KEGG   PATHWAY: pcf04150
Entry
pcf04150                    Pathway                                
Name
mTOR signaling pathway - Polistes canadensis
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
pcf04150  mTOR signaling pathway
pcf04150

Organism
Polistes canadensis [GN:pcf]
Gene
106785295  Y+L amino acid transporter 2 isoform X1 [KO:K13780]
106785178  Y+L amino acid transporter 2 [KO:K13780]
106789739  neutral and basic amino acid transport protein rBAT isoform X1 [KO:K06519]
106790197  sodium-coupled neutral amino acid transporter 9-like [KO:K14995]
106784270  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
106786999  V-type proton ATPase subunit B [KO:K02147]
106789057  V-type proton ATPase subunit C isoform X1 [KO:K02148]
106785500  V-type proton ATPase subunit D-like [KO:K02149]
106787260  V-type proton ATPase subunit D [KO:K02149]
106785558  V-type proton ATPase subunit E [KO:K02150]
106791579  V-type proton ATPase subunit F [KO:K02151]
106791715  V-type proton ATPase subunit G [KO:K02152]
106785519  V-type proton ATPase subunit H isoform X1 [KO:K02144]
106787946  ragulator complex protein LAMTOR1 isoform X1 [KO:K20397]
106793714  ragulator complex protein LAMTOR2 homolog [KO:K20398]
106789985  ragulator complex protein LAMTOR3-A [KO:K04370]
106787449  ragulator complex protein LAMTOR4 homolog [KO:K20399]
106792799  uncharacterized protein LOC106792799 isoform X1 [KO:K16344]
106785834  folliculin isoform X1 [KO:K09594]
106789804  folliculin-interacting protein 2 [KO:K20401]
106791011  ras-related GTP-binding protein A [KO:K16185]
106789243  ras-related GTP-binding protein C [KO:K16186]
106788446  WD repeat-containing protein mio [KO:K20407]
106786933  nucleoporin seh1-A [KO:K14299]
106783805  WD repeat-containing protein 24 isoform X1 [KO:K20408]
106790288  WD repeat-containing protein 59 isoform X1 [KO:K20409]
106784718  protein SEC13 homolog [KO:K14004]
106783800  DEP domain-containing protein 5 isoform X1 [KO:K20404]
106788386  nitrogen permease regulator 2-like protein isoform X1 [KO:K20405]
106789588  nitrogen permease regulator 3-like protein isoform X1 [KO:K20406]
106788562  S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
106792114  regulatory-associated protein of mTOR isoform X1 [KO:K07204]
106789371  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
106787819  target of rapamycin complex subunit lst8 [KO:K08266]
106792836  TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
106786254  CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
106788540  phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
106792966  serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
106785087  eukaryotic translation initiation factor 4E type 2 [KO:K03259]
106787443  eukaryotic translation initiation factor 4E-1A-like isoform X1 [KO:K03259]
106793029  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
106792200  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
106789010  eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
106792291  40S ribosomal protein S6-like [KO:K02991]
106785049  40S ribosomal protein S6-like [KO:K02991]
106790399  serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
106785168  protein Mo25 isoform X1 [KO:K08272]
106789443  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
106789129  hamartin isoform X1 [KO:K07206]
106785437  tuberin [KO:K07207]
106788806  TBC1 domain family member 7 [KO:K20396]
106793563  GTP-binding protein Rheb homolog [KO:K07208]
106793564  GTP-binding protein Rheb homolog [KO:K07208]
106792535  protein Wnt-1 [KO:K03209]
106790923  protein Wnt-1-like [KO:K00408]
106789889  protein Wnt-5b-like [KO:K00444]
106792536  protein Wnt-6-like [KO:K00445]
106791180  protein Wnt-7b [KO:K00572]
106784989  protein Wnt-10b-like [KO:K01357]
106787116  protein Wnt-11b-1-like [KO:K01384]
106784705  frizzled-2 [KO:K02432]
106785545  frizzled-4 [KO:K02354]
106787556  frizzled-2 isoform X1 [KO:K02375]
106790367  frizzled-9-like [KO:K02842]
106793253  low-density lipoprotein receptor-related protein 6 [KO:K03068]
106784269  segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
106787307  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
106785497  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K07209] [EC:2.7.11.10]
106791661  LIRP-like [KO:K04526]
106790925  protein enhancer of sevenless 2B [KO:K04364]
106784021  protein son of sevenless isoform X1 [KO:K03099]
106787585  ras-like protein 1 [KO:K07827]
106786260  raf homolog serine/threonine-protein kinase phl [KO:K04365] [EC:2.7.11.1]
106790392  dual specificity mitogen-activated protein kinase kinase dSOR1 [KO:K04368] [EC:2.7.12.2]
106786258  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106793902  ribosomal protein S6 kinase 2 beta [KO:K04373] [EC:2.7.11.1]
106792141  insulin receptor substrate 1 isoform X1 [KO:K16172]
106792271  uncharacterized protein LOC106792271 [KO:K02649]
106789415  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
106786252  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106787987  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
106783605  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106785572  target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
106791834  rapamycin-insensitive companion of mTOR [KO:K08267]
106786487  ras-like GTP-binding protein Rho1 isoform X1 [KO:K04513]
106790123  protein kinase C, brain isozyme isoform X1 [KO:K02677] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
pcf00561  Glycerolipid metabolism
pcf04140  Autophagy - animal
KO pathway
ko04150   
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