KEGG   PATHWAY: ppoi04144
Entry
ppoi04144                   Pathway                                
Name
Endocytosis - Pollicipes pollicipes (gooseneck barnacle)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
ppoi04144  Endocytosis
ppoi04144

Other DBs
GO: 0006897
Organism
Pollicipes pollicipes (gooseneck barnacle) [GN:ppoi]
Gene
119099232  ADP-ribosylation factor 6-like [KO:K07941]
119099379  ADP-ribosylation factor 6-like [KO:K07941]
119091161  ADP-ribosylation factor 6 [KO:K07941]
119091166  ADP-ribosylation factor 6 [KO:K07941]
119092879  ADP-ribosylation factor 6 [KO:K07941]
119096625  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha-like [KO:K00889] [EC:2.7.1.68]
119112034  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
119107080  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
119107176  phospholipase D2-like isoform X1 [KO:K01115] [EC:3.1.4.4]
119108253  LOW QUALITY PROTEIN: phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
119107517  dynamin-like [KO:K01528] [EC:3.6.5.5]
119091750  dynamin-like [KO:K01528] [EC:3.6.5.5]
119091751  dynamin-like [KO:K01528] [EC:3.6.5.5]
119111038  clathrin heavy chain 1-like isoform X1 [KO:K04646]
119111751  clathrin heavy chain 1-like isoform X1 [KO:K04646]
119107256  LOW QUALITY PROTEIN: AP-2 complex subunit alpha-like [KO:K11824]
119096401  AP-2 complex subunit mu [KO:K11826]
119090580  TGF-beta receptor type-1-like isoform X1 [KO:K04674] [EC:2.7.11.30]
119098469  mothers against decapentaplegic homolog 3-like [KO:K23605]
119110158  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
119093004  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
119089528  fibroblast growth factor receptor 1-like isoform X1 [KO:K05093] [EC:2.7.10.1]
119090471  fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
119102666  E3 ubiquitin-protein ligase CBL-B-B-like [KO:K04707] [EC:2.3.2.27]
119102748  E3 ubiquitin-protein ligase CBL-B-B-like [KO:K04707] [EC:2.3.2.27]
119100736  endophilin-A-like isoform X1 [KO:K11247]
119102567  endophilin-A-like isoform X1 [KO:K11247]
119090649  myc box-dependent-interacting protein 1-like isoform X1 [KO:K12562]
119114039  epsin-1-like [KO:K12471]
119108275  epidermal growth factor receptor substrate 15-like 1 [KO:K12472]
119108051  spartin-like [KO:K19366]
119097001  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase NEDD4-like [KO:K10591] [EC:2.3.2.26]
119108952  E3 ubiquitin-protein ligase Nedd-4-like isoform X1 [KO:K10591] [EC:2.3.2.26]
119107386  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
119090371  E3 ubiquitin-protein ligase NRDP1-like [KO:K11981] [EC:2.3.2.27]
119110620  E3 ubiquitin-protein ligase NRDP1-like [KO:K11981] [EC:2.3.2.27]
119110709  E3 ubiquitin-protein ligase NRDP1-like isoform X1 [KO:K11981] [EC:2.3.2.27]
119095278  E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:2.3.2.26]
119095280  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase SMURF1-like [KO:K04678] [EC:2.3.2.26]
119105721  E3 ubiquitin-protein ligase Su(dx)-like [KO:K05633] [EC:2.3.2.26]
119111891  LOW QUALITY PROTEIN: G protein-coupled receptor kinase 1-like [KO:K00910] [EC:2.7.11.15]
119112879  G protein-coupled receptor kinase 1-like [KO:K00910] [EC:2.7.11.15]
119099347  G protein-coupled receptor kinase 2-like [KO:K08291] [EC:2.7.11.16]
119096357  beta-arrestin-1-like [KO:K04439]
119099630  phosrestin-2-like [KO:K04439]
119099631  arrestin homolog [KO:K04439]
119100587  arrestin, lateral eye-like [KO:K04439]
119099897  actin-related protein 2 [KO:K17260]
119098420  LOW QUALITY PROTEIN: actin-related protein 3-like [KO:K18584]
119099296  LOW QUALITY PROTEIN: actin-related protein 3-like [KO:K18584]
119098526  LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
119098698  actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
119110295  actin-related protein 2/3 complex subunit 2-like [KO:K05758]
119099434  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
119089503  actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
119089507  actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
119093120  actin-related protein 2/3 complex subunit 5-C-like [KO:K05754]
119114337  heat shock 70 kDa protein cognate 4-like [KO:K03283]
119111926  heat shock protein 68-like [KO:K03283]
119103385  heat shock protein 70 B2-like [KO:K03283]
119113063  heat shock protein 68-like [KO:K03283]
119113064  heat shock protein 68-like [KO:K03283]
119113065  heat shock protein 68-like [KO:K03283]
119094859  heat shock 70 kDa protein cognate 4 [KO:K03283]
119094322  WASH complex subunit 4-like [KO:K18465]
119105500  LOW QUALITY PROTEIN: WASH complex subunit 5-like [KO:K18464]
119105501  WASH complex subunit 5-like [KO:K18464]
119091398  WASH complex subunit 3-like isoform X1 [KO:K18463]
119091933  F-actin-capping protein subunit alpha-like [KO:K10364]
119110568  F-actin-capping protein subunit beta [KO:K10365]
119111871  vacuolar protein sorting-associated protein 29-like [KO:K18467]
119112119  LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 29-like [KO:K18467]
119090455  vacuolar protein sorting-associated protein 26B-like [KO:K18466]
119111114  vacuolar protein sorting-associated protein 26B-like [KO:K18466]
119111115  di-N-acetylchitobiase-like [KO:K18466]
119089444  vacuolar protein sorting-associated protein 35-like [KO:K18468]
119089811  LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 35-like [KO:K18468]
119101475  sorting nexin-12-like [KO:K17918]
119097253  ubiquitin carboxyl-terminal hydrolase 8-like [KO:K11839] [EC:3.4.19.12]
119104418  STAM-binding protein-like A [KO:K11866] [EC:3.4.19.12]
119104741  STAM-binding protein-like A [KO:K11866] [EC:3.4.19.12]
119112252  ras-related protein Rab-7a-like [KO:K07897]
119094974  hepatocyte growth factor-regulated tyrosine kinase substrate-like [KO:K12182]
119094981  hepatocyte growth factor-regulated tyrosine kinase substrate-like [KO:K12182]
119100792  signal transducing adapter molecule 1-like isoform X1 [KO:K04705]
119107620  tumor susceptibility gene 101 protein-like [KO:K12183]
119107621  tumor susceptibility gene 101 protein-like [KO:K12183]
119101103  multivesicular body subunit 12B-like [KO:K12186]
119101105  multivesicular body subunit 12B-like [KO:K12186]
119090401  vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
119091557  vacuolar protein sorting-associated protein 37A-like [KO:K12185]
119112463  vacuolar protein sorting-associated protein 37B-like [KO:K12185]
119101486  vacuolar-sorting protein SNF8-like [KO:K12188]
119101702  LOW QUALITY PROTEIN: vacuolar-sorting protein SNF8-like [KO:K12188]
119098757  vacuolar protein-sorting-associated protein 36-like [KO:K12190]
119099356  vacuolar protein-sorting-associated protein 25-like [KO:K12189]
119095475  LOW QUALITY PROTEIN: charged multivesicular body protein 6-A-like [KO:K12195]
119114932  charged multivesicular body protein 4b-like [KO:K12194]
119112068  charged multivesicular body protein 3-like [KO:K12193]
119112932  charged multivesicular body protein 3-like [KO:K12193]
119107797  LOW QUALITY PROTEIN: charged multivesicular body protein 2a-like [KO:K12191]
119094607  charged multivesicular body protein 2b-like [KO:K12192]
119112576  charged multivesicular body protein 7-like isoform X1 [KO:K15053]
119100658  vacuolar protein sorting-associated protein 4-like [KO:K12196]
119093431  vacuolar protein sorting-associated protein 4A-like [KO:K12196]
119093600  vacuolar protein sorting-associated protein 4A-like [KO:K12196]
119101971  vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
119102826  vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
119103274  vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
119105975  charged multivesicular body protein 1a-like [KO:K12197]
119106266  charged multivesicular body protein 1a-like [KO:K12197]
119109192  charged multivesicular body protein 1b-like [KO:K12197]
119098744  LOW QUALITY PROTEIN: charged multivesicular body protein 5-like [KO:K12198]
119114482  IST1 homolog [KO:K19476]
119110518  IST1 homolog [KO:K19476]
119110692  IST1 homolog [KO:K19476]
119093154  programmed cell death 6-interacting protein-like [KO:K12200]
119100958  maspardin-like [KO:K19367]
119108495  sorting nexin-2-like isoform X1 [KO:K17917]
119092921  sorting nexin-32-like [KO:K17920]
119092985  sorting nexin-32-like [KO:K17920]
119102442  sorting nexin-32-like isoform X1 [KO:K17920]
119093275  sorting nexin-6-like isoform X1 [KO:K17920]
119098460  tyrosine-protein kinase Src64B-like isoform X1 [KO:K05704] [EC:2.7.10.2]
119098693  tyrosine-protein kinase Src64B-like isoform X1 [KO:K05704] [EC:2.7.10.2]
119096712  rho-related GTP-binding protein RhoA-A-like [KO:K04513]
119107669  ras-like GTP-binding protein Rho1 [KO:K04513]
119091742  ras-like GTP-binding protein Rho1 [KO:K04513]
119110223  folate receptor beta-like [KO:K13649]
119091806  caveolin-3-like [KO:K06278]
119098909  caveolin-3-like [KO:K12959]
119099191  caveolin-3-like [KO:K12959]
119114903  ras-related protein Rab-5B-like [KO:K07888]
119095179  ras-related protein Rab5A-like [KO:K07889]
119111288  rab GTPase-binding effector protein 1-like [KO:K12480]
119111289  rab GTPase-binding effector protein 2-like [KO:K12480]
119104772  RUN and FYVE domain-containing protein 2-like [KO:K12482]
119104773  RUN and FYVE domain-containing protein 2-like [KO:K12482]
119104774  RUN and FYVE domain-containing protein 2-like [KO:K12482]
119105686  EH domain-containing protein 3-like [KO:K12483]
119104969  EH domain-containing protein 3-like [KO:K12483]
119103437  vacuolar protein sorting-associated protein 45-like [KO:K12479]
119114670  sorting nexin-4-like [KO:K17919]
119101936  sorting nexin-4-like [KO:K17919]
119112759  sorting nexin-4-like [KO:K17919]
119105794  ras-related protein Rab-10-like [KO:K07903]
119094818  ras-related protein Rab-10-like [KO:K07903]
119094819  ras-related protein Rab-10-like [KO:K07903]
119111039  ras-related protein Rab-8A-like [KO:K07901]
119111041  LOW QUALITY PROTEIN: ras-related protein Rab-8A-like [KO:K07901]
119112342  ras-related protein Rab-35-like [KO:K07876]
119109184  ras-related protein Rab-11A-like [KO:K07904]
119109185  ras-related protein Rab-11A-like isoform X1 [KO:K07904]
119109186  ras-related protein Rab-11A-like isoform X1 [KO:K07904]
119105756  kinesin heavy chain-like [KO:K10396]
119095816  rab11 family-interacting protein 4-like [KO:K12485]
119095835  rab11 family-interacting protein 4-like [KO:K12485]
119114280  rab11 family-interacting protein 4B-like isoform X1 [KO:K12485]
119113762  rab11 family-interacting protein 4B-like [KO:K12485]
119109747  LOW QUALITY PROTEIN: partitioning defective 3 homolog [KO:K04237]
119109750  partitioning defective 3 homolog B-like [KO:K04237]
119104129  partitioning defective 3 homolog [KO:K04237]
119104149  LOW QUALITY PROTEIN: partitioning defective 3 homolog B-like [KO:K04237]
119105739  partitioning defective 6 homolog gamma-like [KO:K06093]
119106273  partitioning defective 6 homolog gamma-like [KO:K06093]
119096312  atypical protein kinase C-like isoform X1 [KO:K06069] [EC:2.7.11.13]
119105826  cdc42 homolog isoform X1 [KO:K04393]
119114812  cdc42 homolog [KO:K04393]
119096645  stromal membrane-associated protein 1-like [KO:K12486]
119097247  stromal membrane-associated protein 1-like [KO:K12486]
119109715  ARF GTPase-activating protein GIT2-like [KO:K12487]
119100269  arfGAP with SH3 domain, ANK repeat and PH domain-containing protein-like [KO:K12488]
119098252  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like [KO:K12489]
119098265  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like [KO:K12489]
119111829  centaurin-gamma-1A-like [KO:K12491]
119091333  ADP-ribosylation factor GTPase-activating protein 2-like [KO:K12493]
119099969  PH and SEC7 domain-containing protein-like [KO:K12494]
119111686  IQ motif and SEC7 domain-containing protein 2-like [KO:K12495]
119113746  cytohesin-1-like [KO:K18441]
119089991  brefeldin A-inhibited guanine nucleotide-exchange protein 1-like [KO:K18442]
119089994  brefeldin A-inhibited guanine nucleotide-exchange protein 2-like [KO:K18442]
119089999  brefeldin A-inhibited guanine nucleotide-exchange protein 2-like [KO:K18442]
119114891  LOW QUALITY PROTEIN: Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1-like [KO:K18443]
119095134  LOW QUALITY PROTEIN: Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1-like [KO:K18443]
119096420  ADP-ribosylation factor 1 [KO:K07937]
119105750  ADP-ribosylation factor 4-like [KO:K07939]
119100887  ADP-ribosylation factor 5-like [KO:K07939]
119112166  ADP-ribosylation factor 4 [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
ppoi04070  Phosphatidylinositol signaling system
ppoi04130  SNARE interactions in vesicular transport
ppoi04142  Lysosome
ppoi04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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