KEGG   PATHWAY: pnc00260
Entry
pnc00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas aeruginosa NCGM2.S1
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pnc00260  Glycine, serine and threonine metabolism
pnc00260

Module
pnc_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pnc00260]
pnc_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pnc00260]
pnc_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:pnc00260]
pnc_M00555  Betaine biosynthesis, choline => betaine [PATH:pnc00260]
pnc_M00621  Glycine cleavage system [PATH:pnc00260]
pnc_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:pnc00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas aeruginosa NCGM2.S1 [GN:pnc]
Gene
NCGM2_1682  lysC; aspartate kinase [KO:K00928] [EC:2.7.2.4]
NCGM2_4240  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
NCGM2_4868  hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
NCGM2_6274  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
NCGM2_2657  thrH; phosphoserine phosphatase [KO:K02203] [EC:3.1.3.3 2.7.1.39]
NCGM2_4867  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
NCGM2_1680  hypothetical protein [KO:K01620] [EC:4.1.2.48]
NCGM2_6186  ltaA; low specificity l-threonine aldolase [KO:K01620] [EC:4.1.2.48]
NCGM2_0990  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
NCGM2_3450  glyA2; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
NCGM2_6188  glyA2; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
NCGM2_0963  hprA; glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
NCGM2_5086  putative 2-hydroxyacid dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
NCGM2_1913  hypothetical protein [KO:K00865] [EC:2.7.1.165]
NCGM2_2384  ttuD; hypothetical protein [KO:K11529] [EC:2.7.1.165]
NCGM2_0378  pgm; phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
NCGM2_0292  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
NCGM2_4278  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
NCGM2_0559  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
NCGM2_5776  hypothetical protein [KO:K00274] [EC:1.4.3.4]
NCGM2_3451  gcvP2; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
NCGM2_5973  gcvP1; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
NCGM2_3448  gcvT2; glycine cleavage system protein T2 [KO:K00605] [EC:2.1.2.10]
NCGM2_5975  gcvT; glycine cleavage system aminomethyltransferase T [KO:K00605] [EC:2.1.2.10]
NCGM2_0700  lpd3; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
NCGM2_3259  lpdV; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
NCGM2_2478  lpdG; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
NCGM2_3452  gcvH2; glycine cleavage system protein H [KO:K02437]
NCGM2_4343  hypothetical protein [KO:K02437]
NCGM2_5974  gcvH1; glycine cleavage system protein H [KO:K02437]
NCGM2_0736  hypothetical protein [KO:K02437]
NCGM2_0886  pssA; phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
NCGM2_6144  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
NCGM2_6145  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
NCGM2_3708  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
NCGM2_6183  putative ring hydroxylating dioxygenase alpha-subunit [KO:K00479] [EC:1.14.13.251]
NCGM2_6184  putative ferredoxin [KO:K21832] [EC:1.14.13.251]
NCGM2_6171  putative FMN oxidoreductase [KO:K21833] [EC:1.5.7.3]
NCGM2_6172  putative ferredoxin [KO:K21834]
NCGM2_6173  etfA-1; putative electron transfer flavoprotein alpha subunit [KO:K25960]
NCGM2_6174  etfB-1; hypothetical protein [KO:K25961]
NCGM2_6191  soxA; sarcosine oxidase alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
NCGM2_6189  soxB; sarcosine oxidase beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
NCGM2_6192  soxG; sarcosine oxidase gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
NCGM2_6190  soxD; sarcosine oxidase delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]
NCGM2_5799  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
NCGM2_5798  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
NCGM2_3449  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
NCGM2_6153  sdaB; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
NCGM2_1625  hypothetical protein [KO:K01754] [EC:4.3.1.19]
NCGM2_2213  ilvA2; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
NCGM2_5873  ilvA1; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
NCGM2_4488  dsdA; D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
NCGM2_0035  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
NCGM2_0036  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
NCGM2_3418  pvdH; diaminobutyrate-2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
NCGM2_3212  diaminobutyrate-2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pnc00010  Glycolysis / Gluconeogenesis
pnc00020  Citrate cycle (TCA cycle)
pnc00230  Purine metabolism
pnc00250  Alanine, aspartate and glutamate metabolism
pnc00270  Cysteine and methionine metabolism
pnc00290  Valine, leucine and isoleucine biosynthesis
pnc00300  Lysine biosynthesis
pnc00330  Arginine and proline metabolism
pnc00460  Cyanoamino acid metabolism
pnc00470  D-Amino acid metabolism
pnc00564  Glycerophospholipid metabolism
pnc00600  Sphingolipid metabolism
pnc00620  Pyruvate metabolism
pnc00630  Glyoxylate and dicarboxylate metabolism
pnc00640  Propanoate metabolism
pnc00680  Methane metabolism
pnc00860  Porphyrin metabolism
pnc00920  Sulfur metabolism
KO pathway
ko00260   
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