KEGG   PATHWAY: ppyr00983
Entry
ppyr00983                   Pathway                                
Name
Drug metabolism - other enzymes - Photinus pyralis (common eastern firefly)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
ppyr00983  Drug metabolism - other enzymes
ppyr00983

Organism
Photinus pyralis (common eastern firefly) [GN:ppyr]
Gene
116165861  inosine-5'-monophosphate dehydrogenase isoform X1 [KO:K00088] [EC:1.1.1.205]
116177771  GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
116177444  xanthine dehydrogenase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
116165573  xanthine dehydrogenase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
116176375  LOW QUALITY PROTEIN: xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
116176415  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
116176470  xanthine dehydrogenase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
116176584  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
116181756  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
116177945  venom carboxylesterase-6-like [KO:K01044] [EC:3.1.1.1]
116171512  venom carboxylesterase-6-like [KO:K01044] [EC:3.1.1.1]
116167168  venom carboxylesterase-6-like isoform X1 [KO:K01044] [EC:3.1.1.1]
116168251  UDP-glucuronosyltransferase 1-5-like [KO:K00699] [EC:2.4.1.17]
116168252  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
116169126  UDP-glucuronosyltransferase 2B19-like [KO:K00699] [EC:2.4.1.17]
116169468  UDP-glucuronosyltransferase 1-9-like isoform X1 [KO:K00699] [EC:2.4.1.17]
116169469  UDP-glucuronosyltransferase 1-7C-like [KO:K00699] [EC:2.4.1.17]
116159877  UDP-glucuronosyltransferase 2B19-like [KO:K00699] [EC:2.4.1.17]
116169888  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
116179952  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
116180065  UDP-glucuronosyltransferase 2B16-like [KO:K00699] [EC:2.4.1.17]
116160027  UDP-glucuronosyltransferase 2B19-like isoform X1 [KO:K00699] [EC:2.4.1.17]
116160091  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
116160151  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
116160160  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
116160546  UDP-glucuronosyltransferase 2B17-like isoform X1 [KO:K00699] [EC:2.4.1.17]
116160558  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
116170684  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
116180302  UDP-glucuronosyltransferase 2B1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
116180609  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
116161274  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
116180810  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
116180931  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
116180962  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
116181004  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
116181045  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
116181047  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
116181111  UDP-glucuronosyltransferase 3A2-like [KO:K00699] [EC:2.4.1.17]
116181155  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
116181211  UDP-glucuronosyltransferase 1-3-like isoform X1 [KO:K00699] [EC:2.4.1.17]
116181215  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
116181246  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
116181248  UDP-glucuronosyltransferase 2B2-like [KO:K00699] [EC:2.4.1.17]
116181270  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
116161729  UDP-glucuronosyltransferase 2B20-like [KO:K00699] [EC:2.4.1.17]
116161730  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
116161818  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
116161886  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
116161950  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
116161952  UDP-glucuronosyltransferase 2A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
116161953  UDP-glucuronosyltransferase 1-3-like [KO:K00699] [EC:2.4.1.17]
116161954  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
116181343  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
116181350  UDP-glucuronosyltransferase 2B1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
116181443  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
116181489  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
116181742  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
116162392  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
116182652  UDP-glucuronosyltransferase 2B19-like isoform X1 [KO:K00699] [EC:2.4.1.17]
116173883  UDP-glucuronosyltransferase 2B10-like [KO:K00699] [EC:2.4.1.17]
116174532  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
116174692  UDP-glucuronosyltransferase 2B20-like [KO:K00699] [EC:2.4.1.17]
116174748  UDP-glucuronosyltransferase 2B20-like [KO:K00699] [EC:2.4.1.17]
116175826  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
116176217  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
116177671  beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
116179521  LOW QUALITY PROTEIN: uncharacterized protein LOC116179521 [KO:K01489] [EC:3.5.4.5]
116178541  dihydropyrimidine dehydrogenase [NADP(+)] isoform X1 [KO:K00207] [EC:1.3.1.2]
116174196  dihydropyrimidine dehydrogenase [NADP(+)]-like [KO:K00207] [EC:1.3.1.2]
116165276  dihydropyrimidinase isoform X1 [KO:K01464] [EC:3.5.2.2]
116162523  beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
116166951  uridine phosphorylase 1 [KO:K00757] [EC:2.4.2.3]
116161251  uridine-cytidine kinase isoform X1 [KO:K00876] [EC:2.7.1.48]
116175056  uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
116179026  uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
116165247  UMP-CMP kinase-like [KO:K13800] [EC:2.7.4.14]
116169634  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
116172349  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
116178896  nucleoside diphosphate kinase 6-like isoform X1 [KO:K00940] [EC:2.7.4.6]
116159667  nucleoside diphosphate kinase 7-like [KO:K00940] [EC:2.7.4.6]
116181703  nucleoside diphosphate kinase 7-like [KO:K00940] [EC:2.7.4.6]
116173253  nucleoside diphosphate kinase-like [KO:K00940] [EC:2.7.4.6]
116173254  nucleoside diphosphate kinase-like [KO:K00940] [EC:2.7.4.6]
116173308  nucleoside diphosphate kinase-like [KO:K00940] [EC:2.7.4.6]
116158953  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial [KO:K01520] [EC:3.6.1.23]
116167738  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116177271  glutathione S-transferase D1-like [KO:K00799] [EC:2.5.1.18]
116168599  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116158692  pyrimidodiazepine synthase-like [KO:K00799] [EC:2.5.1.18]
116158715  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116158987  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116178787  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116179223  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
116159428  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116159657  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
116161781  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116181425  glutathione S-transferase D1-like [KO:K00799] [EC:2.5.1.18]
116181532  glutathione S-transferase D1-like [KO:K00799] [EC:2.5.1.18]
116163152  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116172953  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116172954  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116173220  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116173484  glutathione S-transferase 4-like [KO:K00799] [EC:2.5.1.18]
116173907  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116173965  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
116173999  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
116174000  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116174001  glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
116174039  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116174040  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
116174466  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116174517  uncharacterized protein LOC116174517 [KO:K00799] [EC:2.5.1.18]
116174643  pyrimidodiazepine synthase-like [KO:K00799] [EC:2.5.1.18]
116174966  glutathione S-transferase D5-like [KO:K00799] [EC:2.5.1.18]
116175139  glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
116166776  glutathione S-transferase 1-1 [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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