KEGG   PATHWAY: pguu03040
Entry
pguu03040                   Pathway                                
Name
Spliceosome - Pterocles gutturalis (yellow-throated sandgrouse)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
pguu03040  Spliceosome
pguu03040

Other DBs
GO: 0005681
Organism
Pterocles gutturalis (yellow-throated sandgrouse) [GN:pguu]
Gene
104458692  DDX46; probable ATP-dependent RNA helicase DDX46 [KO:K12811] [EC:5.6.2.7]
104462373  DHX38; LOW QUALITY PROTEIN: pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
104461412  CDC40; pre-mRNA-processing factor 17 [KO:K12816]
104469109  PRPF18; pre-mRNA-splicing factor 18 [KO:K12817]
104460447  DHX8; ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
104457764  SLU7; pre-mRNA-splicing factor SLU7 [KO:K12819]
104459201  LOW QUALITY PROTEIN: putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [KO:K12820] [EC:5.6.2.6]
104459771  LOW QUALITY PROTEIN: small nuclear ribonucleoprotein-associated protein B'-like [KO:K11086]
104471663  SNRPD1; small nuclear ribonucleoprotein Sm D1 isoform X1 [KO:K11087]
104460855  SNRPD2; small nuclear ribonucleoprotein Sm D2 [KO:K11096]
104458467  SNRPG; small nuclear ribonucleoprotein G [KO:K11099]
104459348  SNRPC; U1 small nuclear ribonucleoprotein C [KO:K11095]
104458229  PRPF40A; pre-mRNA-processing factor 40 homolog A [KO:K12821]
104463891  RNA-binding protein 25-like [KO:K12822]
104469561  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
104464993  TCERG1; LOW QUALITY PROTEIN: transcription elongation regulator 1 [KO:K12824]
104457646  SNRPA1; U2 small nuclear ribonucleoprotein A' [KO:K11092]
104459271  U2 small nuclear ribonucleoprotein B'' [KO:K11094]
104462235  SF3A1; splicing factor 3A subunit 1 [KO:K12825]
104464553  LOW QUALITY PROTEIN: splicing factor 3A subunit 2-like [KO:K12826]
104467731  SF3A3; splicing factor 3A subunit 3 [KO:K12827]
104457476  SF3B1; splicing factor 3B subunit 1 [KO:K12828]
104471188  SF3B3; splicing factor 3B subunit 3 [KO:K12830]
104465441  SF3B6; splicing factor 3B subunit 6 [KO:K12833]
104462817  PHF5A; PHD finger-like domain-containing protein 5A [KO:K12834]
104469496  DDX42; LOW QUALITY PROTEIN: ATP-dependent RNA helicase DDX42 [KO:K12835] [EC:5.6.2.7]
104459901  splicing factor U2AF 35 kDa subunit-like [KO:K12836]
104462052  PUF60; poly(U)-binding-splicing factor PUF60 isoform X1 [KO:K12838]
104459322  SMNDC1; survival of motor neuron-related-splicing factor 30 [KO:K12839]
104458765  RBM17; splicing factor 45 [KO:K12840]
104458553  CHERP; calcium homeostasis endoplasmic reticulum protein [KO:K12841]
104458499  U2SURP; U2 snRNP-associated SURP motif-containing protein [KO:K12842]
104467485  RP9; retinitis pigmentosa 9 protein [KO:K19604]
104462974  LSM3; U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
104470491  LSM4; U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
104458184  LSM5; U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
104465319  LSM6; U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
104460211  LSM7; U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
104457869  PRPF3; U4/U6 small nuclear ribonucleoprotein Prp3 [KO:K12843]
104466474  PRPF4; U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
104458137  PPIH; peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
104460561  NHP2L1; NHP2-like protein 1 [KO:K12845]
104468484  PRPF38A; pre-mRNA-splicing factor 38A [KO:K12849]
104466183  PRPF38B; pre-mRNA-splicing factor 38B [KO:K12850]
104462265  EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
104464599  PRPF6; pre-mRNA-processing factor 6 [KO:K12855]
104467828  PRPF8; pre-mRNA-processing-splicing factor 8 [KO:K12856]
104469206  SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
104466242  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
104465279  CDC5L; cell division cycle 5-like protein [KO:K12860]
104458471  PLRG1; pleiotropic regulator 1 [KO:K12862]
104461234  CWC15; spliceosome-associated protein CWC15 homolog [KO:K12863]
104466315  CTNNBL1; beta-catenin-like protein 1 [KO:K12864]
104470036  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
104458480  SNW1; SNW domain-containing protein 1 [KO:K06063]
104461244  CRNKL1; crooked neck-like protein 1 [KO:K12869]
104460221  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
104469346  PPIE; peptidyl-prolyl cis-trans isomerase E [KO:K09564] [EC:5.2.1.8]
104470326  CCDC12; coiled-coil domain-containing protein 12 [KO:K12871]
104458644  RBM22; pre-mRNA-splicing factor RBM22 [KO:K12872]
104460256  BUD31; protein BUD31 homolog [KO:K12873]
104461161  AQR; LOW QUALITY PROTEIN: intron-binding protein aquarius [KO:K12874]
104469547  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
104459781  protein mago nashi homolog [KO:K12877]
104457955  THOC1; THO complex subunit 1 [KO:K12878]
104466761  THOC2; THO complex subunit 2 [KO:K12879]
104460814  THOC3; LOW QUALITY PROTEIN: THO complex subunit 3 [KO:K12880]
104467040  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
104462001  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
104467712  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 [KO:K12741]
104465300  RBMX; RNA-binding motif protein, X chromosome isoform X1 [KO:K12885]
104459694  HNRNPK; heterogeneous nuclear ribonucleoprotein K [KO:K12886]
104458756  HNRNPM; heterogeneous nuclear ribonucleoprotein M isoform X1 [KO:K12887]
104458675  HNRNPU; heterogeneous nuclear ribonucleoprotein U [KO:K12888]
104470281  LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 1-like [KO:K12890]
104459728  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
104460503  LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 6-like [KO:K12893]
104459273  serine/arginine-rich splicing factor 5-like isoform X1 [KO:K12893]
104459423  SRSF4; serine/arginine-rich splicing factor 4 [KO:K12893]
104470793  SRSF7; serine/arginine-rich splicing factor 7 [KO:K12896]
104463171  TRA2B; transformer-2 protein homolog beta isoform X1 [KO:K12897]
104460127  transformer-2 protein homolog alpha-like [KO:K12897]
104459970  SRSF10; serine/arginine-rich splicing factor 10 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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