KEGG   PATHWAY: pmei00983
Entry
pmei00983                   Pathway                                
Name
Drug metabolism - other enzymes - Poecilia mexicana (shortfin molly)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
pmei00983  Drug metabolism - other enzymes
pmei00983

Organism
Poecilia mexicana (shortfin molly) [GN:pmei]
Gene
106917721  hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
106926598  hypoxanthine-guanine phosphoribosyltransferase-like isoform X1 [KO:K00760] [EC:2.4.2.8]
106906359  impdh1; inosine-5'-monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
106918883  inosine-5'-monophosphate dehydrogenase 1b isoform X1 [KO:K00088] [EC:1.1.1.205]
106933523  impdh2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
106928682  gmps; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
106927634  tpmt; thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
106910105  xdh; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
106921007  itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
106927557  carboxylesterase 1E-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
106904862  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
106915931  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
106915932  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
106932353  UDP-glucuronosyltransferase 1-1-like [KO:K00699] [EC:2.4.1.17]
106932645  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
106933535  UDP-glucuronosyltransferase 2A2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
106922147  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
106922148  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
106922669  UDP-glucuronosyltransferase 2A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
106922670  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
106922672  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
106929663  UDP-glucuronosyltransferase-like [KO:K00699] [EC:2.4.1.17]
106931022  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
106931023  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
106931024  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
106911592  gusb; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
106917310  tymp; thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
106917803  dpyd; dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
106919942  dpys; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
106930510  upb1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
106906612  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
106923750  upp2; uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
106915909  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
106917234  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
106928212  uridine-cytidine kinase 2-A-like [KO:K00876] [EC:2.7.1.48]
106923847  uck1; uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
106924578  uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
106930839  uridine-cytidine kinase 2-B isoform X1 [KO:K00876] [EC:2.7.1.48]
106920216  tk2; thymidine kinase 2, mitochondrial [KO:K00857] [EC:2.7.1.21]
106917538  tk1; thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
106917214  umps; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
106929850  cmpk1; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
106920178  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
106922180  ribonucleoside-diphosphate reductase large subunit-like isoform X1 [KO:K10807] [EC:1.17.4.1]
106914452  ribonucleoside-diphosphate reductase subunit M2 B-like [KO:K10808] [EC:1.17.4.1]
106925336  rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
106920018  nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
106914739  nme7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
106907055  nucleoside diphosphate kinase A-like isoform X1 [KO:K00940] [EC:2.7.4.6]
106918744  nucleoside diphosphate kinase B-like [KO:K00940] [EC:2.7.4.6]
106927218  nucleoside diphosphate kinase B-like [KO:K00940] [EC:2.7.4.6]
106934113  nme3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
106931198  nucleoside diphosphate kinase A-like isoform X1 [KO:K00940] [EC:2.7.4.6]
106903743  dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial [KO:K01520] [EC:3.6.1.23]
106927342  nat1; arylamine N-acetyltransferase 1 isoform X1 [KO:K00622] [EC:2.3.1.5]
106912438  mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
106914796  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
106907371  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
106907374  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
106907378  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
106908119  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
106908120  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
106916298  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
106910153  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
106918210  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
106918524  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
106918525  glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
106926861  mgst1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
106922836  mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
106923139  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
106923141  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
106923142  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
106923143  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
106923144  glutathione S-transferase A-like isoform X1 [KO:K00799] [EC:2.5.1.18]
106923145  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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