KEGG   PATHWAY: pvm00480
Entry
pvm00480                    Pathway                                
Name
Glutathione metabolism - Penaeus vannamei (Pacific white shrimp)
Class
Metabolism; Metabolism of other amino acids
Pathway map
pvm00480  Glutathione metabolism
pvm00480

Module
pvm_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:pvm00480]
Other DBs
GO: 0006749
Organism
Penaeus vannamei (Pacific white shrimp) [GN:pvm]
Gene
113815914  LOW QUALITY PROTEIN: glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
113815919  glutathione hydrolase 1 proenzyme-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
113828393  gamma-glutamylcyclotransferase-like [KO:K00682] [EC:4.3.2.9]
113825095  putative glutathione-specific gamma-glutamylcyclotransferase 2 [KO:K07232] [EC:4.3.2.7]
113815347  putative glutathione-specific gamma-glutamylcyclotransferase 2 [KO:K07232] [EC:4.3.2.7]
113827743  putative glutathione-specific gamma-glutamylcyclotransferase 2 isoform X1 [KO:K07232] [EC:4.3.2.7]
113803630  5-oxoprolinase-like [KO:K01469] [EC:3.5.2.9]
113802161  glutamate--cysteine ligase catalytic subunit-like [KO:K11204] [EC:6.3.2.2]
113800464  glutamate--cysteine ligase regulatory subunit-like [KO:K11205]
113822762  glutathione synthetase-like [KO:K21456] [EC:6.3.2.3]
113809087  glutathione synthetase-like [KO:K21456] [EC:6.3.2.3]
113811350  cytosol aminopeptidase-like isoform X1 [KO:K11142] [EC:3.4.11.1 3.4.11.5]
113808035  cytosol aminopeptidase-like [KO:K11142] [EC:3.4.11.1 3.4.11.5]
113820218  putative aminopeptidase W07G4.4 [KO:K01255] [EC:3.4.11.1]
113804788  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
113804789  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
113804819  LOW QUALITY PROTEIN: aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
113804821  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
113804822  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
113804828  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
113815275  LOW QUALITY PROTEIN: aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
113815278  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
113819573  LOW QUALITY PROTEIN: aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
113811397  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
113811418  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
113811419  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
113823539  aminopeptidase N-like isoform X1 [KO:K11140] [EC:3.4.11.2]
113815289  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
113815290  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
113815291  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
113815295  LOW QUALITY PROTEIN: puromycin-sensitive aminopeptidase-like protein [KO:K11140] [EC:3.4.11.2]
113815297  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
113817626  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
113817632  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
113805053  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
113817770  LOW QUALITY PROTEIN: glutathione S-transferase class-mu 26 kDa isozyme 47-like [KO:K00799] [EC:2.5.1.18]
113821223  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
113821236  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
113823540  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
113828161  glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
113829262  glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
113801166  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
113812983  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
113822637  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
113817634  glutathione S-transferase T2-like [KO:K00799] [EC:2.5.1.18]
113813522  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
113817660  glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
113827876  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
113800662  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
113812551  LOW QUALITY PROTEIN: glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
113812552  LOW QUALITY PROTEIN: glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
113826926  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
113829050  microsomal glutathione S-transferase 3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
113829084  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
113807146  glutathione S-transferase kappa 1-like isoform X1 [KO:K13299] [EC:2.5.1.18]
113809598  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
113817477  glutathione S-transferase-like isoform X1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
113811885  isocitrate dehydrogenase [NADP] cytoplasmic-like [KO:K00031] [EC:1.1.1.42]
113830388  isocitrate dehydrogenase [NADP], mitochondrial-like [KO:K00031] [EC:1.1.1.42]
113803123  6-phosphogluconate dehydrogenase, decarboxylating-like isoform X1 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
113826602  glucose-6-phosphate 1-dehydrogenase-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
113820074  thioredoxin domain-containing protein 12-like [KO:K05360] [EC:1.8.4.2]
113800343  glutathione peroxidase-like isoform X1 [KO:K05361] [EC:1.11.1.12]
113805292  glutathione peroxidase 7-like [KO:K00432] [EC:1.11.1.9]
113816684  glutathione peroxidase-like [KO:K00432] [EC:1.11.1.9]
113826359  glutathione peroxidase-like [KO:K00432] [EC:1.11.1.9]
113819893  glutathione peroxidase 2-like [KO:K00432] [EC:1.11.1.9]
113819894  glutathione peroxidase 2-like [KO:K00432] [EC:1.11.1.9]
113823673  peroxiredoxin-6-like [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
113823675  LOW QUALITY PROTEIN: peroxiredoxin-6-like [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
113808340  pyrimidodiazepine synthase-like [KO:K00310] [EC:1.5.4.1]
113818669  pyrimidodiazepine synthase-like [KO:K00310] [EC:1.5.4.1]
113817114  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
113819876  spermidine synthase-like [KO:K00797] [EC:2.5.1.16]
113821773  LOW QUALITY PROTEIN: spermine synthase-like [KO:K00802] [EC:2.5.1.22]
113825151  spermine synthase-like [KO:K00802] [EC:2.5.1.22]
113824641  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
pvm00220  Arginine biosynthesis
pvm00250  Alanine, aspartate and glutamate metabolism
pvm00270  Cysteine and methionine metabolism
pvm00430  Taurine and hypotaurine metabolism
KO pathway
ko00480   
LinkDB

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