KEGG   PATHWAY: pae00230
Entry
pae00230                    Pathway                                
Name
Purine metabolism - Pseudomonas aeruginosa PAO1
Class
Metabolism; Nucleotide metabolism
Pathway map
pae00230  Purine metabolism
pae00230

Module
pae_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:pae00230]
pae_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:pae00230]
pae_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:pae00230]
pae_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:pae00230]
pae_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:pae00230]
pae_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:pae00230]
pae_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:pae00230]
Other DBs
GO: 0006163 0042278
Organism
Pseudomonas aeruginosa PAO1 [GN:pae]
Gene
PA4971  aspP; adenosine diphosphate sugar pyrophosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
PA5176  ADP-ribose diphosphatase NudE [KO:K08312] [EC:3.6.1.-]
PA5322  algC; phosphomannomutase [KO:K15778] [EC:5.4.2.8 5.4.2.2]
PA4670  prs; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
PA3108  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
PA4855  purD; phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
PA0944  purN; phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
PA3751  purT; phosphoribosylglycinamide formyltransferase [KO:K08289] [EC:6.3.1.21]
PA3763  purL; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
PA0945  purM; phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
PA5425  purK; 5-(carboxyamino)imidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
PA5426  purE; 5-(carboxyamino)imidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
PA1013  purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
PA3516  adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
PA3517  adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
PA2629  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
PA4854  purH; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
PA1543  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
PA3625  surE; 5'-nucleotidase SurE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
PA5177  hydrolase [KO:K20881] [EC:3.1.3.-]
PA1574  hypothetical protein [KO:K09913] [EC:2.4.2.1 2.4.2.2]
PA1469  hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
PA4543  hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
PA4645  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
PA3770  guaB; inosine 5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
PA3807  ndk; nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
PA0387  non-canonical purine NTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
PA5298  xanthine phosphoribosyltransferase [KO:K03816] [EC:2.4.2.22]
PA1524  xdhA; xanthine dehydrogenase [KO:K13481] [EC:1.17.1.4]
PA1523  xdhB; xanthine dehydrogenase [KO:K13482] [EC:1.17.1.4]
PA1933  hydroxylase large subunit [KO:K11177] [EC:1.17.1.4]
PA1932  hydroxylase molybdopterin-containing subunit [KO:K11178] [EC:1.17.1.4]
PA1931  ferredoxin [KO:K13483]
PA3769  guaA; GMP synthase [KO:K01951] [EC:6.3.5.2]
PA1521  guanine deaminase [KO:K01487] [EC:3.5.4.3]
PA0134  guanine deaminase [KO:K01487] [EC:3.5.4.3]
PA2499  deaminase [KO:K01487] [EC:3.5.4.3]
PA5336  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
PA5497  nrdJa; ribonucleoside-diphosphate reductase [KO:K00525] [EC:1.17.4.1]
PA1156  nrdA; ribonucleotide-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
PA1155  nrdB; ribonucleotide-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
PA1920  nrdD; anaerobic ribonucleoside triphosphate reductase [KO:K21636] [EC:1.1.98.6]
PA1124  dgt; deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
PA3043  deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
PA5338  spoT; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
PA5241  ppx; exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
PA0934  relA; GTP pyrophosphokinase [KO:K00951] [EC:2.7.6.5]
PA3217  cyaB; protein CyaB [KO:K01768] [EC:4.6.1.1]
PA5272  cyaA; adenylate cyclase [KO:K05851] [EC:4.6.1.1]
PA4938  purA; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
PA3970  amn; AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
PA4115  hypothetical protein [KO:K06966] [EC:3.2.2.10 3.2.2.-]
PA0148  adenosine deaminase [KO:K21053] [EC:3.5.4.2]
PA3686  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
PA0935  nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
PA4969  cpdA; cAMP phosphodiesterase [KO:K03651] [EC:3.1.4.53]
PA0590  apaH; bis(5'-nucleosyl)-tetraphosphatase [KO:K01525] [EC:3.6.1.41]
PA4442  cysN; bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase [KO:K00955] [EC:2.7.7.4 2.7.1.25]
PA1393  cysC; adenylyl-sulfate kinase [KO:K00860] [EC:2.7.1.25]
PA4443  cysD; sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
PA1518  5-hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
PA1516  hypothetical protein [KO:K13485] [EC:4.1.1.97]
PA1517  hypothetical protein [KO:K16842] [EC:3.5.2.5]
PA1515  alc; allantoicase [KO:K01477] [EC:3.5.3.4]
PA1140  hypothetical protein [KO:K14977] [EC:3.5.3.26]
PA1514  ureidoglycolate hydrolase [KO:K01483] [EC:4.3.2.3]
PA4868  ureC; urease subunit alpha [KO:K01428] [EC:3.5.1.5]
PA4867  ureB; urease subunit beta [KO:K01429] [EC:3.5.1.5]
PA4865  ureA; urease subunit gamma [KO:K01430] [EC:3.5.1.5]
PA5173  arcC; carbamate kinase [KO:K00926] [EC:2.7.2.2]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
pae00030  Pentose phosphate pathway
pae00220  Arginine biosynthesis
pae00250  Alanine, aspartate and glutamate metabolism
pae00260  Glycine, serine and threonine metabolism
pae00340  Histidine metabolism
pae00630  Glyoxylate and dicarboxylate metabolism
pae00730  Thiamine metabolism
pae00740  Riboflavin metabolism
pae00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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