KEGG   PATHWAY: pfy00260
Entry
pfy00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Pestalotiopsis fici
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pfy00260  Glycine, serine and threonine metabolism
pfy00260

Module
pfy_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pfy00260]
pfy_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pfy00260]
pfy_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:pfy00260]
pfy_M00621  Glycine cleavage system [PATH:pfy00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pestalotiopsis fici [GN:pfy]
Gene
PFICI_07891  hypothetical protein [KO:K00928] [EC:2.7.2.4]
PFICI_10130  putative aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
PFICI_14172  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
PFICI_07293  Homoserine kinase [KO:K00872] [EC:2.7.1.39]
PFICI_09091  Threonine synthase [KO:K01733] [EC:4.2.3.1]
PFICI_01153  hypothetical protein [KO:K01620] [EC:4.1.2.48]
PFICI_12392  Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
PFICI_03095  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
PFICI_09412  hypothetical protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
PFICI_05538  hypothetical protein [KO:K15633] [EC:5.4.2.12]
PFICI_05208  hypothetical protein [KO:K15918] [EC:2.7.1.31]
PFICI_13974  hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PFICI_12099  D-3-phosphoglycerate dehydrogenase 1 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PFICI_00968  hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PFICI_11025  hypothetical protein [KO:K00831] [EC:2.6.1.52]
PFICI_02927  hypothetical protein [KO:K01079] [EC:3.1.3.3]
PFICI_05706  oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
PFICI_07874  oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
PFICI_04976  hypothetical protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
PFICI_02734  5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
PFICI_10776  hypothetical protein [KO:K00274] [EC:1.4.3.4]
PFICI_11143  hypothetical protein [KO:K00276] [EC:1.4.3.21]
PFICI_03360  hypothetical protein [KO:K00276] [EC:1.4.3.21]
PFICI_15236  Copper amine oxidase 1 [KO:K00276] [EC:1.4.3.21]
PFICI_02249  hypothetical protein [KO:K00276] [EC:1.4.3.21]
PFICI_07671  hypothetical protein [KO:K00276] [EC:1.4.3.21]
PFICI_04076  Copper amine oxidase 1 [KO:K00276] [EC:1.4.3.21]
PFICI_01492  hypothetical protein [KO:K00276] [EC:1.4.3.21]
PFICI_04018  hypothetical protein [KO:K00276] [EC:1.4.3.21]
PFICI_14866  hypothetical protein [KO:K00276] [EC:1.4.3.21]
PFICI_01727  hypothetical protein [KO:K00276] [EC:1.4.3.21]
PFICI_05874  hypothetical protein [KO:K00276] [EC:1.4.3.21]
PFICI_13767  hypothetical protein [KO:K00281] [EC:1.4.4.2]
PFICI_01503  hypothetical protein [KO:K00605] [EC:2.1.2.10]
PFICI_03506  Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
PFICI_04195  hypothetical protein [KO:K02437]
PFICI_09756  hypothetical protein [KO:K00273] [EC:1.4.3.3]
PFICI_11946  hypothetical protein [KO:K00273] [EC:1.4.3.3]
PFICI_03892  hypothetical protein [KO:K00273] [EC:1.4.3.3]
PFICI_02939  hypothetical protein [KO:K00273] [EC:1.4.3.3]
PFICI_08563  hypothetical protein [KO:K00273] [EC:1.4.3.3]
PFICI_04252  D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
PFICI_06261  hypothetical protein [KO:K00273] [EC:1.4.3.3]
PFICI_08522  hypothetical protein [KO:K00273] [EC:1.4.3.3]
PFICI_03532  CDP-alcohol phosphatidyltransferase class-I family protein [KO:K17103] [EC:2.7.8.8]
PFICI_07075  Betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
PFICI_10893  hypothetical protein [KO:K00309] [EC:1.5.3.10]
PFICI_13935  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
PFICI_03280  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
PFICI_09741  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
PFICI_02262  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
PFICI_02143  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
PFICI_10295  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
PFICI_11314  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
PFICI_03641  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
PFICI_03979  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
PFICI_13646  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
PFICI_00963  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
PFICI_03861  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
PFICI_07964  hypothetical protein [KO:K01697] [EC:4.2.1.22]
PFICI_01172  Cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
PFICI_13212  Threonine dehydratase [KO:K01754] [EC:4.3.1.19]
PFICI_07198  hypothetical protein [KO:K01754] [EC:4.3.1.19]
PFICI_12077  hypothetical protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
PFICI_10804  hypothetical protein [KO:K20498] [EC:4.3.1.18]
PFICI_06923  hypothetical protein [KO:K20498] [EC:4.3.1.18]
PFICI_08397  Tryptophan synthase [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pfy00010  Glycolysis / Gluconeogenesis
pfy00020  Citrate cycle (TCA cycle)
pfy00230  Purine metabolism
pfy00250  Alanine, aspartate and glutamate metabolism
pfy00270  Cysteine and methionine metabolism
pfy00290  Valine, leucine and isoleucine biosynthesis
pfy00300  Lysine biosynthesis
pfy00330  Arginine and proline metabolism
pfy00460  Cyanoamino acid metabolism
pfy00470  D-Amino acid metabolism
pfy00564  Glycerophospholipid metabolism
pfy00600  Sphingolipid metabolism
pfy00620  Pyruvate metabolism
pfy00630  Glyoxylate and dicarboxylate metabolism
pfy00640  Propanoate metabolism
pfy00680  Methane metabolism
pfy00860  Porphyrin metabolism
pfy00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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