Entry Name Graft-versus-host disease - Rhinopithecus bieti (black snub-nosed monkey)
Description Graft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells. GVHD pathophysiology can be summerized in a three-step process. Step 1 involves the development of an inflammatory milieu resulting from damage in the host tissues induced by the preparative chemotherapy or radiotherapy regimen. Damaged tissues secrete inflammatory cytokines, including interleukin 1 (IL-1), and tumor necrosis factor (TNF-alpha ). During step 2, antigen-presenting cells (APCs) trigger the activation of donor-derived T cells, which induce further T-cell expansion, induce cytotoxic T lymphocytes (CTL) and natural killer (NK) cells responses and prime additional mononuclear phagocytes to produce TNF-alpha and IL-1. Also, nitric oxide (NO) is produced by activated macrophages, and it may contribute to the tissue damage seen during step 3. During step 3, the effector phase, activated CTL and NK cells mediate cytotoxicity against target host cells through Fas-Fas ligand interactions and perforin-granzyme B.
Class Human Diseases; Immune diseaseBRITE hierarchy
Pathway map Ortholog table Organism Rhinopithecus bieti (black snub-nosed monkey) [GN:
rbb ]
Gene 108540290 HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752 ]
108540291 HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752 ]
108540294 HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752 ]
108512973 HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752 ]
108512974 HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752 ]
108512982 HLA class II histocompatibility antigen, DO beta chain [KO:K06752 ]
108512983 HLA class II histocompatibility antigen, DQ beta 1 chain [KO:K06752 ]
108512984 HLA class II histocompatibility antigen, DQ alpha 1 chain [KO:K06752 ]
108512985 HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752 ]
108519881 mamu class II histocompatibility antigen, DR alpha chain [KO:K06752 ]
108519884 HLA class II histocompatibility antigen, DRB1-13 beta chain isoform X1 [KO:K06752 ]
108519885 HLA class II histocompatibility antigen, DR beta 5 chain [KO:K06752 ]
108541888 CD80; T-lymphocyte activation antigen CD80 isoform X1 [KO:K05412 ]
108541474 CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413 ]
108537220 CD28; T-cell-specific surface glycoprotein CD28 isoform X1 [KO:K06470 ]
108543093 class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751 ]
108543097 class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751 ]
108525667 HLA class I histocompatibility antigen, B-38 alpha chain isoform X1 [KO:K06751 ]
108528429 mamu class I histocompatibility antigen, alpha chain F [KO:K06751 ]
108528432 saoe class I histocompatibility antigen, C alpha chain-like isoform X1 [KO:K06751 ]
108528436 HLA class I histocompatibility antigen, A-11 alpha chain isoform X1 [KO:K06751 ]
108522562 popy class I histocompatibility antigen, alpha chain E isoform X1 [KO:K06751 ]
108526259 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
108526609 FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390 ]
108522013 killer cell immunoglobulin-like receptor 3DS1 isoform X1 [KO:K07980 ]
108518726 killer cell immunoglobulin-like receptor 3DL3 isoform X1 [KO:K07980 ]
108521201 putative killer cell immunoglobulin-like receptor-like protein KIR3DX1 [KO:K07980 ]
108521206 putative killer cell immunoglobulin-like receptor-like protein KIR3DX1 [KO:K07980 ]
Compound Reference Authors Ferrara JL, Reddy P.
Title Pathophysiology of graft-versus-host disease.
Journal Reference Authors Reddy P.
Title Pathophysiology of acute graft-versus-host disease.
Journal Reference Authors Sun Y, Tawara I, Toubai T, Reddy P.
Title Pathophysiology of acute graft-versus-host disease: recent advances.
Journal Reference Authors Jaksch M, Mattsson J.
Title The pathophysiology of acute graft-versus-host disease.
Journal Reference Authors Vogelsang GB, Lee L, Bensen-Kennedy DM.
Title Pathogenesis and treatment of graft-versus-host disease after bone marrow transplant.
Journal Reference Authors Reddy P, Ferrara JL.
Title Immunobiology of acute graft-versus-host disease.
Journal Reference Authors Blazar BR, Murphy WJ.
Title Bone marrow transplantation and approaches to avoid graft-versus-host disease (GVHD).
Journal Reference Authors Couriel D, Caldera H, Champlin R, Komanduri K.
Title Acute graft-versus-host disease: pathophysiology, clinical manifestations, and management.
Journal Reference Authors Jacobsohn DA, Vogelsang GB.
Title Acute graft versus host disease.
Journal Related rbb04060 Cytokine-cytokine receptor interaction
rbb04612 Antigen processing and presentation
rbb04620 Toll-like receptor signaling pathway
rbb04650 Natural killer cell mediated cytotoxicity
rbb04660 T cell receptor signaling pathway
KO pathway LinkDB All DBs
