Entry Name Type I diabetes mellitus - Oryx dammah (scimitar-horned oryx)
Description Type I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-presenting cell (APC), such as macrophages and dendritic cells, and presented in a complex with MHC-II molecules on the surface of the APC. Then immunogenic signals from APC activate CD4+ T cells, predominantly of the Th1 subset. Antigen-activated Th1 cells produce IL-2 and IFNgamma. They activate macrophages and cytotoxic CD8+ T cells, and these effector cells may kill islet beta-cells by one or both of two types of mechanisms: (1) direct interactions of antigen-specific cytotoxic T cells with a beta-cell autoantigen-MHC-I complex on the beta-cell, and (2) non-specific inflammatory mediators, such as free radicals/oxidants and cytokines (IL-1, TNFalpha, TNFbeta, IFNgamma).
Class Human Diseases; Endocrine and metabolic diseaseBRITE hierarchy
Pathway map Ortholog table Organism Oryx dammah (scimitar-horned oryx) [GN:
oda ]
Gene 120859624 BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06752 ]
120860003 BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06752 ]
120860570 SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752 ]
120869766 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
120869857 HLA class II histocompatibility antigen, DM alpha chain [KO:K06752 ]
120869858 HLA class II histocompatibility antigen, DO alpha chain-like [KO:K06752 ]
120869859 HLA class II histocompatibility antigen, DM beta chain [KO:K06752 ]
120869865 HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752 ]
120869866 rano class II histocompatibility antigen, A beta chain-like [KO:K06752 ]
120869867 SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752 ]
120869868 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
120870613 mamu class II histocompatibility antigen, DR alpha chain [KO:K06752 ]
120870614 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
120870615 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
120870618 boLa class II histocompatibility antigen, DQB*0101 beta chain isoform X1 [KO:K06752 ]
120870619 SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752 ]
120870620 HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752 ]
120870621 boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752 ]
120870982 CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413 ]
120881582 IL12A; LOW QUALITY PROTEIN: interleukin-12 subunit alpha [KO:K05406 ]
120859564 BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751 ]
120860566 BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751 ]
120870505 BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751 ]
120870511 BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751 ]
120870513 BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751 ]
120864527 H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751 ]
120880243 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
120873794 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
Compound Reference Authors Rabinovitch A, Suarez-Pinzon WL.
Title Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus.
Journal Reference Authors Cox NJ, Wapelhorst B, Morrison VA, Johnson L, Pinchuk L, Spielman RS, Todd JA, Concannon P
Title Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families.
Journal Reference Authors Davies JL, Kawaguchi Y, Bennett ST, Copeman JB, Cordell HJ, Pritchard LE, Reed PW, Gough SC, Jenkins SC, Palmer SM, et al.
Title A genome-wide search for human type 1 diabetes susceptibility genes.
Journal Reference Authors Fujisawa T, Ikegami H, Kawaguchi Y, Yamato E, Takekawa K, Nakagawa Y, Hamada Y, Ueda H, Shima K, Ogihara T.
Title Class I HLA is associated with age-at-onset of IDDM, while class II HLA confers susceptibility to IDDM.
Journal Reference Authors Jaeckel E, Klein L, Martin-Orozco N, von Boehmer H.
Title Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase.
Journal Reference Authors Nakayama M, Abiru N, Moriyama H, Babaya N, Liu E, Miao D, Yu L, Wegmann DR, Hutton JC, Elliott JF, Eisenbarth GS.
Title Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice.
Journal Reference Authors Kent SC, Chen Y, Bregoli L, Clemmings SM, Kenyon NS, Ricordi C, Hering BJ, Hafler DA.
Title Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope.
Journal Reference Authors Lieberman SM, DiLorenzo TP.
Title A comprehensive guide to antibody and T-cell responses in type 1 diabetes.
Journal Reference Authors Lord SJ, Rajotte RV, Korbutt GS, Bleackley RC.
Title Granzyme B: a natural born killer.
Journal Related oda04660 T cell receptor signaling pathway
KO pathway LinkDB All DBs
