KEGG   PATHWAY: pdf00520
Entry
pdf00520                    Pathway                                
Name
Amino sugar and nucleotide sugar metabolism - Clostridioides difficile 630Derm
Class
Metabolism; Carbohydrate metabolism
Pathway map
pdf00520  Amino sugar and nucleotide sugar metabolism
pdf00520

Module
pdf_M00549  Nucleotide sugar biosynthesis, glucose => UDP-glucose [PATH:pdf00520]
pdf_M00909  UDP-N-acetyl-D-glucosamine biosynthesis, prokaryotes, glucose => UDP-GlcNAc [PATH:pdf00520]
Other DBs
GO: 0006040 0009225
Organism
Clostridioides difficile 630Derm [GN:pdf]
Gene
CD630DERM_26660  ptsG-A; PTS system, glucose-specific IIA component [KO:K02777] [EC:2.7.1.-]
CD630DERM_25120  PTS system, glucose-like IIA component [KO:K02777] [EC:2.7.1.-]
CD630DERM_30270  PTS system, glucose-like IIA component [KO:K02777] [EC:2.7.1.-]
CD630DERM_31030  PTS system, glucose-like IIA component [KO:K02777] [EC:2.7.1.-]
CD630DERM_30580  PTS system, alpha-glucoside-specific IIAcomponent [KO:K02777] [EC:2.7.1.-]
CD630DERM_30890  PTS system, glucose-like IIBC component [KO:K02804] [EC:2.7.1.193]
CD630DERM_10100  nagA; N-acetylglucosamine-6-phosphate deacetylase(GlcNAc 6-P deacetylase) [KO:K01443] [EC:3.5.1.25]
CD630DERM_34530  N-acetylglucosamine-6-phosphate deacetylase [KO:K01443] [EC:3.5.1.25]
CD630DERM_10110  nagB; Glucosamine-6-phosphate deaminase [KO:K02564] [EC:3.5.99.6]
CD630DERM_18060  scrK; Fructokinase [KO:K00847] [EC:2.7.1.4]
CD630DERM_01200  glmS; Glucosamine--fructose-6-phosphateaminotransferas e [isomerizing] [KO:K00820] [EC:2.6.1.16]
CD630DERM_01190  glmM; Phosphoglucosamine mutase [KO:K03431] [EC:5.4.2.10]
CD630DERM_35150  glmU; Bifunctional protein GlmU [Includes:UDP-N-acetylglucosamine pyrophosphorylase; Glucosamine-1-phosphate N-acetyltransferase] [KO:K04042] [EC:2.7.7.23 2.3.1.157]
CD630DERM_30460  murQ; N-acetylmuramic acid 6-phosphate etherase [KO:K07106] [EC:4.2.1.126]
CD630DERM_30510  anmK; Anhydro-N-acetylmuramic acid kinase (AnhMurNAckinase) [KO:K09001] [EC:2.7.1.170]
CD630DERM_01230  murA; UDP-N-acetylglucosamine1-carboxyvinyltransferase [KO:K00790] [EC:2.5.1.7]
CD630DERM_34020  murB; UDP-N-acetylenolpyruvoylglucosamine reductase [KO:K00075] [EC:1.3.1.98]
CD630DERM_22410  nanE; N-acetylmannosamine-6-phosphate 2-epimerase(ManNAc-6-P epimerase) [KO:K01788] [EC:5.1.3.9]
CD630DERM_22400  nanA; Acetylneuraminate lyase [KO:K01639] [EC:4.1.3.3]
CD630DERM_10330  mnaA; UDP-N-acetylglucosamine 2-epimerase(UDP-GlcNAc-2-epimerase) [KO:K01791] [EC:5.1.3.14]
CD630DERM_00330  putative glycoside hydrolase [KO:K01198] [EC:3.2.1.37]
CD630DERM_25100  PTS system, glucose-like IIBC component [KO:K02791] [EC:2.7.1.199 2.7.1.208]
CD630DERM_30300  PTS system, glucose-like IIBC component [KO:K02791] [EC:2.7.1.199 2.7.1.208]
CD630DERM_13360  PTS system, glucose-like IIBC component [KO:K02791] [EC:2.7.1.199 2.7.1.208]
CD630DERM_26670  ptsG-BC; PTS system, glucose-specific IIBC component [KO:K20118] [EC:2.7.1.199]
CD630DERM_24590  putative glucokinase, ROK family [KO:K25026] [EC:2.7.1.2]
CD630DERM_15770  pgm; Alpha-phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
CD630DERM_27800  pgmA; Alpha-phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
CD630DERM_34880  gtaB1; UTP--glucose-1-phosphate uridylyltransferase(general stress protein 33) [KO:K00963] [EC:2.7.7.9]
CD630DERM_27150  gtaB; UTP--glucose-1-phosphate uridylyltransferase [KO:K00963] [EC:2.7.7.9]
CD630DERM_27710  rkpK; UDP-glucose 6-dehydrogenase [KO:K00012] [EC:1.1.1.22]
CD630DERM_13400  putative galactose-1-phosphateuridylyltransferase [KO:K00965] [EC:2.7.7.12]
CD630DERM_27140  galE; UDP-glucose 4-epimerase [KO:K01784] [EC:5.1.3.2]
CD630DERM_30670  xynA; PTS system, xyloside-specific IIA component [KO:K02793] [EC:2.7.1.191]
CD630DERM_02840  PTS system, mannose/fructose/sorbose IIAcomponent [KO:K02793] [EC:2.7.1.191]
CD630DERM_04910  PTS system, mannose/fructose/sorbose IIAcomponent [KO:K02793] [EC:2.7.1.191]
CD630DERM_10740  PTS system, mannose/fructose/sorbose IIAcomponent [KO:K02793] [EC:2.7.1.191]
CD630DERM_30680  xynB; PTS system, xyloside-specific IIB component [KO:K02794] [EC:2.7.1.191]
CD630DERM_30700  xynC; PTS system, xyloside-specific IIC component [KO:K02795]
CD630DERM_32770  PTS system, mannose/fructose/sorbose IICcomponent [KO:K02795]
CD630DERM_30690  xynD; PTS system, xyloside-specific IID component [KO:K02796]
CD630DERM_04940  PTS system, mannose/fructose/sorbose IIDcomponent [KO:K02796]
CD630DERM_32850  pgi; Glucose-6-phosphate isomerase (GPI)(Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase)(PHI) [KO:K01810] [EC:5.3.1.9]
CD630DERM_24910  pmi; Mannose-6-phosphate isomerase (Phosphomannoseisomerase) (PMI) (Phosphohexomutase) [KO:K01809] [EC:5.3.1.8]
CD630DERM_27790  manC; putative mannose-1-phosphateguanylyltransferase [KO:K00971] [EC:2.7.7.13]
CD630DERM_08820  glgC; Glucose-1-phosphate adenylyltransferase [KO:K00975] [EC:2.7.7.27]
CD630DERM_08830  glgD; Glycogen biosynthesis protein [KO:K00975] [EC:2.7.7.27]
Compound
C00029  UDP-glucose
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00052  UDP-alpha-D-galactose
C00085  D-Fructose 6-phosphate
C00095  D-Fructose
C00096  GDP-mannose
C00103  D-Glucose 1-phosphate
C00128  CMP-N-acetylneuraminate
C00140  N-Acetyl-D-glucosamine
C00159  D-Mannose
C00167  UDP-glucuronate
C00181  D-Xylose
C00190  UDP-D-xylose
C00191  D-Glucuronate
C00203  UDP-N-acetyl-D-galactosamine
C00216  D-Arabinose
C00259  L-Arabinose
C00267  alpha-D-Glucose
C00270  N-Acetylneuraminate
C00275  D-Mannose 6-phosphate
C00325  GDP-L-fucose
C00329  D-Glucosamine
C00333  D-Galacturonate
C00352  D-Glucosamine 6-phosphate
C00357  N-Acetyl-D-glucosamine 6-phosphate
C00394  GDP-glucose
C00446  alpha-D-Galactose 1-phosphate
C00461  Chitin
C00498  ADP-glucose
C00501  CDP-glucose
C00617  UDP-D-galacturonate
C00636  D-Mannose 1-phosphate
C00645  N-Acetyl-D-mannosamine
C00668  alpha-D-Glucose 6-phosphate
C00714  Pectin
C00734  Chitosan
C00935  UDP-L-arabinose
C00976  GDP-D-mannuronate
C00984  alpha-D-Galactose
C00996  Ferricytochrome b5
C00999  Ferrocytochrome b5
C01019  L-Fucose
C01050  UDP-N-acetylmuramate
C01132  N-Acetyl-D-galactosamine
C01170  UDP-N-acetyl-D-mannosamine
C01219  CDP-4-dehydro-6-deoxy-D-glucose
C01222  GDP-4-dehydro-6-deoxy-D-mannose
C01623  UDP-apiose
C01674  Chitobiose
C01788  CDP-abequose
C02199  UDP-L-rhamnose
C02280  GDP-L-galactose
C02352  1,4-beta-D-Xylan
C02474  Arabinan
C02713  N-Acetylmuramate
C02977  GDP-6-deoxy-D-talose
C02985  L-Fucose 1-phosphate
C03117  GDP-6-deoxy-D-mannose
C03410  N-Glycoloyl-neuraminate
C03598  CDP-3,6-dideoxy-D-glucose
C03599  CDP-3,6-dideoxy-D-mannose
C03691  CMP-N-glycoloylneuraminate
C03733  UDP-alpha-D-galactofuranose
C03906  beta-L-Arabinose 1-phosphate
C04037  1-Phospho-alpha-D-galacturonate
C04089  UDP-4-dehydro-6-deoxy-D-glucose
C04257  N-Acetyl-D-mannosamine 6-phosphate
C04297  CDP-4-dehydro-3,6-dideoxy-D-glucose
C04501  N-Acetyl-alpha-D-glucosamine 1-phosphate
C04573  UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate
C04613  UDP-2-acetamido-4-dehydro-2,6-dideoxyglucose
C04630  UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucose
C04631  UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
C05385  D-Glucuronate 1-phosphate
C06023  D-Glucosaminide
C06156  alpha-D-Glucosamine 1-phosphate
C06240  UDP-N-acetyl-D-mannosaminouronate
C06241  N-Acetylneuraminate 9-phosphate
C06377  D-Galactosamine 6-phosphate
C11521  UDP-6-sulfoquinovose
C13952  UDP-N-acetyl-D-galactosaminuronic acid
C15925  GDP-L-gulose
C16153  UDP-L-Ara4N
C16154  UDP-L-Ara4FN
C16155  UDP-L-Ara4O
C16156  Undecaprenyl phosphate alpha-L-Ara4FN
C16157  Undecaprenyl phosphate alpha-L-Ara4N
C16183  alpha-D-Arabinopyranose 1-phosphate
C16698  N-Acetylmuramic acid 6-phosphate
C17269  GDP-D-arabinopyranose
C17326  CDP-4-dehydro-3,6-dideoxy-D-glucose epimer
C17327  CDP-ascarylose
C17328  UDP-4-keto-rhamnose
C18060  N-Acetyl-alpha-D-galactosamine 1-phosphate
C18094  UDP-L-arabinofuranose
C19725  UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate
C19745  UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate
C19769  1,6-Anhydro-N-acetyl-beta-muramate
C19823  UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hexos-4-ulose
C19961  UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine
C19971  UDP-2,4-bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose
C19972  2,4-Bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose
C20082  Pseudaminic acid
C20083  CMP-pseudaminic acid
C20357  UDP-N,N'-diacetylbacillosamine
C20359  UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate
C20395  UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate
C20418  N,N'-Diacetyllegionaminate
C20419  CMP-N,N'-diacetyllegionaminate
C20424  2,4-Diacetamido-2,4,6-trideoxy-D-mannopyranose
C20638  GDP-4-amino-4,6-dideoxy-alpha-D-mannose
C20672  GDP-4-acetamido-4,6-dideoxy-alpha-D-mannose
C20934  3-Deoxy-D-glycero-D-galacto-non-2-ulopyranosonate
C21027  N-Acetylmuramic acid alpha-1-phosphate
C21383  3-Deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate
C21384  CMP-3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate
C22029  alpha-D-Galactosamine 1-phosphate
Reference
PMID:2793832
  Authors
Wyk P, Reeves P
  Title
Identification and sequence of the gene for abequose synthase, which confers antigenic specificity on group B salmonellae: homology with galactose epimerase.
  Journal
J Bacteriol 171:5687-93 (1989)
DOI:10.1128/JB.171.10.5687-5693.1989
Reference
PMID:8071227
  Authors
Thorson JS, Lo SF, Ploux O, He X, Liu HW
  Title
Studies of the biosynthesis of 3,6-dideoxyhexoses: molecular cloning and characterization of the asc (ascarylose) region from Yersinia pseudotuberculosis serogroup VA.
  Journal
J Bacteriol 176:5483-93 (1994)
DOI:10.1128/JB.176.17.5483-5493.1994
Reference
PMID:8444803
  Authors
Kessler AC, Haase A, Reeves PR
  Title
Molecular analysis of the 3,6-dideoxyhexose pathway genes of Yersinia pseudotuberculosis serogroup IIA.
  Journal
J Bacteriol 175:1412-22 (1993)
DOI:10.1128/JB.175.5.1412-1422.1993
Reference
PMID:9811644
  Authors
Danese PN, Oliver GR, Barr K, Bowman GD, Rick PD, Silhavy TJ
  Title
Accumulation of the enterobacterial common antigen lipid II biosynthetic intermediate stimulates degP transcription in Escherichia coli.
  Journal
J Bacteriol 180:5875-84 (1998)
DOI:10.1128/JB.180.22.5875-5884.1998
Reference
  Authors
Skurnik M, Peippo A, Ervela E
  Title
Characterization of the O-antigen gene clusters of Yersinia pseudotuberculosis and the cryptic O-antigen gene cluster of Yersinia pestis shows that the plague bacillus is most closely related to and has evolved from Y. pseudotuberculosis serotype O:1b.
  Journal
Mol Microbiol 37:316-30 (2000)
DOI:10.1046/j.1365-2958.2000.01993.x
Reference
  Authors
Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV
  Title
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
  Journal
Nature 406:959-64 (2000)
DOI:10.1038/35023079
Reference
  Authors
Ringenberg M, Lichtensteiger C, Vimr E
  Title
Redirection of sialic acid metabolism in genetically engineered Escherichia coli.
  Journal
Glycobiology 11:533-9 (2001)
DOI:10.1093/glycob/11.7.533
Reference
  Authors
McCoy AJ, Sandlin RC, Maurelli AT
  Title
In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistance.
  Journal
J Bacteriol 185:1218-28 (2003)
DOI:10.1128/JB.185.4.1218-1228.2003
Reference
  Authors
JACOBSON B, DAVIDSON EA
  Title
Biosynthesis of uronic acids by skin enzymes. I. Uridine diphosphate-D-glucuronic acid-5-epimerase.
  Journal
J Biol Chem 237:638-42 (1962)
Reference
  Authors
Seifert GJ
  Title
Nucleotide sugar interconversions and cell wall biosynthesis: how to bring the inside to the outside.
  Journal
Curr Opin Plant Biol 7:277-84 (2004)
DOI:10.1016/j.pbi.2004.03.004
Reference
  Authors
Uehara T, Park JT
  Title
The N-acetyl-D-glucosamine kinase of Escherichia coli and its role in murein recycling.
  Journal
J Bacteriol 186:7273-9 (2004)
DOI:10.1128/JB.186.21.7273-7279.2004
Reference
  Authors
Breazeale SD, Ribeiro AA, McClerren AL, Raetz CR.
  Title
A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose.
  Journal
J Biol Chem 280:14154-67 (2005)
DOI:10.1074/jbc.M414265200
Reference
  Authors
Williams GJ, Breazeale SD, Raetz CR, Naismith JH.
  Title
Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis.
  Journal
J Biol Chem 280:23000-8 (2005)
DOI:10.1074/jbc.M501534200
Reference
  Authors
Maliekal P, Vertommen D, Delpierre G, Van Schaftingen E
  Title
Identification of the sequence encoding N-acetylneuraminate-9-phosphate phosphatase.
  Journal
Glycobiology 16:165-72 (2006)
DOI:10.1093/glycob/cwj050
Reference
  Authors
Campbell CT, Yarema KJ
  Title
Large-scale approaches for glycobiology.
  Journal
Genome Biol 6:236 (2005)
DOI:10.1186/gb-2005-6-11-236
Reference
  Authors
Uehara T, Suefuji K, Jaeger T, Mayer C, Park JT
  Title
MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall.
  Journal
J Bacteriol 188:1660-2 (2006)
DOI:10.1128/JB.188.4.1660-1662.2006
Reference
  Authors
Lanot A, Hodge D, Jackson RG, George GL, Elias L, Lim EK, Vaistij FE, Bowles DJ
  Title
The glucosyltransferase UGT72E2 is responsible for monolignol 4-O-glucoside production in Arabidopsis thaliana.
  Journal
Plant J 48:286-95 (2006)
DOI:10.1111/j.1365-313X.2006.02872.x
Reference
  Authors
Muller R, Morant M, Jarmer H, Nilsson L, Nielsen TH
  Title
Genome-wide analysis of the Arabidopsis leaf transcriptome reveals interaction of phosphate and sugar metabolism.
  Journal
Plant Physiol 143:156-71 (2007)
DOI:10.1104/pp.106.090167
Reference
  Authors
Oka T, Nemoto T, Jigami Y
  Title
Functional analysis of Arabidopsis thaliana RHM2/MUM4, a multidomain protein involved in UDP-D-glucose to UDP-L-rhamnose conversion.
  Journal
J Biol Chem 282:5389-403 (2007)
DOI:10.1074/jbc.M610196200
Reference
  Authors
Greenberg DE, Porcella SF, Zelazny AM, Virtaneva K, Sturdevant DE, Kupko JJ 3rd, Barbian KD, Babar A, Dorward DW, Holland SM.
  Title
Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis.
  Journal
J Bacteriol 189:8727-36 (2007)
DOI:10.1128/JB.00793-07
Reference
  Authors
Kotake T, Hojo S, Tajima N, Matsuoka K, Koyama T, Tsumuraya Y
  Title
A bifunctional enzyme with L-fucokinase and GDP-L-fucose pyrophosphorylase activities salvages free L-fucose in Arabidopsis.
  Journal
J Biol Chem 283:8125-35 (2008)
DOI:10.1074/jbc.M710078200
Reference
  Authors
Vorholter FJ, Schneiker S, Goesmann A, Krause L, Bekel T, Kaiser O, Linke B, Patschkowski T, Ruckert C, Schmid J, Sidhu VK, Sieber V, Tauch A, Watt SA, Weisshaar B, Becker A, Niehaus K, Puhler A.
  Title
The genome of Xanthomonas campestris pv. campestris B100 and its use for the reconstruction of metabolic pathways involved in xanthan biosynthesis.
  Journal
J Biotechnol 134:33-45 (2008)
DOI:10.1016/j.jbiotec.2007.12.013
Reference
  Authors
Albermann C, Piepersberg W
  Title
Expression and identification of the RfbE protein from Vibrio cholerae O1 and its use for the enzymatic synthesis of GDP-D-perosamine.
  Journal
Glycobiology 11:655-61 (2001)
DOI:10.1093/glycob/11.8.655
Related
pathway
pdf00010  Glycolysis / Gluconeogenesis
pdf00040  Pentose and glucuronate interconversions
pdf00051  Fructose and mannose metabolism
pdf00052  Galactose metabolism
pdf00053  Ascorbate and aldarate metabolism
pdf00500  Starch and sucrose metabolism
pdf00550  Peptidoglycan biosynthesis
KO pathway
ko00520   
LinkDB

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