Entry
Name
Cytokine-cytokine receptor interaction - Rhinopithecus bieti (black snub-nosed monkey)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
rbb04060 Cytokine-cytokine receptor interaction
Organism
Rhinopithecus bieti (black snub-nosed monkey) [GN:
rbb ]
Gene
108512287 IL17RE; LOW QUALITY PROTEIN: interleukin-17 receptor E [KO:K05168 ]
108512423 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
108512733 IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069 ]
108514105 TNFSF11; tumor necrosis factor ligand superfamily member 11 isoform X1 [KO:K05473 ]
108514316 TNFSF13; tumor necrosis factor ligand superfamily member 13 isoform X1 [KO:K05475 ]
108514784 IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598 ]
108515975 OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
108516504 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
108517919 TNFRSF9; tumor necrosis factor receptor superfamily member 9 isoform X1 [KO:K05146 ]
108517955 TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160 ]
108518354 CCR10; LOW QUALITY PROTEIN: C-C chemokine receptor type 10 [KO:K04185 ]
108518477 CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738 ]
108518617 CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421 ]
108520527 EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162 ]
108520941 IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737 ]
108521977 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
108522971 IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136 ]
108523340 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A isoform X1 [KO:K05149 ]
108523999 EDA2R; tumor necrosis factor receptor superfamily member 27 isoform X1 [KO:K05163 ]
108524091 IL1R1; LOW QUALITY PROTEIN: interleukin-1 receptor type 1 [KO:K04386 ]
108524097 IL18R1; LOW QUALITY PROTEIN: interleukin-18 receptor 1 [KO:K05173 ]
108524104 IL18RAP; LOW QUALITY PROTEIN: interleukin-18 receptor accessory protein [KO:K05174 ]
108524105 IL1RL2; LOW QUALITY PROTEIN: interleukin-1 receptor-like 2 [KO:K05172 ]
108526259 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
108526260 TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
108526262 TNFSF4; tumor necrosis factor ligand superfamily member 4 isoform X1 [KO:K05469 ]
108526386 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
108526609 FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390 ]
108527051 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
108529905 IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
108529907 IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068 ]
108530480 IL1RAP; LOW QUALITY PROTEIN: interleukin-1 receptor accessory protein [KO:K04723 ]
108531178 TNFRSF19; tumor necrosis factor receptor superfamily member 19 isoform X1 [KO:K05155 ]
108531426 IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137 ]
108531438 AMH; LOW QUALITY PROTEIN: muellerian-inhibiting factor [KO:K04665 ]
108532108 IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070 ]
108532136 TNFSF8; tumor necrosis factor ligand superfamily member 8 isoform X1 [KO:K05471 ]
108532137 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
108532763 GDF7; LOW QUALITY PROTEIN: growth/differentiation factor 7 [KO:K20013 ]
108533001 BMP2; LOW QUALITY PROTEIN: bone morphogenetic protein 2 [KO:K21283 ]
108533323 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
108534594 TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
108534608 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
108534711 CCR7; LOW QUALITY PROTEIN: C-C chemokine receptor type 7 [KO:K04182 ]
108535316 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
108535573 IL5RA; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067 ]
108536022 TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
108536211 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
108536390 IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134 ]
108536491 LTBR; tumor necrosis factor receptor superfamily member 3 [KO:K03159 ]
108536511 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
108536853 IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135 ]
108537272 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
108537955 TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722 ]
108538617 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B isoform X1 [KO:K05150 ]
108539384 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141 ]
108539396 TNFRSF8; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 8 [KO:K05145 ]
108540415 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
108540777 TNFRSF10C; tumor necrosis factor receptor superfamily member 10C [KO:K22701 ]
108540791 TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722 ]
108541253 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
108541801 IL36RN; interleukin-36 receptor antagonist protein isoform X1 [KO:K05483 ]
108541817 IL1RN; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
108542167 IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056 ]
108542186 CNTFR; LOW QUALITY PROTEIN: ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
108543554 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151 ]
108543762 RELT; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156 ]
108544213 TNFRSF18; tumor necrosis factor receptor superfamily member 18 isoform X1 [KO:K05154 ]
108544216 TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway