KEGG   PATHWAY: plai00983
Entry
plai00983                   Pathway                                
Name
Drug metabolism - other enzymes - Poecilia latipinna (sailfin molly)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
plai00983  Drug metabolism - other enzymes
plai00983

Organism
Poecilia latipinna (sailfin molly) [GN:plai]
Gene
106936635  hypoxanthine-guanine phosphoribosyltransferase-like isoform X1 [KO:K00760] [EC:2.4.2.8]
106953941  hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
106958009  impdh1; inosine-5'-monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
106947419  impdh2; inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
106960117  inosine-5'-monophosphate dehydrogenase 1b isoform X1 [KO:K00088] [EC:1.1.1.205]
106935511  gmps; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
106957534  tpmt; thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
106950380  xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
106963721  itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
106940756  carboxylesterase 1E-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
106950510  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
106956939  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
106956941  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
106936028  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
106951412  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
106951413  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
106937158  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
106952965  UDP-glucuronosyltransferase 2A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
106952985  UDP-glucuronosyltransferase 2A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
106959622  ugt1a1; UDP-glucuronosyltransferase 1-1 isoform X1 [KO:K00699] [EC:2.4.1.17]
106964908  UDP-glucuronosyltransferase 1-1-like [KO:K00699] [EC:2.4.1.17]
106956648  gusb; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
106961763  tymp; thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
106951348  dpyd; dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
106962149  dpys; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
106934413  upb1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
106946914  upp2; uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
106939806  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
106941617  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
106936231  uridine-cytidine kinase 2-A-like [KO:K00876] [EC:2.7.1.48]
106952516  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
106954269  uck1; uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
106954308  uridine-cytidine kinase 2-B isoform X1 [KO:K00876] [EC:2.7.1.48]
106961012  uckl1; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
106951261  tk1; thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
106959551  tk2; thymidine kinase 2, mitochondrial [KO:K00857] [EC:2.7.1.21]
106948498  umps; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
106956399  cmpk1; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
106953358  ribonucleoside-diphosphate reductase large subunit-like isoform X1 [KO:K10807] [EC:1.17.4.1]
106939252  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
106956493  ribonucleoside-diphosphate reductase subunit M2 B-like [KO:K10808] [EC:1.17.4.1]
106958472  rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
106934529  nucleoside diphosphate kinase B-like [KO:K00940] [EC:2.7.4.6]
106935430  nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
106962672  nme7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
106957422  nme3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
106951632  nucleoside diphosphate kinase A-like isoform X1 [KO:K00940] [EC:2.7.4.6]
106964757  nucleoside diphosphate kinase B-like [KO:K00940] [EC:2.7.4.6]
106935172  dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial [KO:K01520] [EC:3.6.1.23]
106957721  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
106957722  arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like [KO:K00622] [EC:2.3.1.5]
106956339  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
106956340  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
106958357  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
106958358  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
106958359  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
106958360  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
106958361  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
106946564  glutathione S-transferase Mu 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
106946573  mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
106959037  mgst1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
106947676  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
106947677  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
106939997  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
106940751  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
106948398  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
106964577  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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