KEGG   PATHWAY: pmeg00230
Entry
pmeg00230                   Pathway                                
Name
Purine metabolism - Paraburkholderia megapolitana
Class
Metabolism; Nucleotide metabolism
Pathway map
pmeg00230  Purine metabolism
pmeg00230

Module
pmeg_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:pmeg00230]
pmeg_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:pmeg00230]
pmeg_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:pmeg00230]
pmeg_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:pmeg00230]
pmeg_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:pmeg00230]
pmeg_M00546  Purine degradation, xanthine => urea [PATH:pmeg00230]
pmeg_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:pmeg00230]
pmeg_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:pmeg00230]
Other DBs
GO: 0006163 0042278
Organism
Paraburkholderia megapolitana [GN:pmeg]
Gene
FNZ07_19855  NUDIX hydrolase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
FNZ07_17310  phosphopentomutase [KO:K01839] [EC:5.4.2.7]
FNZ07_18395  phosphomannomutase/phosphoglucomutase [KO:K15778] [EC:5.4.2.8 5.4.2.2]
FNZ07_15540  ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
FNZ07_06205  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
FNZ07_19455  purD; phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
FNZ07_19325  purT; formate-dependent phosphoribosylglycinamide formyltransferase [KO:K08289] [EC:6.3.1.21]
FNZ07_22700  purL; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
FNZ07_12960  phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
FNZ07_16415  purM; phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
FNZ07_29955  5-(carboxyamino)imidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
FNZ07_29960  purE; 5-(carboxyamino)imidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
FNZ07_29965  phosphoribosylaminoimidazolesuccinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
FNZ07_15990  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
FNZ07_16105  purH; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
FNZ07_15635  adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
FNZ07_30605  5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
FNZ07_22280  surE; 5'/3'-nucleotidase SurE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
FNZ07_22320  pgeF; peptidoglycan editing factor PgeF [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
FNZ07_10215  nucleoside hydrolase [KO:K01239] [EC:3.2.2.1]
FNZ07_17155  nucleoside hydrolase [KO:K01239] [EC:3.2.2.1]
FNZ07_30730  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
FNZ07_24605  guaB; IMP dehydrogenase [KO:K00088] [EC:1.1.1.205]
FNZ07_25185  nucleoside-diphosphate kinase [KO:K00940] [EC:2.7.4.6]
FNZ07_28380  rdgB; RdgB/HAM1 family non-canonical purine NTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
FNZ07_16805  xdhA; xanthine dehydrogenase small subunit [KO:K13481] [EC:1.17.1.4]
FNZ07_28125  xdhA; xanthine dehydrogenase small subunit [KO:K13481] [EC:1.17.1.4]
FNZ07_16810  xdhB; xanthine dehydrogenase molybdopterin binding subunit [KO:K13482] [EC:1.17.1.4]
FNZ07_28130  xdhB; xanthine dehydrogenase molybdopterin binding subunit [KO:K13482] [EC:1.17.1.4]
FNZ07_08560  xanthine dehydrogenase family protein molybdopterin-binding subunit [KO:K11177] [EC:1.17.1.4]
FNZ07_08935  xanthine dehydrogenase family protein molybdopterin-binding subunit [KO:K11177] [EC:1.17.1.4]
FNZ07_08565  xanthine dehydrogenase family protein subunit M [KO:K11178] [EC:1.17.1.4]
FNZ07_08930  xanthine dehydrogenase family protein subunit M [KO:K11178] [EC:1.17.1.4]
FNZ07_08570  2Fe-2S iron-sulfur cluster binding domain-containing protein [KO:K13483]
FNZ07_08925  (2Fe-2S)-binding protein [KO:K13483]
FNZ07_24595  guaA; glutamine-hydrolyzing GMP synthase [KO:K01951] [EC:6.3.5.2]
FNZ07_33325  glutamine amidotransferase [KO:K01951] [EC:6.3.5.2]
FNZ07_28145  guaD; guanine deaminase [KO:K01487] [EC:3.5.4.3]
FNZ07_28365  guanylate kinase [KO:K00942] [EC:2.7.4.8]
FNZ07_30705  ribonucleoside-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
FNZ07_10340  adenosylcobalamin-dependent ribonucleoside-diphosphate reductase [KO:K00525] [EC:1.17.4.1]
FNZ07_30700  ribonucleotide-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
FNZ07_31575  deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
FNZ07_27130  bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
FNZ07_28355  bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
FNZ07_26375  ppx; exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
FNZ07_26795  bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [KO:K00951] [EC:2.7.6.5]
FNZ07_17900  hypothetical protein [KO:K01768] [EC:4.6.1.1]
FNZ07_25775  CHASE2 domain-containing protein [KO:K01768] [EC:4.6.1.1]
FNZ07_25115  adenylosuccinate synthase [KO:K01939] [EC:6.3.4.4]
FNZ07_30680  carbohydrate kinase family protein [KO:K00856] [EC:2.7.1.20]
FNZ07_06430  AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
FNZ07_28140  adenosine deaminase [KO:K21053] [EC:3.5.4.2]
FNZ07_29615  adenylate kinase [KO:K00939] [EC:2.7.4.3]
FNZ07_26125  phosphodiesterase [KO:K03651] [EC:3.1.4.53]
FNZ07_18115  symmetrical bis(5'-nucleosyl)-tetraphosphatase [KO:K01525] [EC:3.6.1.41]
FNZ07_18055  cysC; adenylyl-sulfate kinase [KO:K00860] [EC:2.7.1.25]
FNZ07_06710  adenylyl-sulfate kinase [KO:K00860] [EC:2.7.1.25]
FNZ07_18580  sulfate adenylyltransferase [KO:K00956] [EC:2.7.7.4]
FNZ07_18575  cysD; sulfate adenylyltransferase subunit CysD [KO:K00957] [EC:2.7.7.4]
FNZ07_12290  NAD(P)/FAD-dependent oxidoreductase [KO:K22879] [EC:1.14.13.113]
FNZ07_24310  uraH; hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
FNZ07_24350  uraD; 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
FNZ07_24355  puuE; allantoinase PuuE [KO:K16842] [EC:3.5.2.5]
FNZ07_24345  alc; allantoicase [KO:K01477] [EC:3.5.3.4]
FNZ07_24340  ureidoglycolate lyase [KO:K01483] [EC:4.3.2.3]
FNZ07_05775  fumarylacetoacetate hydrolase family protein [KO:K16856] [EC:4.3.2.3]
FNZ07_18440  ureC; urease subunit alpha [KO:K01428] [EC:3.5.1.5]
FNZ07_18445  urease subunit beta [KO:K01429] [EC:3.5.1.5]
FNZ07_18450  ureA; urease subunit gamma [KO:K01430] [EC:3.5.1.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
pmeg00030  Pentose phosphate pathway
pmeg00220  Arginine biosynthesis
pmeg00250  Alanine, aspartate and glutamate metabolism
pmeg00260  Glycine, serine and threonine metabolism
pmeg00340  Histidine metabolism
pmeg00630  Glyoxylate and dicarboxylate metabolism
pmeg00730  Thiamine metabolism
pmeg00740  Riboflavin metabolism
pmeg00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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