KEGG   PATHWAY: pmeg00260
Entry
pmeg00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Paraburkholderia megapolitana
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pmeg00260  Glycine, serine and threonine metabolism
pmeg00260

Module
pmeg_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pmeg00260]
pmeg_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pmeg00260]
pmeg_M00555  Betaine biosynthesis, choline => betaine [PATH:pmeg00260]
pmeg_M00621  Glycine cleavage system [PATH:pmeg00260]
pmeg_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:pmeg00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Paraburkholderia megapolitana [GN:pmeg]
Gene
FNZ07_24990  aspartate kinase [KO:K00928] [EC:2.7.2.4]
FNZ07_06105  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
FNZ07_22160  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
FNZ07_06420  homoserine kinase [KO:K02204] [EC:2.7.1.39]
FNZ07_22870  thrH; bifunctional phosphoserine phosphatase/homoserine phosphotransferase ThrH [KO:K02203] [EC:3.1.3.3 2.7.1.39]
FNZ07_22165  threonine synthase [KO:K01733] [EC:4.2.3.1]
FNZ07_02245  ltaE; low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
FNZ07_10350  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
FNZ07_16605  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
FNZ07_16715  alanine--glyoxylate aminotransferase family protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
FNZ07_05475  aminotransferase class V-fold PLP-dependent enzyme [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
FNZ07_09045  aminotransferase class V-fold PLP-dependent enzyme [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
FNZ07_02770  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
FNZ07_14865  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
FNZ07_24080  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
FNZ07_27610  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
FNZ07_22535  glycerate kinase [KO:K00865] [EC:2.7.1.165]
FNZ07_15260  gpmA; 2,3-diphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
FNZ07_16080  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
FNZ07_18355  hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FNZ07_29155  D-2-hydroxyacid dehydrogenase family protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FNZ07_13825  D-2-hydroxyacid dehydrogenase family protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FNZ07_23015  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
FNZ07_27995  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
FNZ07_30235  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
FNZ07_19565  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
FNZ07_22375  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
FNZ07_16600  ydfG; bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
FNZ07_04955  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
FNZ07_04960  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
FNZ07_33075  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
FNZ07_33065  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
FNZ07_21385  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
FNZ07_25420  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
FNZ07_33070  gcvH; glycine cleavage system protein GcvH [KO:K02437]
FNZ07_19715  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
FNZ07_10455  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
FNZ07_10310  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
FNZ07_10315  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
FNZ07_10385  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
FNZ07_10390  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
FNZ07_10365  NADH:flavin oxidoreductase [KO:K21833] [EC:1.5.7.3]
FNZ07_10370  DUF3483 domain-containing protein [KO:K21834]
FNZ07_10375  electron transfer flavoprotein subunit alpha/FixB family protein [KO:K25960]
FNZ07_10380  electron transfer flavoprotein subunit beta/FixA family protein [KO:K25961]
FNZ07_10090  sarcosine oxidase subunit alpha family protein [KO:K00302] [EC:1.5.3.24 1.5.3.1]
FNZ07_10080  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
FNZ07_10095  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
FNZ07_10085  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
FNZ07_33085  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
FNZ07_10075  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
FNZ07_22435  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
FNZ07_30600  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
FNZ07_05510  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
FNZ07_21170  pyridoxal-phosphate dependent enzyme [KO:K17989] [EC:4.3.1.17 4.3.1.19]
FNZ07_15770  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
FNZ07_25535  aspartate/glutamate racemase family protein [KO:K25316] [EC:5.1.1.10]
FNZ07_06135  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
FNZ07_06125  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
FNZ07_19525  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
FNZ07_22635  aminotransferase class III-fold pyridoxal phosphate-dependent enzyme [KO:K00836] [EC:2.6.1.76]
FNZ07_19545  ectoine synthase [KO:K06720] [EC:4.2.1.108]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pmeg00010  Glycolysis / Gluconeogenesis
pmeg00020  Citrate cycle (TCA cycle)
pmeg00230  Purine metabolism
pmeg00250  Alanine, aspartate and glutamate metabolism
pmeg00270  Cysteine and methionine metabolism
pmeg00290  Valine, leucine and isoleucine biosynthesis
pmeg00300  Lysine biosynthesis
pmeg00330  Arginine and proline metabolism
pmeg00460  Cyanoamino acid metabolism
pmeg00470  D-Amino acid metabolism
pmeg00564  Glycerophospholipid metabolism
pmeg00600  Sphingolipid metabolism
pmeg00620  Pyruvate metabolism
pmeg00630  Glyoxylate and dicarboxylate metabolism
pmeg00640  Propanoate metabolism
pmeg00680  Methane metabolism
pmeg00860  Porphyrin metabolism
pmeg00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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