KEGG   PATHWAY: ptk00260
Entry
ptk00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas tructae
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ptk00260  Glycine, serine and threonine metabolism
ptk00260

Module
ptk_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ptk00260]
ptk_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ptk00260]
ptk_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:ptk00260]
ptk_M00555  Betaine biosynthesis, choline => betaine [PATH:ptk00260]
ptk_M00621  Glycine cleavage system [PATH:ptk00260]
ptk_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:ptk00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas tructae [GN:ptk]
Gene
EXN22_08930  aspartate kinase [KO:K00928] [EC:2.7.2.4]
EXN22_19615  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
EXN22_07075  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
EXN22_01925  homoserine kinase [KO:K02204] [EC:2.7.1.39]
EXN22_18440  thrH; bifunctional phosphoserine phosphatase/homoserine phosphotransferase ThrH [KO:K02203] [EC:3.1.3.3 2.7.1.39]
EXN22_07080  threonine synthase [KO:K01733] [EC:4.2.3.1]
EXN22_25655  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
EXN22_25650  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EXN22_05140  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EXN22_05530  2-hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]
EXN22_23135  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
EXN22_14400  glycerate kinase [KO:K00865] [EC:2.7.1.165]
EXN22_09525  glycerate kinase [KO:K11529] [EC:2.7.1.165]
EXN22_03210  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
EXN22_02555  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
EXN22_20440  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
EXN22_03920  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
EXN22_03565  flavin monoamine oxidase family protein [KO:K00274] [EC:1.4.3.4]
EXN22_00365  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
EXN22_06615  gcvP; glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
EXN22_00375  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
EXN22_06605  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
EXN22_01345  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EXN22_09010  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EXN22_09990  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EXN22_00370  gcvH; glycine cleavage system protein GcvH [KO:K02437]
EXN22_06620  gcvH; glycine cleavage system protein GcvH [KO:K02437]
EXN22_14000  phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
EXN22_14005  hypothetical protein [KO:K17103] [EC:2.7.8.8]
EXN22_23645  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
EXN22_03160  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
EXN22_03165  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
EXN22_22145  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
EXN22_25700  gbcA; glycine-betaine demethylase subunit GbcA [KO:K00479] [EC:1.14.13.251]
EXN22_25690  gbcB; glycine-betaine demethylase subunit GbcB [KO:K21832] [EC:1.14.13.251]
EXN22_25720  dgcA; dimethylglycine demethylation protein DgcA [KO:K21833] [EC:1.5.7.3]
EXN22_25715  dgcB; dimethylglycine demethylation protein DgcB [KO:K21834]
EXN22_25710  electron transfer flavoprotein subunit alpha/FixB family protein [KO:K25960]
EXN22_25705  electron transfer flavoprotein subunit beta [KO:K25961]
EXN22_25635  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
EXN22_25645  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
EXN22_25630  soxG; sarcosine oxidase subunit gamma family protein [KO:K00305] [EC:1.5.3.24 1.5.3.1]
EXN22_25640  sarcosine oxidase subunit delta family protein [KO:K00304] [EC:1.5.3.24 1.5.3.1]
EXN22_08140  pyridoxal-phosphate dependent enzyme [KO:K01697] [EC:4.2.1.22]
EXN22_11070  PLP-dependent transferase [KO:K01758] [EC:4.4.1.1]
EXN22_25785  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
EXN22_06610  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
EXN22_14945  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
EXN22_02585  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
EXN22_08495  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
EXN22_13415  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
EXN22_14240  pyridoxal-phosphate dependent enzyme [KO:K17989] [EC:4.3.1.17 4.3.1.19]
EXN22_15615  D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
EXN22_01725  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
EXN22_01730  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
EXN22_09850  aspartate aminotransferase family protein [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ptk00010  Glycolysis / Gluconeogenesis
ptk00020  Citrate cycle (TCA cycle)
ptk00230  Purine metabolism
ptk00250  Alanine, aspartate and glutamate metabolism
ptk00270  Cysteine and methionine metabolism
ptk00290  Valine, leucine and isoleucine biosynthesis
ptk00300  Lysine biosynthesis
ptk00330  Arginine and proline metabolism
ptk00460  Cyanoamino acid metabolism
ptk00470  D-Amino acid metabolism
ptk00564  Glycerophospholipid metabolism
ptk00620  Pyruvate metabolism
ptk00630  Glyoxylate and dicarboxylate metabolism
ptk00640  Propanoate metabolism
ptk00680  Methane metabolism
ptk00860  Porphyrin metabolism
ptk00920  Sulfur metabolism
KO pathway
ko00260   
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