KEGG   PATHWAY: pki03015
Entry
pki03015                    Pathway                                
Name
mRNA surveillance pathway - Paramormyrops kingsleyae
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
pki03015  mRNA surveillance pathway
pki03015

Other DBs
GO: 0071028
Organism
Paramormyrops kingsleyae [GN:pki]
Gene
111835500  ncbp1; nuclear cap-binding protein subunit 1 [KO:K12882]
111858788  ncbp2; nuclear cap-binding protein subunit 2 [KO:K12883]
111845674  regulator of nonsense transcripts 3A-like isoform X1 [KO:K14328]
111835026  upf3b; regulator of nonsense transcripts 3B [KO:K14328]
111838339  RNA-binding protein 8A-like [KO:K12876]
111853522  RNA-binding protein 8A isoform X1 [KO:K12876]
111847654  magoh; protein mago nashi homolog [KO:K12877]
111834942  protein mago nashi homolog [KO:K12877]
111856117  casc3; protein CASC3 [KO:K14323]
111836854  eif4a3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
111837616  sap18; histone deacetylase complex subunit SAP18 [KO:K14324]
111850958  pinin-like [KO:K13114]
111852638  pnn; pinin [KO:K13114]
111837706  apoptotic chromatin condensation inducer in the nucleus-like isoform X1 [KO:K12875]
111854537  acin1; apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
111860611  RNA-binding protein with serine-rich domain 1-like isoform X1 [KO:K14325]
111856761  RNA-binding protein with serine-rich domain 1-like [KO:K14325]
111832916  THO complex subunit 4-like [KO:K12881]
111843192  THO complex subunit 4-like [KO:K12881]
111855775  ATP-dependent RNA helicase DDX19A [KO:K18655] [EC:5.6.2.7]
111858772  gle1; nucleoporin GLE1 isoform X1 [KO:K18723]
111834735  nxf1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
111853544  nxt2; NTF2-related export protein 2 [KO:K14285]
111842831  spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
111855650  pym1; partner of Y14 and mago [KO:K14294]
111859635  srrm1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
111843049  rngtt; mRNA-capping enzyme [KO:K13917] [EC:2.7.7.50 3.6.1.74]
111852324  rnmt; mRNA cap guanine-N7 methyltransferase isoform X1 [KO:K00565] [EC:2.1.1.56]
111836826  fus; RNA-binding protein FUS [KO:K13098]
111834418  tardbp; TAR DNA-binding protein 43 [KO:K23600]
111857063  TAR DNA-binding protein 43-like [KO:K23600]
111835614  polyadenylate-binding protein 2-B-like isoform X1 [KO:K14396]
111832958  pabpn1l; embryonic polyadenylate-binding protein 2 isoform X1 [KO:K14396]
111840817  polyadenylate-binding protein 2-B-like isoform X1 [KO:K14396]
111851801  cleavage and polyadenylation specificity factor subunit 5 [KO:K14397]
111851802  cleavage and polyadenylation specificity factor subunit 5-like [KO:K14397]
111848099  cleavage and polyadenylation specificity factor subunit 5-like isoform X1 [KO:K14397]
111843115  cleavage and polyadenylation specificity factor subunit 6 isoform X1 [KO:K14398]
111851107  cpsf6; cleavage and polyadenylation specificity factor subunit 6 isoform X1 [KO:K14398]
111848014  cpsf7; cleavage and polyadenylation specificity factor subunit 7 [KO:K14398]
111850827  poly(A) polymerase type 3-like isoform X1 [KO:K14376] [EC:2.7.7.19]
111850942  poly(A) polymerase beta-like isoform X1 [KO:K14376] [EC:2.7.7.19]
111859451  poly(A) polymerase gamma-like isoform X1 [KO:K14376] [EC:2.7.7.19]
111834195  clp1; polyribonucleotide 5'-hydroxyl-kinase Clp1 [KO:K14399] [EC:2.7.1.78]
111838057  pcf11; pre-mRNA cleavage complex 2 protein Pcf11 isoform X1 [KO:K14400]
111843845  cpsf1; cleavage and polyadenylation specificity factor subunit 1 [KO:K14401]
111841213  cpsf2; cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
111851204  cpsf3; cleavage and polyadenylation specificity factor subunit 3 [KO:K14403] [EC:3.1.27.-]
111845534  cpsf4; cleavage and polyadenylation specificity factor subunit 4 isoform X1 [KO:K14404]
111850083  fip1l1; pre-mRNA 3'-end-processing factor FIP1 isoform X1 [KO:K14405]
111838062  pre-mRNA 3'-end-processing factor FIP1-like isoform X1 [KO:K14405]
111836677  wdr33; pre-mRNA 3' end processing protein WDR33 [KO:K15542]
111855851  wdr82; WD repeat-containing protein 82 [KO:K14962]
111840498  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
111842088  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
111849258  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
111842149  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
111850693  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
111855133  serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like isoform X1 [KO:K06269] [EC:3.1.3.16]
111855420  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
111853573  ssu72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 isoform X1 [KO:K15544] [EC:3.1.3.16]
111853924  RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like isoform X1 [KO:K15544] [EC:3.1.3.16]
111856957  cstf1; cleavage stimulation factor subunit 1 [KO:K14406]
111836508  cstf2; cleavage stimulation factor subunit 2 isoform X1 [KO:K14407]
111846511  cstf3; cleavage stimulation factor subunit 3 isoform X1 [KO:K14408]
111838044  sympk; symplekin [KO:K06100]
111842193  RNA-binding protein Musashi homolog 1 isoform X1 [KO:K14411]
111839147  msi1; RNA-binding protein Musashi homolog 1 isoform X1 [KO:K14411]
111856390  RNA-binding protein Musashi homolog 2-like [KO:K14411]
111860224  dazap1; DAZ-associated protein 1 isoform X1 [KO:K14411]
111860871  RNA-binding protein Musashi homolog 2 isoform X1 [KO:K14411]
111838525  RNA-binding protein Musashi homolog 2-like [KO:K14411]
111838769  pabpc4; polyadenylate-binding protein 4 [KO:K13126]
111844682  embryonic polyadenylate-binding protein-like isoform X1 [KO:K13126]
111845056  polyadenylate-binding protein 1-like [KO:K13126]
111848283  polyadenylate-binding protein 1 [KO:K13126]
111834690  eukaryotic peptide chain release factor subunit 1 [KO:K03265]
111859888  eukaryotic peptide chain release factor subunit 1-like [KO:K03265]
111848626  gspt1; eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1 [KO:K03267]
111849167  eukaryotic peptide chain release factor GTP-binding subunit ERF3A-like [KO:K03267]
111860382  upf1; regulator of nonsense transcripts 1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
111842367  upf2; regulator of nonsense transcripts 2 [KO:K14327]
111849179  smg1; serine/threonine-protein kinase SMG1 isoform X1 [KO:K08873] [EC:2.7.11.1]
111847554  smg7; protein SMG7 isoform X1 [KO:K14409]
111838480  smg5; protein SMG5 isoform X1 [KO:K11125]
111847162  telomerase-binding protein EST1A-like isoform X1 [KO:K11124] [EC:3.1.-.-]
111840281  telomerase-binding protein EST1A-like [KO:K11124] [EC:3.1.-.-]
111847940  ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
111835938  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
111839546  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like isoform X1 [KO:K04382] [EC:3.1.3.16]
111844798  ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
111836971  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like isoform X1 [KO:K04354]
111839410  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
111848522  ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
111836212  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform X1 [KO:K04354]
111860711  ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
111852641  ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
111853464  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha-like isoform X1 [KO:K11583]
111850492  ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
111838233  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta-like isoform X1 [KO:K11583]
111856266  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta-like isoform X1 [KO:K11583]
111851032  ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
111844407  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like isoform X1 [KO:K11584]
111839527  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform-like [KO:K11584]
111844459  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
111835246  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
111852440  ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
111849001  ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
111858036  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
111841198  hbs1l; HBS1-like protein isoform X1 [KO:K14416]
111833110  pelo; protein pelota homolog isoform X1 [KO:K06965]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
pki03013  Nucleocytoplasmic transport
pki03018  RNA degradation
pki03040  Spliceosome
KO pathway
ko03015   
LinkDB

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