KEGG   PATHWAY: pxu00983
Entry
pxu00983                    Pathway                                
Name
Drug metabolism - other enzymes - Papilio xuthus (Asian swallowtail)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
pxu00983  Drug metabolism - other enzymes
pxu00983

Organism
Papilio xuthus (Asian swallowtail) [GN:pxu]
Gene
106123538  inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
106126711  GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
106116114  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
106125300  xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
106126443  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
106113607  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
106113736  indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
106113818  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
106113820  indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
106113821  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
106113900  aldehyde oxidase 1-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
106113906  indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
106127705  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
106121595  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
106121736  UDP-glucuronosyltransferase 2B2-like [KO:K00699] [EC:2.4.1.17]
106121737  UDP-glucuronosyltransferase 2B2-like [KO:K00699] [EC:2.4.1.17]
106121739  UDP-glucuronosyltransferase 2B18-like [KO:K00699] [EC:2.4.1.17]
106121842  UDP-glucuronosyltransferase-like [KO:K00699] [EC:2.4.1.17]
106122850  UDP-glucuronosyltransferase 3A1-like [KO:K00699] [EC:2.4.1.17]
106115586  UDP-glucuronosyltransferase [KO:K00699] [EC:2.4.1.17]
106116505  UDP-glucuronosyltransferase 3A1-like [KO:K00699] [EC:2.4.1.17]
106116615  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
106116705  UDP-glucuronosyltransferase 1-7C-like [KO:K00699] [EC:2.4.1.17]
106116706  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
106116707  UDP-glucuronosyltransferase 2B9-like [KO:K00699] [EC:2.4.1.17]
106116774  UDP-glucuronosyltransferase 2B10-like [KO:K00699] [EC:2.4.1.17]
106116877  UDP-glucuronosyltransferase 2B2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
106118498  UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
106118502  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
106118538  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
106118561  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
106118565  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
106118570  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
106118572  UDP-glucuronosyltransferase 2B19-like [KO:K00699] [EC:2.4.1.17]
106118665  UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
106118666  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
106118681  UDP-glucuronosyltransferase 2B15-like isoform X1 [KO:K00699] [EC:2.4.1.17]
106118703  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
106118711  UDP-glucuronosyltransferase 2B19-like isoform X1 [KO:K00699] [EC:2.4.1.17]
106125966  UDP-glucuronosyltransferase 1-7C-like [KO:K00699] [EC:2.4.1.17]
106126500  UDP-glucuronosyltransferase 1-8-like isoform X1 [KO:K00699] [EC:2.4.1.17]
106119999  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
106120259  UDP-glucuronosyltransferase 1-9-like [KO:K00699] [EC:2.4.1.17]
106128218  UDP-glucuronosyltransferase 2B30-like [KO:K00699] [EC:2.4.1.17]
106128260  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
106115856  beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
106126683  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
106119011  dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
106123171  dihydropyrimidinase isoform X1 [KO:K01464] [EC:3.5.2.2]
106119411  beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
106115275  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
106127576  uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
106117440  probable uridine-cytidine kinase isoform X1 [KO:K00876] [EC:2.7.1.48]
106121492  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
106118931  uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
106114060  UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
106125382  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
106124475  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
106124063  nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
106117154  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
106124685  nucleoside diphosphate kinase 7-like [KO:K00940] [EC:2.7.4.6]
106125622  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
106116863  deoxyuridine 5'-triphosphate nucleotidohydrolase [KO:K01520] [EC:3.6.1.23]
106114126  glutathione S-transferase 1-1 [KO:K00799] [EC:2.5.1.18]
106114338  glutathione S-transferase 1, isoform D-like [KO:K00799] [EC:2.5.1.18]
106114388  glutathione S-transferase 1, isoform D-like [KO:K00799] [EC:2.5.1.18]
106122586  glutathione S-transferase D7-like isoform X1 [KO:K00799] [EC:2.5.1.18]
106115209  uncharacterized protein LOC106115209 [KO:K00799] [EC:2.5.1.18]
106115229  glutathione S-transferase 4-like [KO:K00799] [EC:2.5.1.18]
106115234  glutathione S-transferase 1, isoform C-like [KO:K00799] [EC:2.5.1.18]
106115289  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
106115311  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
106116829  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
106116830  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
106117349  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
106117350  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
106117351  uncharacterized protein LOC106117351 [KO:K00799] [EC:2.5.1.18]
106119401  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
106119671  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
106127230  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
106113489  glutathione S-transferase 1-1 [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
LinkDB

DBGET integrated database retrieval system