KEGG   PATHWAY: pcs00260
Entry
pcs00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Penicillium rubens
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pcs00260  Glycine, serine and threonine metabolism
pcs00260

Module
pcs_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pcs00260]
pcs_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pcs00260]
pcs_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:pcs00260]
pcs_M00621  Glycine cleavage system [PATH:pcs00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Penicillium rubens [GN:pcs]
Gene
N7525_008524  uncharacterized protein [KO:K00928] [EC:2.7.2.4]
N7525_008735  Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
N7525_003275  uncharacterized protein [KO:K00003] [EC:1.1.1.3]
N7525_008547  uncharacterized protein [KO:K00872] [EC:2.7.1.39]
N7525_008843  uncharacterized protein [KO:K01733] [EC:4.2.3.1]
N7525_002344  uncharacterized protein [KO:K01620] [EC:4.1.2.48]
N7525_005605  Aromatic amino acid beta-eliminating lyase/threonine aldolase [KO:K01620] [EC:4.1.2.48]
N7525_001014  uncharacterized protein [KO:K00600] [EC:2.1.2.1]
N7525_003660  uncharacterized protein [KO:K00600] [EC:2.1.2.1]
N7525_011404  Pyridoxal phosphate-dependent transferase major region subdomain 2 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
N7525_006512  uncharacterized protein [KO:K00865] [EC:2.7.1.165]
N7525_001011  uncharacterized protein [KO:K15633] [EC:5.4.2.12]
N7525_004227  uncharacterized protein [KO:K15918] [EC:2.7.1.31]
N7525_003571  uncharacterized protein [KO:K15918] [EC:2.7.1.31]
N7525_001518  uncharacterized protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
N7525_008514  uncharacterized protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
N7525_002076  uncharacterized protein [KO:K00831] [EC:2.6.1.52]
N7525_008764  uncharacterized protein [KO:K01079] [EC:3.1.3.3]
N7525_007066  uncharacterized protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
N7525_005019  uncharacterized protein [KO:K00643] [EC:2.3.1.37]
N7525_011347  uncharacterized protein [KO:K00274] [EC:1.4.3.4]
N7525_006941  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
N7525_003815  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
N7525_002449  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
N7525_010633  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
N7525_004887  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
N7525_004613  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
N7525_000039  uncharacterized protein [KO:K00281] [EC:1.4.4.2]
N7525_010993  uncharacterized protein [KO:K00605] [EC:2.1.2.10]
N7525_008904  uncharacterized protein [KO:K00382] [EC:1.8.1.4]
N7525_001105  uncharacterized protein [KO:K02437]
N7525_006823  uncharacterized protein [KO:K00273] [EC:1.4.3.3]
N7525_007039  uncharacterized protein [KO:K00273] [EC:1.4.3.3]
N7525_000098  uncharacterized protein [KO:K00273] [EC:1.4.3.3]
N7525_009069  uncharacterized protein [KO:K00273] [EC:1.4.3.3]
N7525_005836  CDP-alcohol phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
N7525_005258  uncharacterized protein [KO:K00130] [EC:1.2.1.8]
N7525_003723  uncharacterized protein [KO:K00309] [EC:1.5.3.10]
N7525_004055  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
N7525_007564  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
N7525_000367  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
N7525_004843  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
N7525_001596  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
N7525_003205  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
N7525_003118  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
N7525_010577  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
N7525_009886  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
N7525_003629  uncharacterized protein [KO:K01697] [EC:4.2.1.22]
N7525_007023  uncharacterized protein [KO:K01758] [EC:4.4.1.1]
N7525_010249  uncharacterized protein [KO:K01754] [EC:4.3.1.19]
N7525_003396  uncharacterized protein [KO:K01754] [EC:4.3.1.19]
N7525_002462  uncharacterized protein [KO:K01754] [EC:4.3.1.19]
N7525_003439  uncharacterized protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
N7525_011361  uncharacterized protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
N7525_006917  uncharacterized protein [KO:K20498] [EC:4.3.1.18]
N7525_010248  uncharacterized protein [KO:K20498] [EC:4.3.1.18]
N7525_002686  uncharacterized protein [KO:K20498] [EC:4.3.1.18]
N7525_006869  uncharacterized protein [KO:K01694] [EC:4.2.1.20]
N7525_006092  uncharacterized protein [KO:K01694] [EC:4.2.1.20]
N7525_005023  uncharacterized protein [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pcs00010  Glycolysis / Gluconeogenesis
pcs00020  Citrate cycle (TCA cycle)
pcs00230  Purine metabolism
pcs00250  Alanine, aspartate and glutamate metabolism
pcs00270  Cysteine and methionine metabolism
pcs00290  Valine, leucine and isoleucine biosynthesis
pcs00300  Lysine biosynthesis
pcs00330  Arginine and proline metabolism
pcs00460  Cyanoamino acid metabolism
pcs00470  D-Amino acid metabolism
pcs00564  Glycerophospholipid metabolism
pcs00600  Sphingolipid metabolism
pcs00620  Pyruvate metabolism
pcs00630  Glyoxylate and dicarboxylate metabolism
pcs00640  Propanoate metabolism
pcs00680  Methane metabolism
pcs00860  Porphyrin metabolism
pcs00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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