KEGG   PATHWAY: ppsy02020
Entry
ppsy02020                   Pathway                                
Name
Two-component system - Pseudomonas versuta
Description
Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor protein-histidine kinase (HK) and a response regulator (RR). In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signal(s) in the environment. Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR. The activated RR can then effect changes in cellular physiology, often by regulating gene expression. Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription.
Class
Environmental Information Processing; Signal transduction
Pathway map
ppsy02020  Two-component system
ppsy02020

Other DBs
GO: 0000160
Organism
Pseudomonas versuta [GN:ppsy]
Gene
AOC04_21150  histidine kinase [KO:K07636] [EC:2.7.13.3]
AOC04_21155  phosphate regulon transcriptional regulatory protein PhoB [KO:K07657]
AOC04_19890  phosphate-binding protein [KO:K02040]
AOC04_13500  hypothetical protein [KO:K02040]
AOC04_02500  histidine kinase [KO:K07637] [EC:2.7.13.3]
AOC04_02495  transcriptional regulator [KO:K07660]
AOC04_18910  ATPase [KO:K07638] [EC:2.7.13.3]
AOC04_18915  chemotaxis protein CheY [KO:K07659]
AOC04_12870  chemotaxis protein CheY [KO:K07662]
AOC04_14850  serine peptidase [KO:K04771] [EC:3.4.21.107]
AOC04_05880  secretion protein HlyD [KO:K07799]
AOC04_05885  multidrug transporter [KO:K07788]
AOC04_05890  acriflavine resistance protein B [KO:K07789]
AOC04_01055  histidine kinase [KO:K07644] [EC:2.7.13.3]
AOC04_03850  ATPase [KO:K07644] [EC:2.7.13.3]
AOC04_19205  histidine kinase [KO:K07644] [EC:2.7.13.3]
AOC04_01060  transcriptional regulator [KO:K07665]
AOC04_03855  transcriptional regulator [KO:K07665]
AOC04_19200  transcriptional regulator [KO:K07665]
AOC04_05195  histidine kinase [KO:K07645] [EC:2.7.13.3]
AOC04_05190  transcriptional regulator [KO:K07666]
AOC04_12750  hypothetical protein [KO:K02406]
AOC04_12595  fliA; flagellar biosynthesis sigma factor [KO:K02405]
AOC04_18150  flagellar motor protein MotA [KO:K02556]
AOC04_12570  motC; flagellar motor protein [KO:K02556]
AOC04_04145  histidine kinase [KO:K07646] [EC:2.7.13.3]
AOC04_04150  transcriptional regulator [KO:K07667]
AOC04_04130  ATPase [KO:K01546]
AOC04_04135  potassium-transporting ATPase subunit B [KO:K01547] [EC:7.2.2.6]
AOC04_04140  ATPase [KO:K01548]
AOC04_14895  histidine kinase [KO:K07649] [EC:2.7.13.3]
AOC04_14900  transcriptional regulator [KO:K07774]
AOC04_14915  tripartite tricarboxylate transporter TctA [KO:K07793]
AOC04_09620  hypothetical protein [KO:K07793]
AOC04_14910  hypothetical protein [KO:K07794]
AOC04_20860  cytochrome B [KO:K02259] [EC:1.17.99.9]
AOC04_20230  chromosomal replication initiation protein [KO:K02313]
AOC04_02245  hypothetical protein [KO:K14205] [EC:2.3.2.3]
AOC04_08710  porin [KO:K18093] [EC:3.4.21.-]
AOC04_13960  porin [KO:K18093] [EC:3.4.21.-]
AOC04_02575  histidine kinase [KO:K19609] [EC:2.7.13.3]
AOC04_02570  transcriptional regulator [KO:K19610]
AOC04_10270  outer membrane receptor protein [KO:K19611]
AOC04_19615  chemotaxis protein CheY [KO:K08083]
AOC04_15730  GDP-mannose dehydrogenase [KO:K00066] [EC:1.1.1.132]
AOC04_14225  hypothetical protein [KO:K07783]
AOC04_16425  histidine kinase [KO:K07677] [EC:2.7.13.3]
AOC04_16475  histidine kinase [KO:K07677] [EC:2.7.13.3]
AOC04_16460  LuxR family transcriptional regulator [KO:K07687]
AOC04_16465  LuxR family transcriptional regulator [KO:K07687]
AOC04_04020  LuxR family transcriptional regulator [KO:K07687]
AOC04_04040  LuxR family transcriptional regulator [KO:K07687]
AOC04_04045  LuxR family transcriptional regulator [KO:K07687]
AOC04_02565  chemotaxis protein CheY [KO:K07678] [EC:2.7.13.3]
AOC04_06550  chemotaxis protein CheY [KO:K07689]
AOC04_07275  carbon storage regulator CsrA [KO:K03563]
AOC04_10840  carbon storage regulator CsrA [KO:K03563]
AOC04_14420  carbon storage regulator [KO:K03563]
AOC04_03640  histidine kinase [KO:K07679] [EC:2.7.13.3]
AOC04_04030  sensor protein evgS [KO:K07679] [EC:2.7.13.3]
AOC04_04035  sensor protein evgS [KO:K07679] [EC:2.7.13.3]
AOC04_01810  LuxR family transcriptional regulator [KO:K07690]
AOC04_03645  LuxR family transcriptional regulator [KO:K07690]
AOC04_04095  ampC; class C beta-lactamase [KO:K01467] [EC:3.5.2.6]
AOC04_17520  histidine kinase [KO:K27076] [EC:2.7.13.3]
AOC04_17535  LuxR family transcriptional regulator [KO:K27077]
AOC04_16440  fimbrial protein [KO:K07347]
AOC04_17580  hypothetical protein [KO:K02651]
AOC04_17575  pilus assembly protein CpaB [KO:K02279]
AOC04_17570  secretin [KO:K02280]
AOC04_17565  pilus assembly protein [KO:K02282]
AOC04_17560  ATPase [KO:K02283] [EC:7.4.2.8]
AOC04_17555  type II secretion system protein F [KO:K12510]
AOC04_17550  type II secretion system protein F [KO:K12511]
AOC04_17545  hypothetical protein [KO:K27079]
AOC04_17515  hypothetical protein [KO:K27080]
AOC04_15165  glnD; protein-PII uridylyltransferase [KO:K00990] [EC:2.7.7.59]
AOC04_18990  histidine kinase [KO:K07708] [EC:2.7.13.3]
AOC04_18995  glnG; nitrogen regulation protein NR(I) [KO:K07712]
AOC04_07750  gamma-glutamylputrescine synthetase [KO:K01915] [EC:6.3.1.2]
AOC04_04085  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
AOC04_21195  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
AOC04_21205  gamma-glutamylputrescine synthetase [KO:K01915] [EC:6.3.1.2]
AOC04_17115  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
AOC04_14210  glutamate--ammonia ligase [KO:K01915] [EC:6.3.1.2]
AOC04_18980  glnA; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
AOC04_16695  Fis family transcriptional regulator [KO:K07713]
AOC04_16490  Short chain fatty acid transporter [KO:K02106]
AOC04_06375  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
AOC04_06395  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
AOC04_06510  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
AOC04_10100  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
AOC04_17480  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
AOC04_16730  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
AOC04_02485  cytochrome C biogenesis protein CcmE [KO:K10125] [EC:2.7.13.3]
AOC04_19275  ATPase [KO:K10125] [EC:2.7.13.3]
AOC04_02480  C4-dicarboxylate ABC transporter [KO:K10126]
AOC04_19280  Fis family transcriptional regulator [KO:K10126]
AOC04_02505  C4-dicarboxylate transporter [KO:K11103]
AOC04_16115  RNA polymerase sigma-54 factor [KO:K03092]
AOC04_20970  histidine kinase [KO:K11383] [EC:2.7.13.3]
AOC04_20975  chemotaxis protein CheY [KO:K11384]
AOC04_08135  chemotaxis protein CheR [KO:K00575] [EC:2.1.1.80]
AOC04_14175  chemotaxis protein [KO:K00575] [EC:2.1.1.80]
AOC04_12085  chemotaxis protein [KO:K13924] [EC:2.1.1.80 3.1.1.61]
AOC04_09365  chemotaxis protein [KO:K03406]
AOC04_02905  chemotaxis protein [KO:K03406]
AOC04_17215  chemotaxis protein [KO:K03406]
AOC04_13270  chemotaxis protein [KO:K03406]
AOC04_18785  chemotaxis protein [KO:K03406]
AOC04_14615  pili assembly chaperone [KO:K03406]
AOC04_19725  chemotaxis protein [KO:K03406]
AOC04_05110  chemotaxis protein [KO:K03776]
AOC04_12550  chemotaxis protein CheW [KO:K03408]
AOC04_12555  chemotaxis protein CheW [KO:K03408]
AOC04_12580  chemotaxis protein CheA [KO:K03407] [EC:2.7.13.3]
AOC04_12590  histidine kinase [KO:K03413]
AOC04_08140  chemotaxis protein CheB [KO:K03412] [EC:3.1.1.61 3.5.1.44]
AOC04_12575  chemotaxis protein CheY [KO:K03412] [EC:3.1.1.61 3.5.1.44]
AOC04_01090  chemotaxis protein CheW [KO:K03415]
AOC04_03715  chemotaxis protein CheW [KO:K03415]
AOC04_14180  chemotaxis protein CheW [KO:K03415]
AOC04_21685  chemotaxis protein [KO:K02660]
AOC04_21680  protein PilI [KO:K02659]
AOC04_21670  pilus assembly protein PilG [KO:K02657]
AOC04_21675  chemotaxis protein CheY [KO:K02658]
AOC04_21695  chemotaxis protein [KO:K06598]
AOC04_15355  chemotaxis protein CheR [KO:K13486]
AOC04_15365  chemotaxis protein [KO:K13487]
AOC04_15360  chemotaxis protein CheW [KO:K13488]
AOC04_15350  chemotaxis protein CheW [KO:K13489]
AOC04_15345  chemotaxis protein CheA [KO:K13490]
AOC04_15340  chemotaxis protein CheY [KO:K13491] [EC:3.1.1.61]
AOC04_15335  diguanylate cyclase [KO:K11444] [EC:2.7.7.65]
AOC04_19140  histidine kinase [KO:K11354] [EC:2.7.13.3]
AOC04_08150  chemotaxis protein CheY [KO:K13589]
AOC04_12725  AAA family ATPase [KO:K10941]
AOC04_12720  histidine kinase [KO:K10942] [EC:2.7.13.3]
AOC04_12715  Fis family transcriptional regulator [KO:K10943]
AOC04_01715  histidine kinase [KO:K17060] [EC:2.7.13.3]
AOC04_01710  Fis family transcriptional regulator [KO:K17061]
AOC04_01720  amino acid ABC transporter ATP-binding protein [KO:K10004] [EC:7.4.2.1]
AOC04_01725  amino acid ABC transporter permease [KO:K10002]
AOC04_01730  amino acid ABC transporter permease [KO:K10003]
AOC04_01735  ABC transporter [KO:K10001]
AOC04_11755  glutaminase [KO:K05597] [EC:3.5.1.38]
AOC04_22480  cyclic AMP receptor protein [KO:K10914]
AOC04_00525  glutaminase [KO:K01425] [EC:3.5.1.2]
AOC04_00745  histidine kinase [KO:K15011] [EC:2.7.13.3]
AOC04_00750  chemotaxis protein CheY [KO:K15012]
AOC04_00910  ubiquinol-cytochrome c reductase iron-sulfur subunit [KO:K00411] [EC:7.1.1.8]
AOC04_00915  cytochrome B [KO:K00412]
AOC04_00920  cytochrome C [KO:K00413]
AOC04_01230  cytochrome C [KO:K08738]
AOC04_05855  cytochrome C oxidase Cbb3 [KO:K00404] [EC:7.1.1.9]
AOC04_05080  cytochrome C oxidase Cbb3 [KO:K00404] [EC:7.1.1.9]
AOC04_05100  cytochrome C oxidase Cbb3 [KO:K00404] [EC:7.1.1.9]
AOC04_05075  cytochrome C oxidase Cbb3 [KO:K00405]
AOC04_05095  cytochrome C oxidase Cbb3 [KO:K00405]
AOC04_05070  cytochrome oxidase [KO:K00407]
AOC04_05090  cytochrome oxidase [KO:K00407]
AOC04_05065  cytochrome C oxidase Cbb3 [KO:K00406]
AOC04_05085  cytochrome C oxidase Cbb3 [KO:K00406]
AOC04_00250  cytochrome D ubiquinol oxidase subunit I [KO:K00425] [EC:7.1.1.7]
AOC04_00255  ubiquinol oxidase subunit II [KO:K00426] [EC:7.1.1.7]
AOC04_18240  channel protein TolC [KO:K12340]
AOC04_09765  capsular biosynthesis protein [KO:K01991]
AOC04_09720  phosphotyrosine protein phosphatase [KO:K25307] [EC:3.1.3.48]
AOC04_03075  protein tyrosine phosphatase [KO:K25307] [EC:3.1.3.48]
AOC04_09725  tyrosine protein kinase [KO:K16692] [EC:2.7.10.3]
AOC04_09730  UDP-N-acetylglucosamine 2-epimerase [KO:K01791] [EC:5.1.3.14]
AOC04_09735  UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase [KO:K02472] [EC:1.1.1.336]
AOC04_22140  RNA polymerase subunit sigma [KO:K23514]
AOC04_05825  RNA polymerase subunit sigma [KO:K23514]
AOC04_02805  RNA polymerase subunit sigma [KO:K23514]
AOC04_10155  iron dicitrate transport regulator FecR [KO:K07165]
AOC04_10505  peptide ABC transporter substrate-binding protein [KO:K07165]
AOC04_14765  glycerol-3-phosphate ABC transporter substrate-binding protein [KO:K07165]
AOC04_13455  peptide ABC transporter substrate-binding protein [KO:K07165]
AOC04_22135  amino acid ABC transporter substrate-binding protein [KO:K07165]
AOC04_14090  iron dicitrate transport regulator FecR [KO:K07165]
AOC04_15860  sugar ABC transporter substrate-binding protein [KO:K07165]
AOC04_05830  amino acid ABC transporter substrate-binding protein [KO:K07165]
AOC04_02800  histidine kinase [KO:K07165]
AOC04_03620  histidine kinase [KO:K20973] [EC:2.7.13.3]
AOC04_13235  histidine kinase [KO:K20974] [EC:2.7.13.3]
AOC04_12670  histidine kinase [KO:K20976]
AOC04_12675  chemotaxis protein CheY [KO:K20977]
AOC04_12680  anti-anti-sigma factor [KO:K20978]
AOC04_14190  flagellar biosynthesis protein FlgM [KO:K02398]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00034  Manganese
C00036  Oxaloacetate
C00038  Zinc cation
C00042  Succinate
C00049  L-Aspartate
C00064  L-Glutamine
C00070  Copper
C00088  Nitrite
C00092  D-Glucose 6-phosphate
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00164  Acetoacetate
C00237  CO
C00238  Potassium cation
C00244  Nitrate
C00282  Hydrogen
C00291  Nickel
C00305  Magnesium cation
C00399  Ubiquinone
C00533  Nitric oxide
C00547  L-Noradrenaline
C00697  Nitrogen
C00788  L-Adrenaline
C00828  Menaquinone
C01019  L-Fucose
C01104  Trimethylamine N-oxide
C01667  Bacitracin
C02084  Tetrathionate
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05818  2-Demethylmenaquinone
C06230  Fe-enterobactin
C06689  Vancomycin
C06696  Lead
C11612  Polymyxin B
C11842  N-(3-(S)-Hydroxybutyryl)homoserine lactone
C11849  3-Hydroxy-palmitic acid methyl ester
C12008  Ramoplanin A2
C13768  Colistin sulfate
C14819  Fe3+
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C16665  12-Methyltetradecanoic acid
C18206  cis-11-Methyl-2-dodecenoic acid
C21220  AIP-1
C21221  CSP
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21245  AgrD1 peptide
D07746  Colistin (INN)
D08401  Polymyxin B (INN)
Reference
  Authors
Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A.
  Title
Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
  Journal
J Biol Chem 280:1448-56 (2005)
DOI:10.1074/jbc.M410104200
Reference
  Authors
Abdel-Fattah WR, Chen Y, Eldakak A, Hulett FM.
  Title
Bacillus subtilis phosphorylated PhoP: direct activation of the E(sigma)A- and repression of the E(sigma)E-responsive phoB-PS+V promoters during pho response.
  Journal
J Bacteriol 187:5166-78 (2005)
DOI:10.1128/JB.187.15.5166-5178.2005
Reference
  Authors
Navarre WW, Halsey TA, Walthers D, Frye J, McClelland M, Potter JL, Kenney LJ, Gunn JS, Fang FC, Libby SJ.
  Title
Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.
  Journal
Mol Microbiol 56:492-508 (2005)
DOI:10.1111/j.1365-2958.2005.04553.x
Reference
  Authors
Cai SJ, Inouye M.
  Title
EnvZ-OmpR interaction and osmoregulation in Escherichia coli.
  Journal
J Biol Chem 277:24155-61 (2002)
DOI:10.1074/jbc.M110715200
Reference
  Authors
Batchelor E, Walthers D, Kenney LJ, Goulian M.
  Title
The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.
  Journal
J Bacteriol 187:5723-31 (2005)
DOI:10.1128/JB.187.16.5723-5731.2005
Reference
  Authors
Nagakubo S, Nishino K, Hirata T, Yamaguchi A.
  Title
The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.
  Journal
J Bacteriol 184:4161-7 (2002)
DOI:10.1128/JB.184.15.4161-4167.2002
Reference
  Authors
Hagiwara D, Yamashino T, Mizuno T.
  Title
A Genome-wide view of the Escherichia coli BasS-BasR two-component system implicated in iron-responses.
  Journal
Biosci Biotechnol Biochem 68:1758-67 (2004)
DOI:10.1271/bbb.68.1758
Reference
  Authors
Munson GP, Lam DL, Outten FW, O'Halloran TV.
  Title
Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12.
  Journal
J Bacteriol 182:5864-71 (2000)
DOI:10.1128/JB.182.20.5864-5871.2000
Reference
  Authors
Sperandio V, Torres AG, Kaper JB.
  Title
Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli.
  Journal
Mol Microbiol 43:809-21 (2002)
DOI:10.1046/j.1365-2958.2002.02803.x
Reference
  Authors
Epstein W.
  Title
The roles and regulation of potassium in bacteria.
  Journal
Prog Nucleic Acid Res Mol Biol 75:293-320 (2003)
DOI:10.1016/S0079-6603(03)75008-9
Reference
  Authors
Ansaldi M, Simon G, Lepelletier M, Mejean V.
  Title
The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli.
  Journal
J Bacteriol 182:961-6 (2000)
DOI:10.1128/JB.182.4.961-966.2000
Reference
  Authors
Malpica R, Franco B, Rodriguez C, Kwon O, Georgellis D.
  Title
Identification of a quinone-sensitive redox switch in the ArcB sensor kinase.
  Journal
Proc Natl Acad Sci U S A 101:13318-23 (2004)
DOI:10.1073/pnas.0403064101
Reference
PMID:2666399
  Authors
Widenhorn KA, Somers JM, Kay WW.
  Title
Genetic regulation of the tricarboxylate transport operon (tctI) of Salmonella typhimurium.
  Journal
J Bacteriol 171:4436-41 (1989)
DOI:10.1128/JB.171.8.4436-4441.1989
Reference
  Authors
Hyyrylainen HL, Bolhuis A, Darmon E, Muukkonen L, Koski P, Vitikainen M, Sarvas M, Pragai Z, Bron S, van Dijl JM, Kontinen VP.
  Title
A novel two-component regulatory system in Bacillus subtilis for the survival of severe secretion stress.
  Journal
Mol Microbiol 41:1159-72 (2001)
DOI:10.1046/j.1365-2958.2001.02576.x
Reference
  Authors
Zhang X, Hulett FM.
  Title
ResD signal transduction regulator of aerobic respiration in Bacillus subtilis: ctaA promoter regulation.
  Journal
Mol Microbiol 37:1208-19 (2000)
DOI:10.1046/j.1365-2958.2000.02076.x
Reference
  Authors
Senadheera MD, Guggenheim B, Spatafora GA, Huang YC, Choi J, Hung DC, Treglown JS, Goodman SD, Ellen RP, Cvitkovitch DG.
  Title
A VicRK signal transduction system in Streptococcus mutans affects gtfBCD, gbpB, and ftf expression, biofilm formation, and genetic competence development.
  Journal
J Bacteriol 187:4064-76 (2005)
DOI:10.1128/JB.187.12.4064-4076.2005
Reference
  Authors
He H, Zahrt TC.
  Title
Identification and characterization of a regulatory sequence recognized by Mycobacterium tuberculosis persistence regulator MprA.
  Journal
J Bacteriol 187:202-12 (2005)
DOI:10.1128/JB.187.1.202-212.2005
Reference
  Authors
Hutchings MI
  Title
Unusual two-component signal transduction pathways in the actinobacteria.
  Journal
Adv Appl Microbiol 61:1-26 (2007)
DOI:10.1016/S0065-2164(06)61001-0
Reference
  Authors
Kramer R
  Title
Osmosensing and osmosignaling in Corynebacterium glutamicum.
  Journal
Amino Acids 37:487-97 (2009)
DOI:10.1007/s00726-009-0271-6
Reference
PMID:7751278
  Authors
Eraso JM, Kaplan S.
  Title
Oxygen-insensitive synthesis of the photosynthetic membranes of Rhodobacter sphaeroides: a mutant histidine kinase.
  Journal
J Bacteriol 177:2695-706 (1995)
DOI:10.1128/JB.177.10.2695-2706.1995
Reference
  Authors
Haydel SE, Dunlap NE, Benjamin WH Jr.
  Title
In vitro evidence of two-component system phosphorylation between the Mycobacterium tuberculosis TrcR/TrcS proteins.
  Journal
Microb Pathog 26:195-206 (1999)
DOI:10.1006/mpat.1998.0265
Reference
  Authors
Quisel JD, Burkholder WF, Grossman AD.
  Title
In vivo effects of sporulation kinases on mutant Spo0A proteins in Bacillus subtilis.
  Journal
J Bacteriol 183:6573-8 (2001)
DOI:10.1128/JB.183.22.6573-6578.2001
Reference
  Authors
Kaspar S, Bott M.
  Title
The sensor kinase CitA (DpiB) of Escherichia coli functions as a high-affinity citrate receptor.
  Journal
Arch Microbiol 177:313-21 (2002)
DOI:10.1007/s00203-001-0393-z
Reference
  Authors
Janausch IG, Garcia-Moreno I, Unden G.
  Title
Function of DcuS from Escherichia coli as a fumarate-stimulated histidine protein kinase in vitro.
  Journal
J Biol Chem 277:39809-14 (2002)
DOI:10.1074/jbc.M204482200
Reference
PMID:8550490
  Authors
Brunskill EW, Bayles KW.
  Title
Identification and molecular characterization of a putative regulatory locus that affects autolysis in Staphylococcus aureus.
  Journal
J Bacteriol 178:611-8 (1996)
DOI:10.1128/JB.178.3.611-618.1996
Reference
  Authors
Fujimoto DF, Brunskill EW, Bayles KW.
  Title
Analysis of genetic elements controlling Staphylococcus aureus lrgAB expression: potential role of DNA topology in SarA regulation.
  Journal
J Bacteriol 182:4822-8 (2000)
DOI:10.1128/JB.182.17.4822-4828.2000
Reference
  Authors
Dufour P, Jarraud S, Vandenesch F, Greenland T, Novick RP, Bes M, Etienne J, Lina G.
  Title
High genetic variability of the agr locus in Staphylococcus species.
  Journal
J Bacteriol 184:1180-6 (2002)
DOI:10.1128/JB.184.4.1180-1186.2002
Reference
PMID:8501030
  Authors
Rabin RS, Stewart V.
  Title
Dual response regulators (NarL and NarP) interact with dual sensors (NarX and NarQ) to control nitrate- and nitrite-regulated gene expression in Escherichia coli K-12.
  Journal
J Bacteriol 175:3259-68 (1993)
DOI:10.1128/JB.175.11.3259-3268.1993
Reference
PMID:9220011
  Authors
Chiang RC, Cavicchioli R, Gunsalus RP.
  Title
'Locked-on' and 'locked-off' signal transduction mutations in the periplasmic domain of the Escherichia coli NarQ and NarX sensors affect nitrate- and nitrite-dependent regulation by NarL and NarP.
  Journal
Mol Microbiol 24:1049-60 (1997)
DOI:10.1046/j.1365-2958.1997.4131779.x
Reference
  Authors
Verhamme DT, Postma PW, Crielaard W, Hellingwerf KJ.
  Title
Cooperativity in signal transfer through the Uhp system of Escherichia coli.
  Journal
J Bacteriol 184:4205-10 (2002)
DOI:10.1128/JB.184.15.4205-4210.2002
Reference
  Authors
Hagiwara D, Sugiura M, Oshima T, Mori H, Aiba H, Yamashino T, Mizuno T.
  Title
Genome-wide analyses revealing a signaling network of the RcsC-YojN-RcsB phosphorelay system in Escherichia coli.
  Journal
J Bacteriol 185:5735-46 (2003)
DOI:10.1128/JB.185.19.5735-5746.2003
Reference
  Authors
Hirakawa H, Nishino K, Yamada J, Hirata T, Yamaguchi A.
  Title
Beta-lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli.
  Journal
J Antimicrob Chemother 52:576-82 (2003)
DOI:10.1093/jac/dkg406
Reference
  Authors
Suzuki K, Wang X, Weilbacher T, Pernestig AK, Melefors O, Georgellis D, Babitzke P, Romeo T.
  Title
Regulatory circuitry of the CsrA/CsrB and BarA/UvrY systems of Escherichia coli.
  Journal
J Bacteriol 184:5130-40 (2002)
DOI:10.1128/JB.184.18.5130-5140.2002
Reference
  Authors
Kato A, Ohnishi H, Yamamoto K, Furuta E, Tanabe H, Utsumi R.
  Title
Transcription of emrKY is regulated by the EvgA-EvgS two-component system in Escherichia coli K-12.
  Journal
Biosci Biotechnol Biochem 64:1203-9 (2000)
DOI:10.1271/bbb.64.1203
Reference
  Authors
Ansaldi M, Dubnau D.
  Title
Diversifying selection at the Bacillus quorum-sensing locus and determinants of modification specificity during synthesis of the ComX pheromone.
  Journal
J Bacteriol 186:15-21 (2004)
DOI:10.1128/JB.186.1.15-21.2004
Reference
  Authors
Gabdrakhmanova L, Vishniakov I, Sharipova M, Balaban N, Kostrov S, Leshchinskaya I.
  Title
Salt stress induction of glutamyl endopeptidase biosynthesis in Bacillus intermedius.
  Journal
Microbiol Res 160:233-42 (2005)
DOI:10.1016/j.micres.2004.05.005
Reference
  Authors
Aguilar PS, Hernandez-Arriaga AM, Cybulski LE, Erazo AC, de Mendoza D.
  Title
Molecular basis of thermosensing: a two-component signal transduction thermometer in Bacillus subtilis.
  Journal
EMBO J 20:1681-91 (2001)
DOI:10.1093/emboj/20.7.1681
Reference
  Authors
Kuroda M, Kuroda H, Oshima T, Takeuchi F, Mori H, Hiramatsu K.
  Title
Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus.
  Journal
Mol Microbiol 49:807-21 (2003)
DOI:10.1046/j.1365-2958.2003.03599.x
Reference
  Authors
Saini DK, Malhotra V, Dey D, Pant N, Das TK, Tyagi JS.
  Title
DevR-DevS is a bona fide two-component system of Mycobacterium tuberculosis that is hypoxia-responsive in the absence of the DNA-binding domain of DevR.
  Journal
Microbiology 150:865-75 (2004)
DOI:10.1099/mic.0.26218-0
Reference
  Authors
Fedtke I, Kamps A, Krismer B, Gotz F.
  Title
The nitrate reductase and nitrite reductase operons and the narT gene of Staphylococcus carnosus are positively controlled by the novel two-component system NreBC.
  Journal
J Bacteriol 184:6624-34 (2002)
DOI:10.1128/JB.184.23.6624-6634.2002
Reference
PMID:8416895
  Authors
Shiau SP, Chen P, Reitzer LJ.
  Title
Effects of insertions and deletions in glnG (ntrC) of Escherichia coli on nitrogen regulator I-dependent DNA binding and transcriptional activation.
  Journal
J Bacteriol 175:190-9 (1993)
DOI:10.1128/JB.175.1.190-199.1993
Reference
  Authors
Leonhartsberger S, Huber A, Lottspeich F, Bock A.
  Title
The hydH/G Genes from Escherichia coli code for a zinc and lead responsive two-component regulatory system.
  Journal
J Mol Biol 307:93-105 (2001)
DOI:10.1006/jmbi.2000.4451
Reference
  Authors
Lioliou EE, Kyriakidis DA.
  Title
The role of bacterial antizyme: From an inhibitory protein to AtoC transcriptional regulator.
  Journal
Microb Cell Fact 3:8 (2004)
DOI:10.1186/1475-2859-3-8
Reference
  Authors
Yamamoto K, Ishihama A
  Title
Transcriptional response of Escherichia coli to external copper.
  Journal
Mol Microbiol 56:215-27 (2005)
DOI:10.1111/j.1365-2958.2005.04532.x
Reference
  Authors
Ashby MK, Mullineaux CW
  Title
Cyanobacterial ycf27 gene products regulate energy transfer from phycobilisomes to photosystems I and II.
  Journal
FEMS Microbiol Lett 181:253-60 (1999)
DOI:10.1111/j.1574-6968.1999.tb08852.x
Reference
  Authors
Lopez-Maury L, Garcia-Dominguez M, Florencio FJ, Reyes JC
  Title
A two-component signal transduction system involved in nickel sensing in the cyanobacterium Synechocystis sp. PCC 6803.
  Journal
Mol Microbiol 43:247-56 (2002)
DOI:10.1046/j.1365-2958.2002.02741.x
Reference
  Authors
Glover RT, Kriakov J, Garforth SJ, Baughn AD, Jacobs WR Jr
  Title
The two-component regulatory system senX3-regX3 regulates phosphate-dependent gene expression in Mycobacterium smegmatis.
  Journal
J Bacteriol 189:5495-503 (2007)
DOI:10.1128/JB.00190-07
Reference
  Authors
Hsiao HY, He Q, Van Waasbergen LG, Grossman AR
  Title
Control of photosynthetic and high-light-responsive genes by the histidine kinase DspA: negative and positive regulation and interactions between signal transduction pathways.
  Journal
J Bacteriol 186:3882-8 (2004)
DOI:10.1128/JB.186.12.3882-3888.2004
Reference
  Authors
Mutsuda M, Michel KP, Zhang X, Montgomery BL, Golden SS
  Title
Biochemical properties of CikA, an unusual phytochrome-like histidine protein kinase that resets the circadian clock in Synechococcus elongatus PCC 7942.
  Journal
J Biol Chem 278:19102-10 (2003)
DOI:10.1074/jbc.M213255200
Reference
PMID:9278513
  Authors
Yeh KC, Wu SH, Murphy JT, Lagarias JC
  Title
A cyanobacterial phytochrome two-component light sensory system.
  Journal
Science 277:1505-8 (1997)
DOI:10.1126/science.277.5331.1505
Reference
PMID:7635815
  Authors
Niu S, Jiang SQ, Hong J
  Title
Salmonella typhimurium pgtB mutants conferring constitutive expression of phosphoglycerate transporter pgtP independent of pgtC.
  Journal
J Bacteriol 177:4297-302 (1995)
DOI:10.1128/JB.177.15.4297-4302.1995
Reference
  Authors
Takai N, Nakajima M, Oyama T, Kito R, Sugita C, Sugita M, Kondo T, Iwasaki H
  Title
A KaiC-associating SasA-RpaA two-component regulatory system as a major circadian timing mediator in cyanobacteria.
  Journal
Proc Natl Acad Sci U S A 103:12109-14 (2006)
DOI:10.1073/pnas.0602955103
Reference
  Authors
Janausch IG, Zientz E, Tran QH, Kroger A, Unden G
  Title
C4-dicarboxylate carriers and sensors in bacteria.
  Journal
Biochim Biophys Acta 1553:39-56 (2002)
DOI:10.1016/S0005-2728(01)00233-X
Reference
  Authors
Zhou YF, Nan B, Nan J, Ma Q, Panjikar S, Liang YH, Wang Y, Su XD
  Title
C4-dicarboxylates sensing mechanism revealed by the crystal structures of DctB sensor domain.
  Journal
J Mol Biol 383:49-61 (2008)
DOI:10.1016/j.jmb.2008.08.010
Reference
  Authors
Novick RP, Jiang D
  Title
The staphylococcal saeRS system coordinates environmental signals with agr quorum sensing.
  Journal
Microbiology 149:2709-17 (2003)
DOI:10.1099/mic.0.26575-0
Reference
  Authors
Leech AJ, Sprinkle A, Wood L, Wozniak DJ, Ohman DE
  Title
The NtrC family regulator AlgB, which controls alginate biosynthesis in mucoid Pseudomonas aeruginosa, binds directly to the algD promoter.
  Journal
J Bacteriol 190:581-9 (2008)
DOI:10.1128/JB.01307-07
Reference
  Authors
Paul R, Jaeger T, Abel S, Wiederkehr I, Folcher M, Biondi EG, Laub MT, Jenal U
  Title
Allosteric regulation of histidine kinases by their cognate response regulator determines cell fate.
  Journal
Cell 133:452-61 (2008)
DOI:10.1016/j.cell.2008.02.045
Reference
  Authors
Whitchurch CB, Leech AJ, Young MD, Kennedy D, Sargent JL, Bertrand JJ, Semmler AB, Mellick AS, Martin PR, Alm RA, Hobbs M, Beatson SA, Huang B, Nguyen L, Commolli JC, Engel JN, Darzins A, Mattick JS.
  Title
Characterization of a complex chemosensory signal transduction system which controls twitching motility in Pseudomonas aeruginosa.
  Journal
Mol Microbiol 52:873-93 (2004)
DOI:10.1111/j.1365-2958.2004.04026.x
Reference
  Authors
Yoshihara S, Ikeuchi M.
  Title
Phototactic motility in the unicellular cyanobacterium Synechocystis sp. PCC 6803.
  Journal
Photochem Photobiol Sci 3:512-8 (2004)
DOI:10.1039/b402320j
Reference
  Authors
Ogawa T, Bao DH, Katoh H, Shibata M, Pakrasi HB, Bhattacharyya-Pakrasi M
  Title
A two-component signal transduction pathway regulates manganese homeostasis in Synechocystis 6803, a photosynthetic organism.
  Journal
J Biol Chem 277:28981-6 (2002)
DOI:10.1074/jbc.M204175200
Reference
  Authors
Yamaguchi K, Suzuki I, Yamamoto H, Lyukevich A, Bodrova I, Los DA, Piven I, Zinchenko V, Kanehisa M, Murata N
  Title
A two-component Mn2+-sensing system negatively regulates expression of the mntCAB operon in Synechocystis.
  Journal
Plant Cell 14:2901-13 (2002)
DOI:10.1105/tpc.006262
Reference
  Authors
Mascher T, Zimmer SL, Smith TA, Helmann JD
  Title
Antibiotic-inducible promoter regulated by the cell envelope stress-sensing two-component system LiaRS of Bacillus subtilis.
  Journal
Antimicrob Agents Chemother 48:2888-96 (2004)
DOI:10.1128/AAC.48.8.2888-2896.2004
Reference
  Authors
Hyyrylainen HL, Sarvas M, Kontinen VP
  Title
Transcriptome analysis of the secretion stress response of Bacillus subtilis.
  Journal
Appl Microbiol Biotechnol 67:389-96 (2005)
DOI:10.1007/s00253-005-1898-1
Reference
  Authors
Serizawa M, Sekiguchi J
  Title
The Bacillus subtilis YdfHI two-component system regulates the transcription of ydfJ, a member of the RND superfamily.
  Journal
Microbiology 151:1769-78 (2005)
DOI:10.1099/mic.0.27619-0
Reference
  Authors
Ohki R, Giyanto, Tateno K, Masuyama W, Moriya S, Kobayashi K, Ogasawara N
  Title
The BceRS two-component regulatory system induces expression of the bacitracin transporter, BceAB, in Bacillus subtilis.
  Journal
Mol Microbiol 49:1135-44 (2003)
DOI:10.1046/j.1365-2958.2003.03653.x
Reference
  Authors
Ogura M, Tsukahara K, Hayashi K, Tanaka T
  Title
The Bacillus subtilis NatK-NatR two-component system regulates expression of the natAB operon encoding an ABC transporter for sodium ion extrusion.
  Journal
Microbiology 153:667-75 (2007)
DOI:10.1099/mic.0.2006/003673-0
Reference
  Authors
Yamamoto H, Murata M, Sekiguchi J
  Title
The CitST two-component system regulates the expression of the Mg-citrate transporter in Bacillus subtilis.
  Journal
Mol Microbiol 37:898-912 (2000)
DOI:10.1046/j.1365-2958.2000.02055.x
Reference
  Authors
Satomura T, Shimura D, Asai K, Sadaie Y, Hirooka K, Fujita Y
  Title
Enhancement of glutamine utilization in Bacillus subtilis through the GlnK-GlnL two-component regulatory system.
  Journal
J Bacteriol 187:4813-21 (2005)
DOI:10.1128/JB.187.14.4813-4821.2005
Reference
  Authors
Doan T, Servant P, Tojo S, Yamaguchi H, Lerondel G, Yoshida K, Fujita Y, Aymerich S
  Title
The Bacillus subtilis ywkA gene encodes a malic enzyme and its transcription is activated by the YufL/YufM two-component system in response to malate.
  Journal
Microbiology 149:2331-43 (2003)
DOI:10.1099/mic.0.26256-0
Reference
  Authors
Tanaka K, Kobayashi K, Ogasawara N
  Title
The Bacillus subtilis YufLM two-component system regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium.
  Journal
Microbiology 149:2317-29 (2003)
DOI:10.1099/mic.0.26257-0
Reference
  Authors
Asai K, Baik SH, Kasahara Y, Moriya S, Ogasawara N
  Title
Regulation of the transport system for C4-dicarboxylic acids in Bacillus subtilis.
  Journal
Microbiology 146 ( Pt 2):263-71 (2000)
DOI:10.1099/00221287-146-2-263
Reference
PMID:8455557
  Authors
Hamblin MJ, Shaw JG, Kelly DJ
  Title
Sequence analysis and interposon mutagenesis of a sensor-kinase (DctS) and response-regulator (DctR) controlling synthesis of the high-affinity C4-dicarboxylate transport system in Rhodobacter capsulatus.
  Journal
Mol Gen Genet 237:215-24 (1993)
DOI:10.1007/BF00282803
Reference
PMID:9287004
  Authors
Forward JA, Behrendt MC, Wyborn NR, Cross R, Kelly DJ
  Title
TRAP transporters: a new family of periplasmic solute transport systems encoded by the dctPQM genes of Rhodobacter capsulatus and by homologs in diverse gram-negative bacteria.
  Journal
J Bacteriol 179:5482-93 (1997)
DOI:10.1128/JB.179.17.5482-5493.1997
Reference
  Authors
Martin B, Quentin Y, Fichant G, Claverys JP
  Title
Independent evolution of competence regulatory cascades in streptococci?
  Journal
Trends Microbiol 14:339-45 (2006)
DOI:10.1016/j.tim.2006.06.007
Reference
  Authors
Hensel M, Hinsley AP, Nikolaus T, Sawers G, Berks BC
  Title
The genetic basis of tetrathionate respiration in Salmonella typhimurium.
  Journal
Mol Microbiol 32:275-87 (1999)
DOI:10.1046/j.1365-2958.1999.01345.x
Reference
  Authors
Guvener ZT, Harwood CS
  Title
Subcellular location characteristics of the Pseudomonas aeruginosa GGDEF protein, WspR, indicate that it produces cyclic-di-GMP in response to growth on surfaces.
  Journal
Mol Microbiol 66:1459-73 (2007)
DOI:10.1111/j.1365-2958.2007.06008.x
Reference
  Authors
Bantinaki E, Kassen R, Knight CG, Robinson Z, Spiers AJ, Rainey PB
  Title
Adaptive divergence in experimental populations of Pseudomonas fluorescens. III. Mutational origins of wrinkly spreader diversity.
  Journal
Genetics 176:441-53 (2007)
DOI:10.1534/genetics.106.069906
Reference
  Authors
Jiang M, Shao W, Perego M, Hoch JA
  Title
Multiple histidine kinases regulate entry into stationary phase and sporulation in Bacillus subtilis.
  Journal
Mol Microbiol 38:535-42 (2000)
DOI:10.1046/j.1365-2958.2000.02148.x
Reference
  Authors
Jenal U
  Title
The role of proteolysis in the Caulobacter crescentus cell cycle and development.
  Journal
Res Microbiol 160:687-95 (2009)
DOI:10.1016/j.resmic.2009.09.006
Reference
  Authors
Jenal U, Galperin MY
  Title
Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics.
  Journal
Curr Opin Microbiol 12:152-60 (2009)
DOI:10.1016/j.mib.2009.01.010
Reference
  Authors
Drepper T, Wiethaus J, Giaourakis D, Gross S, Schubert B, Vogt M, Wiencek Y, McEwan AG, Masepohl B
  Title
Cross-talk towards the response regulator NtrC controlling nitrogen metabolism in Rhodobacter capsulatus.
  Journal
FEMS Microbiol Lett 258:250-6 (2006)
DOI:10.1111/j.1574-6968.2006.00228.x
Reference
PMID:1661370
  Authors
Pawlowski K, Klosse U, de Bruijn FJ
  Title
Characterization of a novel Azorhizobium caulinodans ORS571 two-component regulatory system, NtrY/NtrX, involved in nitrogen fixation and metabolism.
  Journal
Mol Gen Genet 231:124-38 (1991)
DOI:10.1007/BF00293830
Reference
  Authors
Chatterjee S, Almeida RP, Lindow S
  Title
Living in two worlds: the plant and insect lifestyles of Xylella fastidiosa.
  Journal
Annu Rev Phytopathol 46:243-71 (2008)
DOI:10.1146/annurev.phyto.45.062806.094342
Reference
  Authors
Dow M
  Title
Diversification of the function of cell-to-cell signaling in regulation of virulence within plant pathogenic xanthomonads.
  Journal
Sci Signal 1:pe23 (2008)
DOI:10.1126/stke.121pe23
Reference
  Authors
Colnaghi Simionato AV, da Silva DS, Lambais MR, Carrilho E
  Title
Characterization of a putative Xylella fastidiosa diffusible signal factor by HRGC-EI-MS.
  Journal
J Mass Spectrom 42:1375-81 (2007)
DOI:10.1002/jms.1325
Reference
  Authors
Miller LD, Russell MH, Alexandre G
  Title
Diversity in bacterial chemotactic responses and niche adaptation.
  Journal
Adv Appl Microbiol 66:53-75 (2009)
DOI:10.1016/S0065-2164(08)00803-4
Reference
PMID:8760916
  Authors
Eder S, Shi L, Jensen K, Yamane K, Hulett FM
  Title
A Bacillus subtilis secreted phosphodiesterase/alkaline phosphatase is the product of a Pho regulon gene, phoD.
  Journal
Microbiology 142 ( Pt 8):2041-7 (1996)
DOI:10.1099/13500872-142-8-2041
Related
pathway
ppsy00190  Oxidative phosphorylation
ppsy00550  Peptidoglycan biosynthesis
ppsy00910  Nitrogen metabolism
ppsy02030  Bacterial chemotaxis
ppsy02040  Flagellar assembly
ppsy03070  Bacterial secretion system
KO pathway
ko02020   
LinkDB

DBGET integrated database retrieval system