan KL
  Title
The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version.
  Journal
Genes Dev 24:862-74 (2010)
DOI:10.1101/gad.1909210
Reference
PMID:23034192
  Authors
Tremblay AM, Camargo FD
  Title
Hippo signaling in mammalian stem cells.
  Journal
Semin Cell Dev Biol 23:818-26 (2012)
DOI:10.1016/j.semcdb.2012.08.001
Reference
PMID:21138973
  Authors
Halder G, Johnson RL
  Title
Hippo signaling: growth control and beyond.
  Journal
Development 138:9-22 (2011)
DOI:10.1242/dev.045500
Reference
PMID:22658639
  Authors
Ramos A, Camargo FD
  Title
The Hippo signaling pathway and stem cell biology.
  Journal
Trends Cell Biol 22:339-46 (2012)
DOI:10.1016/j.tcb.2012.04.006
Reference
PMID:20951342
  Authors
Pan D
  Title
The hippo signaling pathway in development and cancer.
  Journal
Dev Cell 19:491-505 (2010)
DOI:10.1016/j.devcel.2010.09.011
Reference
PMID:21324984
  Authors
Bao Y, Hata Y, Ikeda M, Withanage K
  Title
Mammalian Hippo pathway: from development to cancer and beyond.
  Journal
J Biochem 149:361-79 (2011)
DOI:10.1093/jb/mvr021
Reference
PMID:18955139
  Authors
Zhao B, Lei QY, Guan KL
  Title
The Hippo-YAP pathway: new connections between regulation of organ size and cancer.
  Journal
Curr Opin Cell Biol 20:638-46 (2008)
DOI:10.1016/j.ceb.2008.10.001
Reference
PMID:20945341
  Authors
Chan SW, Lim CJ, Chen L, Chong YF, Huang C, Song H, Hong W
  Title
The Hippo pathway in biological control and cancer development.
  Journal
J Cell Physiol 226:928-39 (2011)
DOI:10.1002/jcp.22435
Reference
PMID:18328423
  Authors
Zeng Q, Hong W
  Title
The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals.
  Journal
Cancer Cell 13:188-92 (2008)
DOI:10.1016/j.ccr.2008.02.011
Reference
PMID:19846288
  Authors
Badouel C, Garg A, McNeill H
  Title
Herding Hippos: regulating growth in flies and man.
  Journal
Curr Opin Cell Biol 21:837-43 (2009)
DOI:10.1016/j.ceb.2009.09.010
Reference
PMID:17975546
  Authors
Buttitta LA, Edgar BA
  Title
How size is controlled: from Hippos to Yorkies.
  Journal
Nat Cell Biol 9:1225-7 (2007)
DOI:10.1038/ncb1107-1225
Reference
PMID:22683405
  Authors
Liu AM, Wong KF, Jiang X, Qiao Y, Luk JM
  Title
Regulators of mammalian Hippo pathway in cancer.
  Journal
Biochim Biophys Acta 1826:357-64 (2012)
DOI:10.1016/j.bbcan.2012.05.006
Reference
PMID:22830020
  Authors
Fausti F, Di Agostino S, Sacconi A, Strano S, Blandino G
  Title
Hippo and rassf1a Pathways: A Growing Affair.
  Journal
Mol Biol Int 2012:307628 (2012)
DOI:10.1155/2012/307628
Reference
PMID:22895435
  Authors
Halder G, Dupont S, Piccolo S
  Title
Transduction of mechanical and cytoskeletal cues by YAP and TAZ.
  Journal
Nat Rev Mol Cell Biol 13:591-600 (2012)
DOI:10.1038/nrm3416
Reference
PMID:22153608
  Authors
Varelas X, Wrana JL
  Title
Coordinating developmental signaling: novel roles for the Hippo pathway.
  Journal
Trends Cell Biol 22:88-96 (2012)
DOI:10.1016/j.tcb.2011.10.002
Reference
PMID:21376238
  Authors
Schlegelmilch K, Mohseni M, Kirak O, Pruszak J, Rodriguez JR, Zhou D, Kreger BT, Vasioukhin V, Avruch J, Brummelkamp TR, Camargo FD
  Title
Yap1 acts downstream of alpha-catenin to control epidermal proliferation.
  Journal
Cell 144:782-95 (2011)
DOI:10.1016/j.cell.2011.02.031
Related
pathway
oda04120  Ubiquitin mediated proteolysis
oda04310  Wnt signaling pathway
oda04350  TGF-beta signaling pathway
oda04520  Adherens junction
oda04530  Tight junction
KO pathway
ko04390   
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