KEGG   PATHWAY: prap00983
Entry
prap00983                   Pathway                                
Name
Drug metabolism - other enzymes - Pieris rapae (cabbage white)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
prap00983  Drug metabolism - other enzymes
prap00983

Organism
Pieris rapae (cabbage white) [GN:prap]
Gene
111001220  inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
110997703  GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
110992974  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
110992986  probable aldehyde oxidase gad-3 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
110994009  xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
110994024  xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
111002738  indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
110991669  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
110991684  xanthine dehydrogenase 1-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
110991702  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
110991712  indole-3-acetaldehyde oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123689272  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
110994189  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
110993567  UDP-glucosyltransferase 2 isoform X1 [KO:K00699] [EC:2.4.1.17]
110993632  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
110993087  UDP-glucosyltransferase 2 [KO:K00699] [EC:2.4.1.17]
110995626  UDP-glucosyltransferase 2 [KO:K00699] [EC:2.4.1.17]
111001681  UDP-glucosyltransferase 2 [KO:K00699] [EC:2.4.1.17]
111001697  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
111003288  UDP-glucosyltransferase 2 [KO:K00699] [EC:2.4.1.17]
111003289  UDP-glucosyltransferase 2 [KO:K00699] [EC:2.4.1.17]
111003292  UDP-glycosyltransferase UGT5 [KO:K00699] [EC:2.4.1.17]
111003420  UDP-glycosyltransferase UGT5 [KO:K00699] [EC:2.4.1.17]
111003436  UDP-glycosyltransferase UGT5 isoform X2 [KO:K00699] [EC:2.4.1.17]
111003437  UDP-glycosyltransferase UGT5 [KO:K00699] [EC:2.4.1.17]
110995915  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
110995916  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
110995909  UDP-glucosyltransferase 2 [KO:K00699] [EC:2.4.1.17]
110999362  UDP-glycosyltransferase UGT5 [KO:K00699] [EC:2.4.1.17]
110999365  UDP-glucosyltransferase 2 [KO:K00699] [EC:2.4.1.17]
110999367  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
111003419  UDP-glycosyltransferase UGT5 isoform X1 [KO:K00699] [EC:2.4.1.17]
110999237  UDP-glycosyltransferase UGT5 [KO:K00699] [EC:2.4.1.17]
110999238  UDP-glycosyltransferase UGT5 isoform X2 [KO:K00699] [EC:2.4.1.17]
110999246  UDP-glucosyltransferase 2 [KO:K00699] [EC:2.4.1.17]
111000255  UDP-glucosyltransferase 2 [KO:K00699] [EC:2.4.1.17]
111000256  UDP-glucosyltransferase 2 isoform X1 [KO:K00699] [EC:2.4.1.17]
123689113  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
110995072  UDP-glucosyltransferase 2 [KO:K00699] [EC:2.4.1.17]
123689737  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
111000249  uncharacterized protein LOC111000249 [KO:K00699] [EC:2.4.1.17]
123689950  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
123689984  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
111000292  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
111003628  cytidine deaminase [KO:K01489] [EC:3.5.4.5]
111001391  dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
110995540  dihydropyrimidinase isoform X1 [KO:K01464] [EC:3.5.2.2]
111004000  beta-ureidopropionase-like [KO:K01431] [EC:3.5.1.6]
111003207  beta-ureidopropionase-like [KO:K01431] [EC:3.5.1.6]
111003206  beta-ureidopropionase-like [KO:K01431] [EC:3.5.1.6]
110998462  uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
111001932  uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
111002089  uridine-cytidine kinase isoform X1 [KO:K00876] [EC:2.7.1.48]
111003477  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
110993562  uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
110996305  UMP-CMP kinase-like [KO:K13800] [EC:2.7.4.14]
110994951  ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
110999125  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
111001181  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
110994348  nucleoside diphosphate kinase 7-like [KO:K00940] [EC:2.7.4.6]
110994364  nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
110992443  deoxyuridine 5'-triphosphate nucleotidohydrolase [KO:K01520] [EC:3.6.1.23]
111001050  glutathione S-transferase 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
111001053  glutathione S-transferase E14-like isoform X1 [KO:K00799] [EC:2.5.1.18]
111002680  glutathione S-transferase 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
111002681  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
110998893  glutathione S-transferase 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
111001088  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111001295  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
111001296  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
110993324  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111000241  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
111000244  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
111001578  glutathione S-transferase 1-1 [KO:K00799] [EC:2.5.1.18]
123689686  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
123690204  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
LinkDB

DBGET integrated database retrieval system