KEGG   PATHWAY: pvm04146
Entry
pvm04146                    Pathway                                
Name
Peroxisome - Penaeus vannamei (Pacific white shrimp)
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
pvm04146  Peroxisome
pvm04146

Other DBs
GO: 0005777
Organism
Penaeus vannamei (Pacific white shrimp) [GN:pvm]
Gene
113812630  peroxisomal membrane protein PEX16-like [KO:K13335]
113806503  peroxisomal biogenesis factor 3-like [KO:K13336]
113811238  peroxisomal biogenesis factor 19-like [KO:K13337]
113820857  ATP-binding cassette sub-family D member 3-like [KO:K05677] [EC:7.6.2.4]
113812875  peroxisome biogenesis factor 1-like [KO:K13338]
113811796  peroxisome assembly factor 2-like [KO:K13339]
113802552  peroxisomal targeting signal 1 receptor-like [KO:K13342]
113828244  peroxisomal membrane protein PEX14-like [KO:K13343]
113810158  probable peroxisomal membrane protein PEX13 [KO:K13344]
113827276  peroxisome assembly protein 12-like [KO:K13345]
113828432  peroxisome biogenesis factor 10-like [KO:K13346]
113816598  peroxisome biogenesis factor 2-like [KO:K06664]
113829617  peroxisome biogenesis factor 2-like [KO:K06664]
113800347  peroxisomal membrane protein 2-like [KO:K13347]
113823542  mpv17-like protein 2 [KO:K13348]
113804238  protein sym1-like [KO:K13348]
113802994  mpv17-like protein 2 [KO:K13348]
113806352  mpv17-like protein [KO:K13348]
113826906  PXMP2/4 family protein 4-like [KO:K13348]
113817392  protein Mpv17-like [KO:K13348]
113808562  mpv17-like protein [KO:K13349]
113807166  mpv17-like protein [KO:K13349]
113805022  peroxisomal membrane protein 11A-like [KO:K13352]
113829844  peroxisomal membrane protein PMP34-like [KO:K13354]
113829823  LOW QUALITY PROTEIN: 2-hydroxyacyl-CoA lyase 1-like [KO:K12261] [EC:4.1.2.63]
113809547  2-hydroxyacyl-CoA lyase 1-like [KO:K12261] [EC:4.1.2.63]
113811729  phytanoyl-CoA dioxygenase, peroxisomal-like [KO:K00477] [EC:1.14.11.18]
113805335  uncharacterized protein LOC113805335 [KO:K00477] [EC:1.14.11.18]
113829127  peroxisomal acyl-coenzyme A oxidase 1-like [KO:K00232] [EC:1.3.3.6]
113818451  acyl-coenzyme A oxidase 3, peroxisomal-like isoform X1 [KO:K00232] [EC:1.3.3.6]
113818504  peroxisomal acyl-coenzyme A oxidase 1-like [KO:K00232] [EC:1.3.3.6]
113830051  probable peroxisomal acyl-coenzyme A oxidase 1 [KO:K00232] [EC:1.3.3.6]
113818099  peroxisomal multifunctional enzyme type 2-like isoform X1 [KO:K12405] [EC:1.1.1.- 4.2.1.107 4.2.1.119]
113823286  LOW QUALITY PROTEIN: non-specific lipid-transfer protein-like [KO:K08764] [EC:2.3.1.176]
113813493  delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial-like [KO:K12663] [EC:5.3.3.21]
113825168  ATP-binding cassette sub-family D member 2-like [KO:K05676] [EC:7.6.2.4]
113802455  ATP-binding cassette sub-family D member 4-like [KO:K05678] [EC:7.6.2.8]
113827572  long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]
113810702  long chain acyl-CoA synthetase 9, chloroplastic-like [KO:K01897] [EC:6.2.1.3]
113810703  long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]
113809380  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
113809137  peroxisomal trans-2-enoyl-CoA reductase-like [KO:K07753] [EC:1.3.1.38]
113828491  enoyl-CoA delta isomerase 2, mitochondrial-like [KO:K13239] [EC:5.3.3.8]
113807680  enoyl-CoA delta isomerase 2, mitochondrial-like [KO:K13239] [EC:5.3.3.8]
113807546  LOW QUALITY PROTEIN: enoyl-CoA delta isomerase 2, mitochondrial-like [KO:K13239] [EC:5.3.3.8]
113805937  enoyl-CoA delta isomerase 2, mitochondrial-like isoform X1 [KO:K13239] [EC:5.3.3.8]
113820057  nucleoside diphosphate-linked moiety X motif 13-like [KO:K03426] [EC:3.6.1.22]
113808465  carnitine O-acetyltransferase-like [KO:K00624] [EC:2.3.1.7]
113818487  carnitine O-acetyltransferase-like isoform X1 [KO:K00624] [EC:2.3.1.7]
113813496  peroxisomal carnitine O-octanoyltransferase-like [KO:K05940] [EC:2.3.1.137]
113823999  malonyl-CoA decarboxylase, mitochondrial-like [KO:K01578] [EC:4.1.1.9]
113821045  dihydroxyacetone phosphate acyltransferase-like [KO:K00649] [EC:2.3.1.42]
113806121  LOW QUALITY PROTEIN: alkyldihydroxyacetonephosphate synthase, peroxisomal-like [KO:K00803] [EC:2.5.1.26]
113808882  putative fatty acyl-CoA reductase CG5065 [KO:K13356] [EC:1.2.1.84]
113817072  LOW QUALITY PROTEIN: mevalonate kinase-like [KO:K00869] [EC:2.7.1.36]
113818834  serine--pyruvate aminotransferase-like isoform X1 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
113821591  D-amino-acid oxidase-like [KO:K00273] [EC:1.4.3.3]
113827158  D-aspartate oxidase-like [KO:K00272] [EC:1.4.3.1]
113799947  D-aspartate oxidase-like [KO:K00272] [EC:1.4.3.1]
113811885  isocitrate dehydrogenase [NADP] cytoplasmic-like [KO:K00031] [EC:1.1.1.42]
113830388  isocitrate dehydrogenase [NADP], mitochondrial-like [KO:K00031] [EC:1.1.1.42]
113805206  spermine oxidase-like [KO:K00308] [EC:1.5.3.13]
113827514  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
113821931  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
113824411  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
113801983  hydroxymethylglutaryl-CoA lyase, mitochondrial-like [KO:K01640] [EC:4.1.3.4]
113802152  hydroxymethylglutaryl-CoA lyase, mitochondrial-like [KO:K01640] [EC:4.1.3.4]
113824636  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
113829896  catalase-like isoform X1 [KO:K03781] [EC:1.11.1.6]
113807833  peroxiredoxin-5, mitochondrial-like [KO:K11187] [EC:1.11.1.24]
113807384  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
113809633  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
113817999  LOW QUALITY PROTEIN: superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
113815071  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
113830370  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
113823550  superoxide dismutase [Mn], mitochondrial-like isoform X1 [KO:K04564] [EC:1.15.1.1]
113828312  superoxide dismutase [Mn], mitochondrial-like [KO:K04564] [EC:1.15.1.1]
113818229  LOW QUALITY PROTEIN: superoxide dismutase [Mn], mitochondrial-like [KO:K04564] [EC:1.15.1.1]
113814492  peroxiredoxin 1-like [KO:K13279] [EC:1.11.1.24]
113807146  glutathione S-transferase kappa 1-like isoform X1 [KO:K13299] [EC:2.5.1.18]
113807596  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
113818250  probable aldehyde oxidase 4 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
113820698  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
113803334  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
113821249  LOW QUALITY PROTEIN: indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
113822117  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
113816325  indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
113816330  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
113824316  dehydrogenase/reductase SDR family member 4-like [KO:K11147] [EC:1.1.-.-]
Reference
PMID:17055078
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
PMID:17055079
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
PMID:17010456
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
PMID:16631601
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
pvm00071  Fatty acid degradation
pvm00230  Purine metabolism
pvm00564  Glycerophospholipid metabolism
pvm00565  Ether lipid metabolism
pvm00830  Retinol metabolism
pvm00900  Terpenoid backbone biosynthesis
KO pathway
ko04146   
LinkDB

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