KEGG   PATHWAY: raw00260
Entry
raw00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Rhizobium anhuiense bv. trifolii
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
raw00260  Glycine, serine and threonine metabolism
raw00260

Module
raw_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:raw00260]
raw_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:raw00260]
raw_M00555  Betaine biosynthesis, choline => betaine [PATH:raw00260]
raw_M00621  Glycine cleavage system [PATH:raw00260]
raw_M00919  Ectoine degradation, ectoine => aspartate [PATH:raw00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Rhizobium anhuiense bv. trifolii [GN:raw]
Gene
NE851_30700  aspartate kinase [KO:K00928] [EC:2.7.2.4]
NE851_09585  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
NE851_19850  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
NE851_15045  homoserine kinase [KO:K02204] [EC:2.7.1.39]
NE851_15155  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
NE851_29600  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
NE851_17885  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
NE851_07080  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
NE851_34245  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
NE851_10940  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
NE851_19345  glycerate kinase [KO:K11529] [EC:2.7.1.165]
NE851_08200  glycerate kinase [KO:K11529] [EC:2.7.1.165]
NE851_14850  glycerate kinase [KO:K11529] [EC:2.7.1.165]
NE851_22270  histidine phosphatase family protein [KO:K01834] [EC:5.4.2.11]
NE851_10890  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
NE851_28985  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
NE851_01350  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
NE851_28990  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
NE851_25700  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
NE851_26510  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
NE851_26505  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
NE851_31195  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
NE851_10285  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
NE851_03285  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
NE851_05315  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
NE851_24650  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
NE851_21780  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
NE851_21770  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
NE851_05330  DUF1989 domain-containing protein [KO:K00605] [EC:2.1.2.10]
NE851_05395  aminomethyltransferase family protein [KO:K00605] [EC:2.1.2.10]
NE851_20190  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
NE851_31445  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
NE851_00515  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
NE851_21775  gcvH; glycine cleavage system protein GcvH [KO:K02437]
NE851_17385  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
NE851_07565  CDP-alcohol phosphatidyltransferase family protein [KO:K17103] [EC:2.7.8.8]
NE851_15915  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
NE851_18905  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
NE851_33545  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
NE851_15920  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
NE851_34030  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
NE851_14745  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
NE851_34025  FAD-binding oxidoreductase [KO:K21832] [EC:1.14.13.251]
NE851_29875  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
NE851_29885  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
NE851_29870  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
NE851_29880  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
NE851_21620  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
NE851_19105  ilvA; threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
NE851_29440  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
NE851_32090  eutB; hydroxyectoine utilization dehydratase EutB [KO:K01754] [EC:4.3.1.19]
NE851_09545  pyridoxal-phosphate dependent enzyme [KO:K17989] [EC:4.3.1.17 4.3.1.19]
NE851_06655  alanine racemase [KO:K01753] [EC:4.3.1.18]
NE851_09840  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
NE851_09835  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
NE851_07060  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
NE851_07100  ectoine synthase [KO:K06720] [EC:4.2.1.108]
NE851_16590  ectoine synthase [KO:K06720] [EC:4.2.1.108]
NE851_32100  doeA; ectoine hydrolase DoeA [KO:K15783] [EC:3.5.4.44]
NE851_32105  doeB; N(2)-acetyl-L-2,4-diaminobutanoate deacetylase DoeB [KO:K15784] [EC:3.5.1.125]
NE851_07130  aspartate aminotransferase family protein [KO:K15785] [EC:2.6.1.76]
NE851_32045  aspartate aminotransferase family protein [KO:K15785] [EC:2.6.1.76]
NE851_32050  NAD-dependent succinate-semialdehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
raw00010  Glycolysis / Gluconeogenesis
raw00020  Citrate cycle (TCA cycle)
raw00230  Purine metabolism
raw00250  Alanine, aspartate and glutamate metabolism
raw00270  Cysteine and methionine metabolism
raw00290  Valine, leucine and isoleucine biosynthesis
raw00300  Lysine biosynthesis
raw00330  Arginine and proline metabolism
raw00460  Cyanoamino acid metabolism
raw00470  D-Amino acid metabolism
raw00564  Glycerophospholipid metabolism
raw00600  Sphingolipid metabolism
raw00620  Pyruvate metabolism
raw00630  Glyoxylate and dicarboxylate metabolism
raw00640  Propanoate metabolism
raw00680  Methane metabolism
raw00860  Porphyrin metabolism
raw00920  Sulfur metabolism
KO pathway
ko00260   
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