KEGG   PATHWAY: pals00260
Entry
pals00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Paracoccus albus
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pals00260  Glycine, serine and threonine metabolism
pals00260

Module
pals_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pals00260]
pals_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:pals00260]
pals_M00621  Glycine cleavage system [PATH:pals00260]
pals_M00919  Ectoine degradation, ectoine => aspartate [PATH:pals00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Paracoccus albus [GN:pals]
Gene
PAF20_08300  aspartate kinase [KO:K00928] [EC:2.7.2.4]
PAF20_09700  aspartate kinase [KO:K00928] [EC:2.7.2.4]
PAF20_15645  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
PAF20_16395  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
PAF20_09510  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
PAF20_01815  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
PAF20_10155  beta-eliminating lyase-related protein [KO:K01620] [EC:4.1.2.48]
PAF20_10420  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
PAF20_08435  aminotransferase class V-fold PLP-dependent enzyme [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
PAF20_03635  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
PAF20_07445  glycerate kinase [KO:K11529] [EC:2.7.1.165]
PAF20_00360  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
PAF20_00715  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PAF20_06875  NAD(P)-dependent oxidoreductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PAF20_10705  NAD(P)-dependent oxidoreductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PAF20_00720  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
PAF20_15335  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
PAF20_11075  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
PAF20_11080  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
PAF20_05770  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
PAF20_14640  tyramine oxidase [KO:K00276] [EC:1.4.3.21]
PAF20_15820  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
PAF20_15805  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
PAF20_07845  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
PAF20_11120  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
PAF20_15810  gcvH; glycine cleavage system protein GcvH [KO:K02437]
PAF20_07500  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
PAF20_05385  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
PAF20_08320  eutB; hydroxyectoine utilization dehydratase EutB [KO:K01754] [EC:4.3.1.19]
PAF20_08440  pyridoxal-phosphate dependent enzyme [KO:K01754] [EC:4.3.1.19]
PAF20_15850  ilvA; threonine ammonia-lyase IlvA [KO:K01754] [EC:4.3.1.19]
PAF20_08690  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
PAF20_08185  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
PAF20_10135  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
PAF20_08290  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
PAF20_08285  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
PAF20_08295  ectoine synthase [KO:K06720] [EC:4.2.1.108]
PAF20_08310  doeA; ectoine hydrolase DoeA [KO:K15783] [EC:3.5.4.44]
PAF20_08305  doeB; N(2)-acetyl-L-2,4-diaminobutanoate deacetylase DoeB [KO:K15784] [EC:3.5.1.125]
PAF20_08365  aspartate aminotransferase family protein [KO:K15785] [EC:2.6.1.76]
PAF20_08360  NAD-dependent succinate-semialdehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pals00010  Glycolysis / Gluconeogenesis
pals00020  Citrate cycle (TCA cycle)
pals00230  Purine metabolism
pals00250  Alanine, aspartate and glutamate metabolism
pals00270  Cysteine and methionine metabolism
pals00290  Valine, leucine and isoleucine biosynthesis
pals00300  Lysine biosynthesis
pals00330  Arginine and proline metabolism
pals00460  Cyanoamino acid metabolism
pals00470  D-Amino acid metabolism
pals00564  Glycerophospholipid metabolism
pals00600  Sphingolipid metabolism
pals00620  Pyruvate metabolism
pals00630  Glyoxylate and dicarboxylate metabolism
pals00640  Propanoate metabolism
pals00680  Methane metabolism
pals00860  Porphyrin metabolism
pals00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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