KEGG   PATHWAY: paeg00260
Entry
paeg00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas aeruginosa YL84
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
paeg00260  Glycine, serine and threonine metabolism
paeg00260

Module
paeg_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:paeg00260]
paeg_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:paeg00260]
paeg_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:paeg00260]
paeg_M00555  Betaine biosynthesis, choline => betaine [PATH:paeg00260]
paeg_M00621  Glycine cleavage system [PATH:paeg00260]
paeg_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:paeg00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas aeruginosa YL84 [GN:paeg]
Gene
AI22_12020  aspartokinase [KO:K00928] [EC:2.7.2.4]
AI22_24085  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
AI22_27185  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
AI22_04320  homoserine kinase [KO:K02204] [EC:2.7.1.39]
AI22_16775  thrH; phosphoserine phosphatase [KO:K02203] [EC:3.1.3.3 2.7.1.39]
AI22_27180  threonine synthase [KO:K01733] [EC:4.2.3.1]
AI22_12010  threonine aldolase [KO:K01620] [EC:4.1.2.48]
AI22_04740  threonine aldolase [KO:K01620] [EC:4.1.2.48]
AI22_09100  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AI22_20515  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AI22_04730  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AI22_08970  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
AI22_28265  2-ketogluconate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
AI22_13250  glycerate kinase [KO:K00865] [EC:2.7.1.165]
AI22_15055  TtuD3 hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
AI22_06230  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
AI22_02310  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AI22_24330  MFS transporter [KO:K00831] [EC:2.6.1.52]
AI22_07085  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
AI22_01765  amine oxidase [KO:K00274] [EC:1.4.3.4]
AI22_20520  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
AI22_05790  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
AI22_20505  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
AI22_05780  gcvT; glycine cleavage system aminomethyltransferase T [KO:K00605] [EC:2.1.2.10]
AI22_15905  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AI22_07750  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AI22_19485  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AI22_20525  glycine cleavage system protein H [KO:K02437]
AI22_05785  glycine cleavage system protein H [KO:K02437]
AI22_07935  glycine cleavage system protein H [KO:K02437]
AI22_08470  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
AI22_04950  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
AI22_04945  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
AI22_04755  Rieske (2Fe-2S) protein [KO:K00479] [EC:1.14.13.251]
AI22_04750  ferredoxin [KO:K21832] [EC:1.14.13.251]
AI22_04820  N-methylproline demethylase [KO:K21833] [EC:1.5.7.3]
AI22_04815  (Fe-S)-binding protein [KO:K21834]
AI22_04810  electron transfer flavoprotein subunit alpha [KO:K25960]
AI22_04805  electron transfer flavoprotein subunit beta [KO:K25961]
AI22_04715  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
AI22_04725  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
AI22_04710  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
AI22_04720  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
AI22_01875  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
AI22_01870  cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
AI22_04915  serine dehydratase [KO:K01752] [EC:4.3.1.17]
AI22_20510  serine dehydratase [KO:K01752] [EC:4.3.1.17]
AI22_15325  L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
AI22_02230  L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
AI22_11750  hypothetical protein [KO:K01754] [EC:4.3.1.19]
AI22_25325  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
AI22_03730  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
AI22_03725  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
AI22_19210  diadenosine tetraphosphatase [KO:K00836] [EC:2.6.1.76]
AI22_20305  diadenosine tetraphosphatase [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
paeg00010  Glycolysis / Gluconeogenesis
paeg00020  Citrate cycle (TCA cycle)
paeg00230  Purine metabolism
paeg00250  Alanine, aspartate and glutamate metabolism
paeg00270  Cysteine and methionine metabolism
paeg00290  Valine, leucine and isoleucine biosynthesis
paeg00300  Lysine biosynthesis
paeg00330  Arginine and proline metabolism
paeg00460  Cyanoamino acid metabolism
paeg00470  D-Amino acid metabolism
paeg00564  Glycerophospholipid metabolism
paeg00600  Sphingolipid metabolism
paeg00620  Pyruvate metabolism
paeg00630  Glyoxylate and dicarboxylate metabolism
paeg00640  Propanoate metabolism
paeg00680  Methane metabolism
paeg00860  Porphyrin metabolism
paeg00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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