KEGG PATHWAY: osn00260

PATHWAY: osn00260

Entry

osn00260                    Pathway

Name

Glycine, serine and threonine metabolism - Octopus sinensis (East Asian common octopus)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

osn00260

Glycine, serine and threonine metabolism

Module

osn_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:osn00260]

osn_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:osn00260]

osn_M00555

Betaine biosynthesis, choline => betaine [PATH:osn00260]

osn_M00621

Glycine cleavage system [PATH:osn00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Octopus sinensis (East Asian common octopus) [GN:osn]

Gene

115229460

probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]

115223084

probable low-specificity L-threonine aldolase 2 isoform X1 [KO:K01620] [EC:4.1.2.48]

115223085

probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]

115223320

probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]

115232446

serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]

115220966

serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]

115216620

glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]

115218137

glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]

115217818

glyoxylate reductase/hydroxypyruvate reductase-like isoform X1 [KO:K00049] [EC:1.1.1.79 1.1.1.81]

115209749

LOW QUALITY PROTEIN: glycerate kinase-like [KO:K11529] [EC:2.7.1.165]

115219769

probable phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]

115215657

D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

115219760

phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

115218046

phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]

115209329

2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]

115222132

L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]

115212743

5-aminolevulinate synthase, nonspecific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]

115214837

amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]

115229621

probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]

115214945

glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]

115210777

aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]

115212731

dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]

115214933

glycine cleavage system H protein [KO:K02437]

115215645

D-amino-acid oxidase-like isoform X1 [KO:K00273] [EC:1.4.3.3]

115216892

alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]

115221457

choline dehydrogenase, mitochondrial-like [KO:K00108] [EC:1.1.99.1]

115221581

uncharacterized protein LOC115221581 isoform X1 [KO:K00108] [EC:1.1.99.1]

115221456

choline dehydrogenase, mitochondrial-like [KO:K00108] [EC:1.1.99.1]

115218057

alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

115222981

betaine--homocysteine S-methyltransferase 1 isoform X2 [KO:K00544] [EC:2.1.1.5]

115223003

betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]

115222737

betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]

115224568

peroxisomal sarcosine oxidase-like isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]

115224569

peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]

115212101

cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]

115223921

cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]

115214097

L-threonine ammonia-lyase-like [KO:K01754] [EC:4.3.1.19]

115214098

L-threonine dehydratase catabolic TdcB-like [KO:K01754] [EC:4.3.1.19]

115216536

serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]

115214389

L-threonine ammonia-lyase-like [KO:K12235] [EC:5.1.1.18]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721