KEGG   PATHWAY: rbq00260
Entry
rbq00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Rhizobium binae
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
rbq00260  Glycine, serine and threonine metabolism
rbq00260

Module
rbq_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:rbq00260]
rbq_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:rbq00260]
rbq_M00555  Betaine biosynthesis, choline => betaine [PATH:rbq00260]
rbq_M00621  Glycine cleavage system [PATH:rbq00260]
rbq_M00919  Ectoine degradation, ectoine => aspartate [PATH:rbq00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Rhizobium binae [GN:rbq]
Gene
J2J99_19920  aspartate kinase [KO:K00928] [EC:2.7.2.4]
J2J99_29790  uridylate kinase [KO:K00928] [EC:2.7.2.4]
J2J99_21840  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
J2J99_29795  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
J2J99_09735  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
J2J99_05065  homoserine kinase [KO:K02204] [EC:2.7.1.39]
J2J99_05150  threonine synthase [KO:K01733] [EC:4.2.3.1]
J2J99_18910  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
J2J99_07760  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
J2J99_01110  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
J2J99_23835  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
J2J99_09335  glycerate kinase [KO:K11529] [EC:2.7.1.165]
J2J99_01060  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
J2J99_12270  phosphoglycerate mutase family protein [KO:K01834] [EC:5.4.2.11]
J2J99_18305  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
J2J99_25340  hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
J2J99_18310  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
J2J99_14710  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
J2J99_15490  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
J2J99_15485  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
J2J99_20390  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
J2J99_26195  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
J2J99_28695  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
J2J99_11715  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
J2J99_11705  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
J2J99_10140  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
J2J99_20590  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
J2J99_24695  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
J2J99_11710  gcvH; glycine cleavage system protein GcvH [KO:K02437]
J2J99_07310  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
J2J99_05975  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
J2J99_05980  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
J2J99_04770  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
J2J99_30985  2Fe-2S iron-sulfur cluster binding domain-containing protein [KO:K21832] [EC:1.14.13.251]
J2J99_19100  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
J2J99_19110  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
J2J99_19095  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
J2J99_19105  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
J2J99_11570  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
J2J99_09125  ilvA; threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
J2J99_18750  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
J2J99_22080  eutB; hydroxyectoine utilization dehydratase EutB [KO:K01754] [EC:4.3.1.19]
J2J99_21815  pyridoxal-phosphate dependent enzyme [KO:K17989] [EC:4.3.1.17 4.3.1.19]
J2J99_00115  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
J2J99_00110  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
J2J99_29880  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
J2J99_04890  ectoine synthase [KO:K06720] [EC:4.2.1.108]
J2J99_30815  M24 family metallopeptidase [KO:K15783] [EC:3.5.4.44]
J2J99_30825  M24 family metallopeptidase [KO:K15783] [EC:3.5.4.44]
J2J99_30865  aminopeptidase P family protein [KO:K15783] [EC:3.5.4.44]
J2J99_31785  M24 family metallopeptidase [KO:K15783] [EC:3.5.4.44]
J2J99_31800  aminopeptidase P family protein [KO:K15783] [EC:3.5.4.44]
J2J99_22090  doeA; ectoine hydrolase DoeA [KO:K15783] [EC:3.5.4.44]
J2J99_22095  doeB; N(2)-acetyl-L-2,4-diaminobutanoate deacetylase DoeB [KO:K15784] [EC:3.5.1.125]
J2J99_31695  aspartate aminotransferase family protein [KO:K15785] [EC:2.6.1.76]
J2J99_22035  aspartate aminotransferase family protein [KO:K15785] [EC:2.6.1.76]
J2J99_22040  NAD-dependent succinate-semialdehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
rbq00010  Glycolysis / Gluconeogenesis
rbq00020  Citrate cycle (TCA cycle)
rbq00230  Purine metabolism
rbq00250  Alanine, aspartate and glutamate metabolism
rbq00270  Cysteine and methionine metabolism
rbq00290  Valine, leucine and isoleucine biosynthesis
rbq00300  Lysine biosynthesis
rbq00330  Arginine and proline metabolism
rbq00460  Cyanoamino acid metabolism
rbq00470  D-Amino acid metabolism
rbq00564  Glycerophospholipid metabolism
rbq00600  Sphingolipid metabolism
rbq00620  Pyruvate metabolism
rbq00630  Glyoxylate and dicarboxylate metabolism
rbq00640  Propanoate metabolism
rbq00680  Methane metabolism
rbq00860  Porphyrin metabolism
rbq00920  Sulfur metabolism
KO pathway
ko00260   
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