KEGG   PATHWAY: rep00260
Entry
rep00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Rhizobium etli bv. phaseoli IE4803
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
rep00260  Glycine, serine and threonine metabolism
rep00260

Module
rep_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:rep00260]
rep_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:rep00260]
rep_M00555  Betaine biosynthesis, choline => betaine [PATH:rep00260]
rep_M00621  Glycine cleavage system [PATH:rep00260]
rep_M00919  Ectoine degradation, ectoine => aspartate [PATH:rep00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Rhizobium etli bv. phaseoli IE4803 [GN:rep]
Gene
IE4803_CH04129  lysC; aspartate kinase [KO:K00928] [EC:2.7.2.4]
IE4803_CH04485  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
IE4803_CH03890  hom-2; homoserine dehydrogenase 2 [KO:K00003] [EC:1.1.1.3]
IE4803_CH01912  hom-1; homoserine dehydrogenase 1 [KO:K00003] [EC:1.1.1.3]
IE4803_CH00970  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
IE4803_CH03899  protein kinase-like domain-containing protein [KO:K02204] [EC:2.7.1.39]
IE4803_CH00987  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
IE4803_PC00580  ltaE-2; low-specificity threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]
IE4803_CH03942  ltaE-1; low-specificity threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
IE4803_CH01512  glyA-1; serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
IE4803_CH02021  glyA-2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
IE4803_CH03647  sgaA; serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
IE4803_PC00351  ghrA-2; bifunctional glyoxylate/hydroxypyruvate reductase A 2 [KO:K12972] [EC:1.1.1.79 1.1.1.81]
IE4803_CH00201  ghrA-1; bifunctional glyoxylate/hydroxypyruvate reductase A 1 [KO:K12972] [EC:1.1.1.79 1.1.1.81]
IE4803_CH01824  ttuD; hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
IE4803_CH02395  phosphoglycerate mutase protein [KO:K01834] [EC:5.4.2.11]
IE4803_CH00189  gpmA-1; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
IE4803_PB00221  gpmA-2; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
IE4803_CH03804  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
IE4803_CH02254  D-3-phosphoglycerate dehydrogenase protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
IE4803_CH03805  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
IE4803_CH02931  phosphoserine phosphatase SerB-like protein [KO:K01079] [EC:3.1.3.3]
IE4803_CH03180  bifunctional 8-amino-7-oxononanoate synthase/2-amino-3-ketobutyrate coenzyme A ligase protein [KO:K00639] [EC:2.3.1.29]
IE4803_CH03179  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
IE4803_CH04227  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
IE4803_PA00364  amine oxidase protein [KO:K00274] [EC:1.4.3.4]
IE4803_CH02298  gcvP; glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
IE4803_CH02296  gcvT; aminomethyltransferase (glycine-cleavage system T protein) [KO:K00605] [EC:2.1.2.10]
IE4803_CH04265  dihydrolipoamide dehydrogenase protein [KO:K00382] [EC:1.8.1.4]
IE4803_CH03691  lpdA-2; dihydrolipoamide dehydrogenase 2 [KO:K00382] [EC:1.8.1.4]
IE4803_CH01995  lpdA-1; dihydrolipoamide dehydrogenase 1 [KO:K00382] [EC:1.8.1.4]
IE4803_PD00073  lpdV; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
IE4803_CH02297  gcvH; glycine-cleavage system protein H [KO:K02437]
IE4803_CH01424  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
IE4803_CH01162  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
IE4803_CH01164  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
IE4803_PC00471  betaine aldehyde dehydrogenase protein [KO:K00130] [EC:1.2.1.8]
IE4803_CH00914  dioxygenase protein [KO:K00479] [EC:1.14.13.251]
IE4803_PC00380  ring-hydroxylating dioxygenase protein [KO:K00479] [EC:1.14.13.251]
IE4803_PC00381  ferredoxin reductase-type FAD/NAD-binding protein [KO:K21832] [EC:1.14.13.251]
IE4803_CH03980  soxA-1; sarcosine oxidase alpha subunit SoxA 1 [KO:K00302] [EC:1.5.3.24 1.5.3.1]
IE4803_CH03982  soxB-1; sarcosine oxidase beta subunit SoxB 1 [KO:K00303] [EC:1.5.3.24 1.5.3.1]
IE4803_CH03979  soxG-1; sarcosine oxidase gamma subunit SoxG 1 [KO:K00305] [EC:1.5.3.24 1.5.3.1]
IE4803_CH03981  soxD-1; sarcosine oxidase delta subunit SoxD 1 [KO:K00304] [EC:1.5.3.24 1.5.3.1]
IE4803_CH02232  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
IE4803_PC00587  tdcB; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
IE4803_CH01790  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
IE4803_PC00201  eutB; ectoine utilization protein EutB [KO:K01754] [EC:4.3.1.19]
IE4803_CH03909  pyridoxal phosphate-dependent serine/threonine dehydratase protein [KO:K01754] [EC:4.3.1.19]
IE4803_CH04480  pyridoxal phosphate-dependent serine/threonine dehydratase protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
IE4803_CH02015  dsdA; D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
IE4803_CH00021  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
IE4803_CH00020  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
IE4803_PC00199  eutD; ectoine utilization protein EutD [KO:K15783] [EC:3.5.4.44]
IE4803_PC00198  eutE; ectoine utilization protein EutE [KO:K15784] [EC:3.5.1.125]
IE4803_CH03639  pyridoxal phosphate-dependent aminotransferase protein [KO:K15785] [EC:2.6.1.76]
IE4803_PC00210  aminotransferase class 3 protein [KO:K15785] [EC:2.6.1.76]
IE4803_PC00209  succinate-semialdehyde dehydrogenase (NADP+) protein [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
rep00010  Glycolysis / Gluconeogenesis
rep00020  Citrate cycle (TCA cycle)
rep00230  Purine metabolism
rep00250  Alanine, aspartate and glutamate metabolism
rep00270  Cysteine and methionine metabolism
rep00290  Valine, leucine and isoleucine biosynthesis
rep00300  Lysine biosynthesis
rep00330  Arginine and proline metabolism
rep00460  Cyanoamino acid metabolism
rep00470  D-Amino acid metabolism
rep00564  Glycerophospholipid metabolism
rep00600  Sphingolipid metabolism
rep00620  Pyruvate metabolism
rep00630  Glyoxylate and dicarboxylate metabolism
rep00640  Propanoate metabolism
rep00680  Methane metabolism
rep00860  Porphyrin metabolism
rep00920  Sulfur metabolism
KO pathway
ko00260   
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