KEGG   PATHWAY: otm00260
Entry
otm00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Octadecabacter temperatus
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
otm00260  Glycine, serine and threonine metabolism
otm00260

Module
otm_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:otm00260]
otm_M00555  Betaine biosynthesis, choline => betaine [PATH:otm00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Octadecabacter temperatus [GN:otm]
Gene
OSB_07600  ask; Aspartokinase [KO:K00928] [EC:2.7.2.4]
OSB_00990  asd2; Aspartate-semialdehyde dehydrogenase 2 [KO:K00133] [EC:1.2.1.11]
OSB_22570  hom; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
OSB_07560  thrC; Threonine synthase [KO:K01733] [EC:4.2.3.1]
OSB_06580  ltaE; Low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
OSB_33080  Fluorothreonine transaldolase [KO:K00600] [EC:2.1.2.1]
OSB_23070  glyA1; Serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
OSB_08310  Soluble hydrogenase 42 kDa subunit [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
OSB_26000  ghrA; Glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
OSB_26830  ttuD_2; Putative hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
OSB_03590  ttuD_1; Putative hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
OSB_00820  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
OSB_00290  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
OSB_00300  serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
OSB_00600  serB; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
OSB_17300  hemA_2; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
OSB_13290  hemA_1; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
OSB_17050  lpd; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
OSB_04600  lpd3; Dihydrolipoyl dehydrogenase 3 [KO:K00382] [EC:1.8.1.4]
OSB_23980  Creatinase [KO:K08688] [EC:3.5.3.3]
OSB_22360  betA; Oxygen-dependent choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
OSB_22380  betB; NAD/NADP-dependent betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
OSB_26970  mlr_5; 4-methylaminobutanoate oxidase (formaldehyde-forming) [KO:K00315] [EC:1.5.8.4]
OSB_15100  mlr_2; 4-methylaminobutanoate oxidase (formaldehyde-forming) [KO:K00315] [EC:1.5.8.4]
OSB_15120  mlr_3; 4-methylaminobutanoate oxidase (formaldehyde-forming) [KO:K00315] [EC:1.5.8.4]
OSB_05340  mlr_1; 4-methylaminobutanoate oxidase (formaldehyde-forming) [KO:K00315] [EC:1.5.8.4]
OSB_30270  mlr_7; 4-methylaminobutanoate oxidase (formaldehyde-forming) [KO:K00315] [EC:1.5.8.4]
OSB_12670  gcvT_1; Aminomethyltransferase [KO:K00302] [EC:1.5.3.24 1.5.3.1]
OSB_12630  soxB_1; Sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
OSB_12680  Sarcosine oxidase, gamma subunit family [KO:K00305] [EC:1.5.3.24 1.5.3.1]
OSB_12660  Sarcosine oxidase, delta subunit family [KO:K00304] [EC:1.5.3.24 1.5.3.1]
OSB_10370  tdcG; L-serine dehydratase TdcG [KO:K01752] [EC:4.3.1.17]
OSB_24760  tdcB_2; L-threonine dehydratase catabolic TdcB [KO:K01754] [EC:4.3.1.19]
OSB_02990  tdcB_1; L-threonine dehydratase catabolic TdcB [KO:K01754] [EC:4.3.1.19]
OSB_00680  psdht_1; Phenylserine dehydratase [KO:K01754] [EC:4.3.1.19]
OSB_24240  trpA; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
OSB_24330  trpB; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
OSB_17100  putative peptidase [KO:K15783] [EC:3.5.4.44]
OSB_17110  tpa_1; Taurine--pyruvate aminotransferase [KO:K15785] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
otm00010  Glycolysis / Gluconeogenesis
otm00020  Citrate cycle (TCA cycle)
otm00230  Purine metabolism
otm00250  Alanine, aspartate and glutamate metabolism
otm00270  Cysteine and methionine metabolism
otm00290  Valine, leucine and isoleucine biosynthesis
otm00300  Lysine biosynthesis
otm00330  Arginine and proline metabolism
otm00460  Cyanoamino acid metabolism
otm00470  D-Amino acid metabolism
otm00564  Glycerophospholipid metabolism
otm00600  Sphingolipid metabolism
otm00620  Pyruvate metabolism
otm00630  Glyoxylate and dicarboxylate metabolism
otm00640  Propanoate metabolism
otm00680  Methane metabolism
otm00860  Porphyrin metabolism
otm00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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